Low-Dose Naltrexone for Fibromyalgia and ME/CFS
17 August 2022
Low-dose naltrexone therapy helps to relieve pain and fatigue associated with fibromyalgia and chronic fatigue syndrome. Small studies have shown that individuals taking LDN to treat fibromyalgia showed as much as a 30% decline in symptoms compared to those given a fake treatment. Results tended to be best in those who had an inflammatory response, which is when the immune system responds to injury or illness. The drug was also well tolerated, with minimal side effects.
LDN is not FDA-approved for fibromyalgia but is sometimes prescribed for off-label use. Research suggests that individuals with chronic fatigue syndrome may have neuroinflammation, which is an inflammatory response in the brain or spinal cord. Because LDN may have an impact on inflammation in the nervous system, it's understandable why this may be a helpful treatment for some.
Research shows some promise for low-dose naltrexone in treating these other conditions:
Relapsing major depressive disorder