Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study

J Clin Gastroenterol
01 April 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586944/

Background
There is an unmet need for safe and effective medicines to treat children with Crohn’s disease. Recently, investigations have shown an association between endogenous opioid peptides and inflammatory cells.

Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment

Invest New Drugs
August 2013
https://pubmed.ncbi.nlm.nih.gov/23275062/

Fibromyalgia, autism, and opioid addiction as natural and induced disorders of the endogenous opioid hormonal system

Discov Med
October 2014
https://www.discoverymedicine.com/Brian-Johnson-2/2014/10/fibromyalgia-autism-and-opioid-addiction-as-natural-and-induced-disorders-of-the-endogenous-opioid-hormonal-system/

Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause?

Med Hypotheses
February 2006
https://pubmed.ncbi.nlm.nih.gov/16759815/

Inducible nitric oxide synthase is thought to be responsible for inflammatory nitric oxide concentrations in the brains of patients with MS and those with autism. It is proposed that low-dose naltrexone reduces nitric oxide synthase, thus acts as an anti-inflammatory agent.
 

Mast cell activation and autism

Biochim Biophys Acta
January 2012
https://www.sciencedirect.com/science/article/pii/S0925443910002954

Morphine reduced perceived anger from neutral and implicit emotional expressions

Psychoneuroendocrinology
May 2018
https://pubmed.ncbi.nlm.nih.gov/29550675/

Low-dose naltrexone for disease prevention and quality of life

Med Hypotheses
March 2009
https://pubmed.ncbi.nlm.nih.gov/19041189/

Low-Dose Naltrexone in Diseases' Treatment: Global Review

Etiological Pathways Toward Autism and Diversities of Treatments: From Unimodal to Multidimensional Approaches

Neuropsychoanalysis
February 2016
http://www.tandfonline.com/doi/abs/10.1080/15294145.2016.1156388

Naltrexone in young autistic children: replication study and learning measures

J Am Acad Child Adolesc Psychiatry
November 1997
https://www.ncbi.nlm.nih.gov/pubmed/?term=19393386

Objective: This study expanded upon previous work on naltrexone efficacy and safety in young autistic children and assessed performance on learning measures.