The LDN Books

We would like to thank all the authors for their time and support with The LDN Books, as well as the staff at Chelsea Green Publishing.  Generously, all royalties will be given to the LDN Research Trust. 

Low Dose Naltrexone (LDN) holds the potential to help millions of people suffering from various autoimmune diseases and cancers, and even those with autism, chronic fatigue, and depression find relief. Administered off-label in small daily doses (0.5 to 4.5 mg), this generic drug is extremely affordable and presents few known side effects. So why has it languished in relative medical obscurity?

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Listen to the authors who wrote chapters in volume 2.

A comprehensive examination of Low Dose Naltrexone—a little-known drug with big potential

A drug that is simultaneously affordable, devoid of severe side effects, and applicable to a wide range of diseases is not often found in the modern pharmaceutical landscape. But as medical professionals and researchers alike continue to discover, Low Dose Naltrexone (LDN) boasts this remarkable combination.

LDN, originally prescribed in higher doses as a treatment for opioid addiction, works by blocking opioid receptors, thereby stimulating the production of endorphins, mitigating the inflammatory process, and stabilizing the immune response. Prescribed off-label and administered in small daily doses, this generic drug has proven useful in treating many different ailments.

Expanding on the information presented in The LDN Book, Volume 1—which showcased LDN’s efficacy in treating conditions such as lupus, thyroiditis, autism spectrum disorder, and chronic fatigue—Volume 2 highlights the latest clinical trials, case studies, and research on LDN. More than a dozen medical professionals explain how they are using LDN to help patients suffering from chronic pain, Parkinson’s disease, dermatologic conditions, traumatic brain injury, Lyme disease, and more.

The LDN Book, Volume 2 is both a resource for practitioners, pharmacists and patients and a renewed call for further research on the healing potential of this generic drug.

Details of the LDN Book Volume 2 Launch and Tour and purchase discounted books 

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Praise for The LDN Book Volume 2

Dr. Angus Dalgleish, professor of oncology, St. George’s, University of London; principal, Institute for Cancer Vaccines and Immunotherapy (ICVI)

“Even if you think you know about the benefits of LDN for certain conditions through practical experience or otherwise, this book will expand your understanding and amazement. It is a remarkable finding that a drug designed for a specific condition can be applied to so many other systems at lower and lower doses. Interestingly, this has shown us that many other drugs may also have unexpected benefits at lower-than-intended doses. There are many layers of complexity that remain to be uncovered!”

Dr. Andrew McCall, director, Clinic 158

“Over the years, a wealth of clinical trials and studies on LDN have given us better information about how and why LDN actually works. Through this research, we have uncovered many new uses of LDN in medical treatment. Reviewing The LDN Book, Volume 2 and seeing how other experts prescribe LDN in their clinics has been a great treat for me. My clinic, Clinic 158, has been prescribing LDN for 12 years. We have thousands of very happy patients who have found success with the medication for a myriad of ailments, and we are still learning new information.”

Dr. Nasha Winters, ND, FABNO, author of The Metabolic Approach to Cancer

"Since the first volume of The LDN Book was released, I have had the distinct privilege of learning from and collaborating with the best clinicians and researchers in the field of integrative medicine. Through these collaborations, we continue to build upon the already vast applications of this low-dose but high-power medication. I am thrilled to see so many trusted colleagues, who have also become friends, contribute to this important body of work. Thank you, again, Linda Elsegood, for bringing together a tribe of like-minded people who continue to find solutions to challenging medical issues with this simple and inexpensive intervention.”

Dr. Izabella Wentz, Pharm.D., FASCP, New York Times bestselling author of Hashimoto’s Protocol

“As a pharmacist, I often wish for a ‘miracle’ drug that would be safe, effective, and inexpensive and could help the masses take back their health. While no drug is right for everyone, I have seen LDN transform the lives of countless people with autoimmunity. For some, LDN has truly been a miracle drug. I highly recommend both volumes of The LDN Book as valuable resources for patients and clinicians alike to explore the best practices for using LDN.”

Jill C. Carnahan, MD, ABIHM, ABoIM, IFMCP

“A fantastic resource. All the latest research on low dose naltrexone and its various uses in clinical practice is compiled in this easy-to-use volume—The LDN Book, Volume 2. I will definitely be keeping this book in my office for reference.”

Sahar Swidan, Pharm.D., R.Ph., ABAAHP, FAARFM, FACA, president and CEO, Pharmacy Solutions

“Since inflammation is a major contributor to almost all chronic disorders, LDN therapy bridges nearly every medical specialty. In The LDN Book, Volume 2, the authors provide an excellent overview of LDN’s mechanism of action, review the vast evidence base supporting clinical applications, and, most importantly, report actual cases in which LDN was instrumental in the successful treatment of patients. This book is a must-have for every clinician, and LDN should be considered in the treatment of the many disorders outlined therein.”

Praise for The LDN Book Volume 1

Dr. Chris Steele, MBE, general practitioner; medical presenter on ITV’s This Morning

“I first came across LDN several years ago when a medical colleague said I should look into its positive effects in patients with MS, Crohn’s disease, and other autoimmune disorders. I was so impressed with what I read that I helped submit a petition to the UK government to ask for funding for further research into this inexpensive drug. But, as with so many petitions, no progress was made. I hope The LDN Book—which presents up-to-date findings that again confirm the efficacy of this safe, cheap, generic drug in helping to control many chronic, disabling conditions—is read by those in the Department of Health and by all doctors caring for patients with autoimmune disease. In the UK, LDN has been stranded in limbo; maybe now the time has come for it to be accepted as a recognized therapy that could, at least, be tried on those suffering such long-term diseases of the immune system.”

New Review The LDN Book - Jacqueline Young - Jackie is the Patron of the LDN Research Trust

“Low Dose Naltrexone (LDN) was discovered by my husband and partner, Dr. Bernard Bihari. Incredibly informative and superbly written by various members of the medical profession sharing their experiences using this extraordinary drug, The LDN Book honors his legacy in helping patients suffering from autoimmune and other diseases to regain their health and their lives.”

The LDN Book review by Dr Thomas Cowan

“As a practicing physician who has used LDN as a cornerstone therapy for over fifteen years, I can say without equivocation that LDN is the most important and successful medicine I have ever used. I often joke that if not for LDN I couldn’t pay my mortgage; I’ve had so many new patients referred to me by someone whose life has improved dramatically through the use of LDN. And despite my knowledge and experience with LDN, I’ve learned a great deal from The LDN Book—aspects of its basic science I hadn’t known, new uses, and how its uses can inform us about the causes of various diseases. This is a wonderful book for any patient with an autoimmune disease, cancer, depression, or a host of other conditions and is a must-read for any physician whose goal is to help their patients.”

— Dr. Thomas Cowan, author of The Fourfold Path to Healing and co-author of The Nourishing Traditions Book of Baby & Child Care

Introduction to The LDN Book Volume 1  - Click Here


Many people have written books on LDN that are informative and inspirational for those researching LDN. Please see: Other LDN Books