Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A (Abstract) (LDN, low dose naltrexone)
Topical Therapeutic Options in Corneal Neuropathic Pain (Abstract)
Diagnosis and Management of a Hypersensitivity Reaction to Titanium-Containing Surgical Clips... (Abstract)
Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia (Abstract)
The Uses of Low-Dose Naltrexone in Clinical Practice (Abstract)
Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders (Abstract)
The long-term survival of a patient with pancreatic cancer with metastases to the liver... (Abstract)
A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence (Abstract)
Effects of low-dose naltrexone on feed intake, growth, endocrine and immune... (Abstract)
Early outcomes following low dose naltrexone enhancement of opioid detoxification (Abstract)
The Long Term Suppression of Experimental Autoimmune Encephalomyelitis... (Abstract)
Naltrexone modulates growth in infant rats )Abstract)
Impact of Low Dose Naltrexone (LDN) on antiretroviral therapy (ART) treated HIV+ adults... (Abstract)
Low-dose naltrexone (LDN)—review of therapeutic utilization (Abstract)
Response to: Invasive Treatments for Low Back Disorders and the ACOEM Practice Guidelines (Abstract)
An Update on the Uses of Naltrexone in Clinical Practice (Abstract)
Current pharmacotherapeutic properties of low-dose naltrexone therapy in humans and possible therapeutic and prophylactic indications in cats and dogs
Ameliorative response to detoxification, psychotherapy, and medical management in patients maintained on opioids for pain (Abstract)
Naltrexone and Dysphoria: Fact or Myth? (Abstract)
Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone (Abstract)
Naltrexone plasma levels, clinical response and effect on weight in autistic children (Abstract)
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone (Abstract)
Treatment of clinically isolated syndrome with Low Dose Naltrexone (Abstract)
Low-Dose Naltrexone in Diseases' Treatment: Global Review (Abstract)
Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion (Abstract)
Opioid antagonist-induced regulation of organ development (Abstract)
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer ... (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia: protocol for... (Abstract)
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic... (Abstract)
Pilot Study of Low-Dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: ... (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits... (Abstract)
Low dose naltrexone in the treatment of fibromyalgia (Abstract)
Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis (Abstract)
Placebo-controlled acute dosage naltrexone study in young autistic children (Abstract)
Variable Response to Naltrexone in Patients With Hailey-Hailey Disease (Abstract)
Duration of opioid receptor blockade determines biotherapeutic response (Abstract)
Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis (Abstract)
Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution ... (Abstract)
Opioid antagonist modulation of murine neuroblastoma... (Abstract)
What Do Primary Care Providers and Nurses Need to Know About Managing Chronic Pain? (Abstract)
Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review" (Abstract)
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction? (Abstract)
Low-Dose Naltrexone in Rheumatological Diseases (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review (Abstract)
The Lowdown on Low-Dose Naltrexone (Abstract)
Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis (Abstract)
Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+ (Study)
Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder ... (Abstract)
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal (Abstract)
Neuropathic Corneal Pain: Approaches for Management (Abstract)
The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia (Abstract)
Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause? (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report (Abstract)
Naltrexone at low doses (LDN) and its relevance to cancer therapy (Abstract)
Treatment-resistant immune thrombocytopenic purpura associated with LDN use in a patient with MS (Abstract)
Long-Term Effects of Low-Dose Naltrexone on Immunomodulatory Properties of ... (Abstract)
Low-Dose Naltrexone Use in Biopsy-Proven Lichen Planus of the Nails
Efficacy of Low Dose Naltrexone in Psoriasis (Abstract)
Improvement of Hailey-Hailey disease with low-dose naltrexone (Abstract)
Research on low dosage naltrexone (Abstract)
The effects of naltrexone in autistic children: report of two cases (Abstract)
Chapter 8 Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis (Abstract)
Herpes simplex virus
Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease... (Abstract)
Low dose naltrexone for induction of remission in Crohn's disease (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol ... (Abstract)
Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice (Abstract)
Central nervous system infectious diseases mimicking multiple sclerosis:... (Abstract)
Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study (Abstract)
Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions... (Abstract)
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination... (Abstract)
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes (Abstract)
Severe pruritus of cholestasis in disseminated cancer... (Abstract)
Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study (Abstract)
Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease? (Abstract)
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain (Abstract)
Low Dose Naltrexone in Dermatology (Abstract)
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients (Abstract)
ALSUntangled No. 8: Low dose naltrexone for ALS (Abstract)
Complex Regional Pain Syndrome: A Comprehensive Review (Abstract)
What Could Be a Primary Cause of Multiple Sclerosis: Is It an Autoimmunity Triggered by Chronic Protozoan Infection? (Abstract)
Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy... (Abstract)
Low-dose naltrexone as treatment for epidermolysis bullosa pruriginosa-associated refractory pruritus (Abstract)
Resolution of treatment-refractory depression with naltrexone augmentation of paroxetine - a case report (Abstract)
Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells (Abstract)
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis (Abstract)
The effects of chronic naltrexone treatment in young autistic children... (Abstract)
In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain... (Abstract)
A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain (Abstract)
The Use of Low-Dose Naltrexone for Chronic Pain (Abstract)
Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Corticotropin-releasing hormone and the blood-brain-barrier (Abstract)
A randomized, double-blind, placebo-controlled, hybrid parallel-arm study of low-dose naltrexone as an adjunctive anti-inflammatory treatment for major depressive disorder (Abstract)
Is low-dose naltrexone effective in chronic pain management? (Abstract)