Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)
Complex Regional Pain Syndrome: A Comprehensive Review (Abstract)
What Could Be a Primary Cause of Multiple Sclerosis: Is It an Autoimmunity Triggered by Chronic Protozoan Infection? (Abstract)
Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy... (Abstract)
Low-dose naltrexone as treatment for epidermolysis bullosa pruriginosa-associated refractory pruritus (Abstract)
Resolution of treatment-refractory depression with naltrexone augmentation of paroxetine - a case report (Abstract)
Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells (Abstract)
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis (Abstract)
The effects of chronic naltrexone treatment in young autistic children... (Abstract)
In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain... (Abstract)
A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain (Abstract)
The Use of Low-Dose Naltrexone for Chronic Pain (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Corticotropin-releasing hormone and the blood-brain-barrier (Abstract)
A randomized, double-blind, placebo-controlled, hybrid parallel-arm study of low-dose naltrexone as an adjunctive anti-inflammatory treatment for major depressive disorder (Abstract)
Is low-dose naltrexone effective in chronic pain management? (Abstract)
Low-Dose Naltrexone Gaining Recognition as Chronic Pain Treatment
Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis (Abstract)
Enkephalin Therapy Improves Relapsing-Remitting Multiple Sclerosis (Abstract)
Oral naltrexone to enhance analgesia in patients receiving continuous intrathecal morphine for chronic pain... (Abstract)
Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form (Abstract)
Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
Opioid receptor system contributes to the acute and sustained antidepressant-like effects... (Abstract)
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases (Abstract)
Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic (Abstract)
Patients' Perspective, Quality of Life and Treatment Goals in Hailey-Hailey Disease... (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia... (Abstract)
Low‐dose naltrexone for the treatment of fibromyalgia... (Abstract)
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis... (Abstract)
Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children (Abstract)
Pilot study into low dose naltrexone (LDN) and NAD+ for treatment of patients with post-COVID-19 syndrome (Study)
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone (Abstract)
Chronic central nervous system involvement in Lyme borreliosis (Abstract)
Thyroid, Diet, and Alternative Approaches (Abstract)
Naltrexone 6 mg Once Daily Versus Placebo in Women with Fibromyalgia: A Randomised, Double-Blind, Placebo-Controlled Trial (Abstract)
Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic (Abstract)
Off-label, Low-Dose Naltrexone for Refractory Chronic Low Back Pain (Abstract)
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice... (Abstract)
Naltrexone in autistic children: behavioral symptoms and attentional learning (Abstract)
Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Abstract)
A novel glial cell inhibitor, low dose naltrexone, reduces pain and depression... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
Successful treatment of dermatomyositis with low-dose naltrexone (Abstract)
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma (Abstract)
Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease... (Abstract)
A Narrative Review of Therapies for Scalp Dermatomyositis (Abstract) (LDN, low dose naltrexone)
Depression in Fibromyalgia Patients May Require Low-Dose Naltrexone to Respond... (Abstract)
Compounding for the Treatment of COVID-19 and Long COVID, Part 2... (Abstract)
Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study (Abstract)
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone (Abstract)
Proceedings #47: Low Dose Naltrexone: A Viable Alternative for Long Term Chronic Pain? (Abstract)
Effect of naltrexone upon self-injurious behavior, learning and activity: a case study (Abstract)
Hailey-Hailey Disease with Superimposed Eczema Herpeticum... (Abstract)
Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy (Abstract)
Hailey-Hailey disease treated successfully with naltrexone and magnesium (Abstract)
Low-dose naltrexone: A possible safe effective treatment for autoimmune disease and cancer (Abstract)
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma... (Abstract)
Low-Dose Naltrexone (LDN) Treatment for Crohn's Disease (CD)... (Abstract)
Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia (Abstract)
The state-of-the-art pharmacotherapeutic options for the treatment of chronic non-cancer pain (Abstract)
Surmounting withdrawal to initiate fast treatment with naltrexone (SWIFT)... (Abstract)
Low-dose Naltrexone (LDN) extends healthspan and lifespan in C. elegans via SKN-1 activation
Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management (Abstract)
Naltrexone could alleviate depression symptoms in patients who relapsed while taking antidepressants (Abstract)
Identfication and Treatment of New Inflammatory Triggers for Complex Regional Pain Syndrome... (Abstract)
Oxytrex: an oxycodone and ultra-low-dose naltrexone formulation (Abstract)
Problem drinking and low-dose naltrexone-assisted opioid detoxification (Abstract)
Low-Dose Naltrexone in newly diagnosed high-grade glioma... (Abstract)
Opioid antagonists as potential therapeutics for ischemic stroke (Abstract)
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer ... (Abstract)
Endogenous opioid systems regulate cell proliferation in the developing rat brain (Abstract)
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients (Abstract)
Opioid Antagonist in the Treatment of Ischemic Stroke (Abstract)
Use of Off-Label Drugs and Nutrition Supplements among Patients with Amyotrophic Lateral Sclerosis in Norway (Abstract)
Treating Long-COVID Brain Fog With ME/CFS Guidelines (Abstract)
Neuroprotective effects of naltrexone in a mouse model of post-traumatic seizures
The Neuropsychoanalytic Approach: Using Neuroscience as the Basic Science of Psychoanalysis (Abstract)
Low-dose Naltrexone Targets the Opioid Growth Factor... (Abstract)
Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis (Abstract)
Preliminary study of altered skin temperature at body sites associated with self-injurious behavior... (Abstract)
Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain (Abstract)
Initial Findings of an Open-Label Trial of Low-Dose Naltrexone for Symptomatic Mesenteric Panniculitis (Abstract)
Enhancing acupuncture by low dose naltrexone (Abstract)
Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis... (Abstract)
Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone (Abstract)
The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia (Abstract)