Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Neuropathic Corneal Pain: Approaches for Management (Abstract)
The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia (Abstract)
Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause? (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review" (Abstract)
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction? (Abstract)
Low-Dose Naltrexone in Rheumatological Diseases (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Low-dose Naltrexone for the treatment of sarcoidosis (Abstract)
The use of Low-Dose Naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain (Abstract)
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects (Abstract)
Low-dose naltrexone effects on plasma chemistries and... (Abstract)
Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder ... (Abstract)
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal (Abstract)
Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease... (Abstract)
Low dose naltrexone for induction of remission in Crohn's disease (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol ... (Abstract)
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report (Abstract)
Naltrexone at low doses (LDN) and its relevance to cancer therapy (Abstract)
Treatment-resistant immune thrombocytopenic purpura associated with LDN use in a patient with MS (Abstract)
Long-Term Effects of Low-Dose Naltrexone on Immunomodulatory Properties of ... (Abstract)
Low-Dose Naltrexone Use in Biopsy-Proven Lichen Planus of the Nails
Low-Dose Naltrexone Reverses Facial Mechanical Allodynia in a Rat Model of Trigeminal Neuralgia (Abstract)
Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome (Abstract)
Naltrexone and communication skills in young children with autism (Abstract)
Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS (Abstract)
Chapter 8 Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis (Abstract)
Herpes simplex virus
Low Dose Naltrexone in Dermatology (Abstract)
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients (Abstract)
ALSUntangled No. 8: Low dose naltrexone for ALS (Abstract)
Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice (Abstract)
Central nervous system infectious diseases mimicking multiple sclerosis:... (Abstract)
Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study (Abstract)
Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions... (Abstract)
Pseudo-endocrine Disorders: Recognition, Management, and Action
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease? (Abstract)
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain (Abstract)
The Use of Low-Dose Naltrexone for Chronic Pain (Abstract)
Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)
Complex Regional Pain Syndrome: A Comprehensive Review (Abstract)
What Could Be a Primary Cause of Multiple Sclerosis: Is It an Autoimmunity Triggered by Chronic Protozoan Infection? (Abstract)
Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy... (Abstract)
Low-dose naltrexone as treatment for epidermolysis bullosa pruriginosa-associated refractory pruritus (Abstract)
Low-Dose Naltrexone for Managing Pain and Autonomic Symptoms in Patients With Dysautonomia
Abstract #13: Low-Dose Naltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study (Abstract)
Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial (Abstract)
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling (Abstract)
Low dose naltrexone (LDN) enhances maturation of bone marrow dendritic cells (BMDCs) (Abstract)
In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain... (Abstract)
A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Corticotropin-releasing hormone and the blood-brain-barrier (Abstract)
A randomized, double-blind, placebo-controlled, hybrid parallel-arm study of low-dose naltrexone as an adjunctive anti-inflammatory treatment for major depressive disorder (Abstract)
Is low-dose naltrexone effective in chronic pain management? (Abstract)
Warning - Fake Medications
Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease) (Abstract)
Low-dose Naltrexone Therapy for Psoriasis (Abstract)
Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone (Abstract)
Opioid-immune interactions in autism... (Abstract)
Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
Opioid receptor system contributes to the acute and sustained antidepressant-like effects... (Abstract)
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases (Abstract)
Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic (Abstract)
Patients' Perspective, Quality of Life and Treatment Goals in Hailey-Hailey Disease... (Abstract)
Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills? (Abstract)
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone(Abstract)
Low‐dose naltrexone in Hailey–Hailey disease: the importance of dosing (Abstract)
Naltrexone in autistic children: an acute open dose range tolerance trial (Abstract)
Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity (Abstract)
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone (Abstract)
Chronic central nervous system involvement in Lyme borreliosis (Abstract)
Thyroid, Diet, and Alternative Approaches (Abstract)
Naltrexone 6 mg Once Daily Versus Placebo in Women with Fibromyalgia: A Randomised, Double-Blind, Placebo-Controlled Trial (Abstract)
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review (Abstract)
Successful induction of ovulation in normogonadotrophic clomiphene resistant anovulatory women... (Abstract)
The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris... (Abstract)
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF)... (Abstract)
Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Abstract)
A novel glial cell inhibitor, low dose naltrexone, reduces pain and depression... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
Successful treatment of dermatomyositis with low-dose naltrexone (Abstract)
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma (Abstract)