Clinical Trials

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review

Condition: Fibromyalgia, LDN Radio Show, Pain

Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review

Condition: Hailey Hailey, Hailey-Hailey, LDN Radio Show, Pemphigus

Low-Dose Naltrexone Reverses Facial Mechanical Allodynia in a Rat Model of Trigeminal Neuralgia

Condition: Neuropathy, Pain

Sjogren's Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports

Condition: Dry Eye, Pain, Sjogren's Syndrome

Synergistic PXT3003 Therapy Uncouples Neuromuscular Function From Dysmyelination in Male Charcot-Marie-Tooth Disease Type 1A (CMT1A) Rats

Condition: Charcot Marie Tooth, Charcot-Marie-Tooth

Low-dose Naltrexone Inhibits the Epithelial-Mesenchymal Transition of Cervical Cancer Cells in Vitro and Effects Indirectly on Tumor-Associated Macrophages in Vivo

Condition: Cancer

Efficacy of Low Dose Naltrexone in Psoriasis

Condition: Psoriasis

The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris; a randomized controlled clinical trial

Condition: Autoimmune, Lichen, Skin

The Benefits of Low Dose Naltrexone

Condition: Autoimmune, Crohn’s, Fibromyalgia, Irritable Bowel Syndrome, Lupus, Lupus Erythematosus, Lyme Disease, MS, Multiple Sclerosis, Pain, PCOS, Polycystic Ovary Syndrome, RA, Rheumatoid, Rheumatoid arthritis, RSD

Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone

Condition: Pain, Skin

Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice: A Role for Opioidergic and Nitrergic Transmissions

Condition: Opiod, Seizure

Effects of Acute and Repeated Treatment With Methocinnamox, a Mu Opioid Receptor Antagonist, on Fentanyl Self-Administration in Rhesus Monkeys

Condition: Opiod, Pain

129 Medication Assisted Treatment Protocol

Condition: Opiod, Pain

Low-dose Naltrexone Therapy for Psoriasis

Condition: Autoimmune, Skin, Psoriasis

Transition of Patients With Opioid Use Disorder From Buprenorphine to Extended-Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens

Condition: Opiod, Pain

Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules

Condition: Complex Regional Pain Syndrome, Fibromyalgia, Pain, Psoriasis

Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis by increasing M1-type macrophages and activating the Bax/Bcl-2/caspase-3/PARP pathway.

Condition: Cancer, Carcinoma, Colon

Low‐dose naltrexone in Hailey–Hailey disease: the importance of dosing

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus, Skin

Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships [Online ahead of print]

Condition: Fibromyalgia

Enkephalin Therapy Improves Relapsing-Remitting Multiple Sclerosis

Condition: Multiple Sclerosis

Low-Dose Naltrexone Reduces Symptoms in Stiff-Person Syndrome

Condition: Stiff Person

Improvement of Hailey-Hailey Disease With Low-Dose Naltrexone

Condition: Hailey-Hailey

The Lowdown on Low-Dose Naltrexone

Condition: Dermatitis, Hailey Hailey, Hailey-Hailey, Lichen, Pemphigus, Pruritus, Psoriasis, Skin

Low-dose Naltrexone as a Treatment for Chronic Fatigue Syndrome

Condition: Chronic Fatigue Syndrome

Opioid-induced Hypogonadism: Pathophysiology, Clinical and Therapeutics Review

Condition: Opiod

The effect of low-dose naltrexone on solid Ehrlich carcinoma in mice: The role of OGFr, BCL2, and immune response

Condition: Cancer

Very Low Dose Naltrexone in Opioid Detoxification: A Double-Blind, Randomized Clinical Trial of Efficacy and Safety

Condition: Opiod

Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Condition: CFS, Fatigue, ME, ME/CFS

Long-term benefit from immune modulation and anti-inflammatory treatment in metastatic mesothelioma

Condition: Cancer

Dose Escalation of Naltrexone to Reduce Stress Responses Associated With Opioid Antagonist Induction: A Double-blind Randomized Trial

Condition: Osteoporosis

Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients

Condition: Fatigue, ME, ME/CFS

Hailey-Hailey Disease with Superimposed Eczema Herpeticum Caused by Herpes Simplex Virus Type 2 Infection in a Burn Unit: A Case Report and Literature Review

Condition: Eczema, Hailey Hailey, Hailey-Hailey, Herpes

Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

Condition: Autoimmune

In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis

Condition: Psoriasis, Skin

Low-dose naltrexone safe, effective for neuropathic corneal pain

Condition: Dry Eye, Pain

Recalcitrant Hailey-Hailey disease treated with low-dose naltrexone

Condition: Hailey Hailey, Hailey-Hailey, Pemphigus

Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain

Condition: Eye, Neuropathy, Pain

In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis

Condition: Psoriasis

Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study

Condition: Depression, Epilepsy

Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study

Condition: Arthritis, Rheumatoid, Rheumatoid arthritis

A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain at a Single Institution

Condition: Pain

Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study

Condition: IBD, Inflammatory Bowel Disease