Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Warning - Fake Medications
Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease) (Abstract)
Low-dose Naltrexone Therapy for Psoriasis (Abstract)
Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone (Abstract)
Opioid-immune interactions in autism... (Abstract)
Low-dose naltrexone and opioid consumption: a drug utilization cohort study... (Abstract)
Dose Escalation of Naltrexone to Reduce Stress Responses Associated With Opioid Antagonist Induction... (Abstract)
Clinical utility of the cold pressor test: evaluation of pain patients... (Abstract)
Co-Administration of Low-Dose Naltrexone and Bupropion Reduces Alcohol Drinking... (Abstract)
Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone... (Abstract)
Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome (Abstract)
Relationship of human herpes virus 6 and multiple sclerosis: A systematic review and meta-analysis (Abstract)
Ultra-low dose naloxone restores the antinocicepitve effect of morphine in... (Abstract)
Combination therapy: A New Tool for the Management of Obesity (Abstract)
Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills? (Abstract)
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone(Abstract)
Low‐dose naltrexone in Hailey–Hailey disease: the importance of dosing (Abstract)
Naltrexone in autistic children: an acute open dose range tolerance trial (Abstract)
Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity (Abstract)
Functional modulation on macrophage by low dose naltrexone (LDN) (Abstract)
Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders (Abstract)
Intermittent blockade of OGFr and treatment of autoimmune disorders (Abstract)
Combination therapy for obesity (Abstract)
Low dose naltrexone in therapy resistant IBD, a case series (Abstract)
Low Dose Naltrexone in Endometrial Intraepithelial Neoplasia (Abstract)
The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction ... (Abstract)
A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers-Danlos Syndrome (Abstract)
Low-dose naltrexone use for the management of post-acute sequelae of COVID-19 (Abstract)
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review (Abstract)
Successful induction of ovulation in normogonadotrophic clomiphene resistant anovulatory women... (Abstract)
The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris... (Abstract)
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF)... (Abstract)
Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization (Abstract)
Low-Dose Naltrexone: A New Therapy Option for Complex Regional Pain Syndrome Type I Patients (Abstract)
Anxiolytics, adrenergic agents, and naltrexone (Abstract)
Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Condition... (Abstract)
Low dose naltrexone in multiple sclerosis: Effects on medication use... (Abstract)
Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment (Abstract)
Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells (Abstract)
Geo-Statistical Analysis of Possible Spirochetal Involvement in Multiple Sclerosis (Abstract)
Off-label pharmacological treatment for neuropathic pain... (Abstract)
Treatment of dissociative symptoms with opioid antagonists: a systematic review (Abstract)
Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA (Abstract)
Naltrexone and other potential new pharmacological treatments of autism (Abstract)
Transition of Patients With Opioid Use Disorder From Buprenorphine to Extended-Release Naltrexone... (Abstract)
Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders (Abstract)
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis (Abstract)
Opioid growth factor and low dose naltrexone impair central nervous system infiltration... (Abstract)
Long-term effects of naltrexone on self-injurious behavior (Abstract)
Treatment of psoriasis vulgaris using low-dose naltrexone (Abstract)
Low-dose naltrexone: a novel treatment for Hailey-Hailey disease (Abstract)
Immunological changes in IBD patients responding to low-dose naltrexone treatment (Abstract)
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome... (Abstract)
The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice (Abstract)
Long COVID: major findings, mechanisms and recommendations (Abstract)
Low-Dose Naltrexone Improves post-COVID-19 Condition Symptoms
Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia (Abstract)
The Uses of Low-Dose Naltrexone in Clinical Practice (Abstract)
Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders (Abstract)
The long-term survival of a patient with pancreatic cancer with metastases to the liver... (Abstract)
A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence (Abstract)
Effects of low-dose naltrexone on feed intake, growth, endocrine and immune... (Abstract)
Early outcomes following low dose naltrexone enhancement of opioid detoxification (Abstract)
The Long Term Suppression of Experimental Autoimmune Encephalomyelitis... (Abstract)
Naltrexone modulates growth in infant rats )Abstract)
Impact of Low Dose Naltrexone (LDN) on antiretroviral therapy (ART) treated HIV+ adults... (Abstract)
A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A (Abstract) (LDN, low dose naltrexone)
Topical Therapeutic Options in Corneal Neuropathic Pain (Abstract)
Diagnosis and Management of a Hypersensitivity Reaction to Titanium-Containing Surgical Clips... (Abstract)
Current pharmacotherapeutic properties of low-dose naltrexone therapy in humans and possible therapeutic and prophylactic indications in cats and dogs
Ameliorative response to detoxification, psychotherapy, and medical management in patients maintained on opioids for pain (Abstract)
Naltrexone and Dysphoria: Fact or Myth? (Abstract)
Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone (Abstract)
Naltrexone plasma levels, clinical response and effect on weight in autistic children (Abstract)
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone (Abstract)
Treatment of clinically isolated syndrome with Low Dose Naltrexone (Abstract)
Low-Dose Naltrexone in Diseases' Treatment: Global Review (Abstract)
Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion (Abstract)
Opioid antagonist-induced regulation of organ development (Abstract)
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer ... (Abstract)
Low-dose naltrexone (LDN)—review of therapeutic utilization (Abstract)
Response to: Invasive Treatments for Low Back Disorders and the ACOEM Practice Guidelines (Abstract)
An Update on the Uses of Naltrexone in Clinical Practice (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits... (Abstract)
Low dose naltrexone in the treatment of fibromyalgia (Abstract)
Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis (Abstract)
Placebo-controlled acute dosage naltrexone study in young autistic children (Abstract)
Variable Response to Naltrexone in Patients With Hailey-Hailey Disease (Abstract)
Duration of opioid receptor blockade determines biotherapeutic response (Abstract)
Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis (Abstract)
Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution ... (Abstract)
Opioid antagonist modulation of murine neuroblastoma... (Abstract)
What Do Primary Care Providers and Nurses Need to Know About Managing Chronic Pain? (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia: protocol for... (Abstract)
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic... (Abstract)
Pilot Study of Low-Dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: ... (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review (Abstract)