Can Low Dose Naltrexone (LDN) help Burning Mouth Syndrome?

LDN Specialist Pharmacist Michelle Moser
Pharmacist Michelle Moser

Can Low Dose Naltrexone (LDN) help Burning Mouth Syndrome?

One person asks: “Do you have any experience with Burning Mouth Syndrome?” 
I'm so glad somebody asked this question. There is a paper that was written on Low Dose Naltrexone and Burning Mouth Syndrome specifically. And this person was using other medications as well. She also had chronic pain. She was on an antidepressant. She was on Lyrica. She was on other nerve medications as well. And she started Low Dose Naltrexone and she slowly increased her dose. 

She got up to 4.5. And in this case study, she noted at 4.5 that about 50-60%, maybe even a little bit higher, no, it's around 50-60% of her symptoms were resolved at that dose. But for whatever reason, she went back down to three milligram and she found even a better resolution of her symptoms. 

So I found that very interesting and very helpful. So, when I speak to dentists about some of the issues that we can help with, especially with autoimmune, whether it's like in Sclerosis or, or Burning Mouth Syndrome, sometimes Burning Mouth is a symptom of long COVID or long Vax or has to do with other chronic illness. 

And so that is been very helpful. And yes, try it. It usually has to be an oral capsule. So we don't necessarily use like a topical rinse. Sometimes we you can still use a steroid topical rinse, but we would still use an oral Low Dose Naltrexone.