Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

The Neuropsychoanalytic Approach: Using Neuroscience as the Basic Science of Psychoanalysis (Abstract)
Low-dose Naltrexone Targets the Opioid Growth Factor... (Abstract)
Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis (Abstract)
Preliminary study of altered skin temperature at body sites associated with self-injurious behavior... (Abstract)
Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain (Abstract)
Initial Findings of an Open-Label Trial of Low-Dose Naltrexone for Symptomatic Mesenteric Panniculitis (Abstract)
Enhancing acupuncture by low dose naltrexone (Abstract)
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer ... (Abstract)
Endogenous opioid systems regulate cell proliferation in the developing rat brain (Abstract)
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients (Abstract)
Opioid Antagonist in the Treatment of Ischemic Stroke (Abstract)
Response to: Invasive Treatments for Low Back Disorders and the ACOEM Practice Guidelines (Abstract)
An Update on the Uses of Naltrexone in Clinical Practice (Abstract)
MS breakthrough: Cancer drug repairs damaged myelin nerve tissue in human trials first
Does Naltrexone Treatment Lead to Depression?... (Abstract)
Brief report: six months continuation treatment in naltrexone-responsive children with autism... (Abstract)
Sequential analysis of the effects of naltrexone on the environmental mediation of self-injurious behavior (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Endogenous opioid inhibition of proliferation of T and B cell subpopulations... (Abstract)
Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases (Abstract)
Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis... (Abstract)
Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone (Abstract)
The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia (Abstract)
Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology... (Abstract)
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic... (Abstract)
Pilot Study of Low-Dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: ... (Abstract)
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review (Abstract)
Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships (Abstract)
Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer (Abstract)
Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis (Abstract)
Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis (Abstract)
Naltrexone's Impact on Cancer Progression and Mortality... (Abstract)
Systemic administration of low-dose naltrexone increases bone mass due to... (Abstract)
The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
Bee Venom Therapy and Low Dose Naltrexone for Treatment of Multiple Sclerosis (Abstract)
Efficacy of naltrexone in borderline personality disorder, a retrospective analysis in inpatients
Dermpath & Clinic: Hailey Hailey disease treated with low-dose naltrexone (LDN, low dose naltrexone)
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction? (Abstract)
Low-Dose Naltrexone in Rheumatological Diseases (Abstract)
The Benefits of Low Dose Naltrexone (Abstract)
Opioid-induced hypogonadism: Pathophysiology, clinical and therapeutics review (Abstract)
Oxycodone combined with opioid receptor antagonists: efficacy and safety (Abstract)
Efficacy and safety of naltrexone use in pediatric patients with autistic disorder (Abstract)
Double-blinded placebo-controlled cross-over pilot trial of naltrexone to treat Gulf War Illness (Abstract)
Treating Lupus Naturally
The Use of Naltrexone in Dermatology. Current Evidence and Future Directions (Abstract)
Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis (Abstract)
The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis... (Abstract)
Preclinical and clinical studies into the bioactivity of low-dose naltrexone (LDN) for oncotherapy (Abstract)
Effects of low-dose naltrexone on quality of life in high-grade glioma patients... (Abstract)
Treatment-resistant immune thrombocytopenic purpura associated with LDN use in a patient with MS (Abstract)
Long-Term Effects of Low-Dose Naltrexone on Immunomodulatory Properties of ... (Abstract)
Sjogren's Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports (Abstract)
Treating chronic pain with low dose naltrexone and ultralow dose naltrexone: a review paper (Abstract)
Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children (Abstract)
Psychopharmacology of aggression in children and adolescents with autism... (Abstract)
Alteration of prescription-only drug utilization by low dose naltrexone users with hypothyroidism... (Abstract)
Improvement in Hailey-Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report (Abstract)
Inexpensive Compounding of Low-Dose Naltrexone With Orange Juice (Abstract)
Mast cell activation and autism (Abstract)
Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease... (Abstract)
Updates on the Treatment of Erythrodermic Psoriasis (Abstract)
Nematode filarial Worms in cerebrospinal fluid of a Multiple Sclerosis Patient at Autopsy (Poster)
Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study (Abstract)
Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions... (Abstract)
LDN and Pain Paper
Naltrexone Accelerates Full‐Thickness Cutaneous Wound Healing by Enhancing Remodeling (Abstract)
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia (Abstract)
Neuroimmunotherapy of untreatable metastatic solid tumors with subcutaneous low-dose interleukin-2... (Abstract)
Novel and emerging treatments for autism spectrum disorders: a systematic review (Abstract)
Potential drug interaction with opioid agonist in the setting of chronic low-dose opioid antagonist use (Abstract)
Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone... (Abstract)
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth... (Abstract)
The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation... (Abstract)
Fibromyalgia, autism, and opioid addiction as natural and induced disorders of ... (Abstract)
Extended-release naltrexone for youth with opioid use disorder (Abstract)
Recovery from Chronic Demyelination by Thyroid Hormone Therapy... (Abstract)
Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy... (Abstract)
Low-dose naltrexone as treatment for epidermolysis bullosa pruriginosa-associated refractory pruritus (Abstract)
Tracking the spread of Parkinson’s proteins from gut to brain
Low dose naltrexone in the treatment of dissociative symptoms (Abstract)
Bernard Bihari, MD: Low-Dose Naltrexone for normalizing immune system function (Abstract)
Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis... (Abstract)
Naltrexone in young autistic children: replication study and learning measures (Abstract)
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway... (Abstract)
Low-dose naltrexone: a novel adjunctive treatment in symptomatic alopecias? (Abstract)
The uses of naltrexone in dermatologic conditions (Abstract)
Psychoneuroimmunological approach to gastrointestinal related pain IAbstract)
Metabolic treatment of cancer: intermediate results of a prospective case series (Abstract)
Psychopharmacologic Therapies for Irritable Bowel Syndrome (Abstract)
Lyme borreliosis and multiple sclerosis: any connection? A seroepidemic study (Abstract)
A randomized, double-blind, placebo-controlled, hybrid parallel-arm study of low-dose naltrexone as an adjunctive anti-inflammatory treatment for major depressive disorder (Abstract)
Is low-dose naltrexone effective in chronic pain management? (Abstract)
Effects of Naloxone and Naltrexone on Locomotor Activity in C57BL/6 and DBA/2 Mice (Abstract)
Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series (Abstract)
Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules (Abstract)
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin (Abstract)
Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19 (Study)
Naltrexone at low doses upregulates a unique gene expression... (Abstract)
Safety and tolerability of ALO-02 (oxycodone hydrochloride and sequestered naltrexone hydrochloride)... (Abstract)