Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

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Below you will find a list of published papers, which we will update as they become available.

Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis... (Abstract)
Naltrexone in young autistic children: replication study and learning measures (Abstract)
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway... (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Tracking the spread of Parkinson’s proteins from gut to brain
Low dose naltrexone in the treatment of dissociative symptoms (Abstract)
Bernard Bihari, MD: Low-Dose Naltrexone for normalizing immune system function (Abstract)
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin (Abstract)
Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19 (Study)
Naltrexone at low doses upregulates a unique gene expression... (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
Opioid receptor system contributes to the acute and sustained antidepressant-like effects... (Abstract)
Effects of Naloxone and Naltrexone on Locomotor Activity in C57BL/6 and DBA/2 Mice (Abstract)
Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series (Abstract)
Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules (Abstract)
Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers (Abstract)
The effect of low-dose naltrexone on solid Ehrlich carcinoma in mice: The role of OGFr, BCL2, and immune response (Abstract)
Etiological Pathways Toward Autism and Diversities of Treatments... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone (Abstract)
[Met 5]-enkephalin preserves diffusion metrics in EAE mice (Abstract)
Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex (Abstract)
129 Medication Assisted Treatment Protocol (Abstract)
Naltrexone in autistic children: a double-blind and placebo-controlled study (Abstract)
Low-dose naltrexone augmentation of nicotine replacement (Abstract)
No Antagonists for an Antagonist: One Pitfall of Chronic Oral Low-Dose Naltrexone (Abstract)
Hailey-Hailey disease treated successfully with naltrexone and magnesium (Abstract)
Successful treatment of dermatomyositis with low-dose naltrexone (Abstract)
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma (Abstract)
Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease... (Abstract)
A Narrative Review of Therapies for Scalp Dermatomyositis (Abstract) (LDN, low dose naltrexone)
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study (Abstract)
Low-dose Naltrexone as a Treatment for Chronic Fatigue Syndrome (Abstract)
Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone (Abstract)
Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study (Abstract)
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures (Abstract)
Low Dose Naltrexone (LDN): New in the treatment of chronic pain syndromes... (Abstract)
Opioid antagonists as potential therapeutics for ischemic stroke (Abstract)
Low-dose naltrexone: A possible safe effective treatment for autoimmune disease and cancer (Abstract)
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma... (Abstract)
Low-Dose Naltrexone (LDN) Treatment for Crohn's Disease (CD)... (Abstract)
Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia (Abstract)
Naltrexone a potential therapeutic candidate for COVID-19 (Abstract)
Low Dose Naltrexone in the Treatment of HIV Infection (Abstract)
Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes... (Abstract)
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of... (Abstract)
Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function... (Abstract)
Low Dose Naltrexone for Treatment of Multiple Sclerosis... (Abstract)
Enhancing acupuncture by low dose naltrexone (Abstract)
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer ... (Abstract)
Endogenous opioid systems regulate cell proliferation in the developing rat brain (Abstract)
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients (Abstract)
Opioid Antagonist in the Treatment of Ischemic Stroke (Abstract)
Low-dose naltreoxone for the treatment of irritable bowel syndrome: a pilot study (Abstract)
The opioid antagonist naltrexone improves murine inflammatory bowel disease (Abstract)
Naltrexone open trial with a 5-year-old-boy. A social rebound reaction (Abstract)
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects (Abstract)
Low-dose naltrexone effects on plasma chemistries and... (Abstract)
Potential antidepressant role of low-dose naltrexone in a rat model of chronic unpredictable mild stress (Abstract)
Low dose naltrexone in refractory neuropathic pain associated with autoimmune transverse myelitis (Abstract)
Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases (Abstract)
Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis... (Abstract)
Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone (Abstract)
The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia (Abstract)
Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology... (Abstract)
Low-dose Naltrexone for the treatment of sarcoidosis (Abstract)
The use of Low-Dose Naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain (Abstract)
Naltrexone and communication skills in young children with autism (Abstract)
Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS (Abstract)
Low Dose Naltrexone for Neuropathic Pain Related to an Electrical Burn Injury: A Case Study (Article)
Press Release: WAYT-less™ by Nu Image Medical® Exceeds All Projections for Q4 2020
Systemic administration of low-dose naltrexone increases bone mass due to... (Abstract)
The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
Bee Venom Therapy and Low Dose Naltrexone for Treatment of Multiple Sclerosis (Abstract)
Efficacy of naltrexone in borderline personality disorder, a retrospective analysis in inpatients
Dermpath & Clinic: Hailey Hailey disease treated with low-dose naltrexone (LDN, low dose naltrexone)
Low-Dose Naltrexone Reverses Facial Mechanical Allodynia in a Rat Model of Trigeminal Neuralgia (Abstract)
Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Disease remission after commencing naltrexone in an atypical case of Crohn’s disease... (Abstract)
Low Dose Naltrexone, A Helpful Option to Battle Depression & Anxiety
The Use of Naltrexone in Dermatology. Current Evidence and Future Directions (Abstract)
Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis (Abstract)
The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis... (Abstract)
Preclinical and clinical studies into the bioactivity of low-dose naltrexone (LDN) for oncotherapy (Abstract)
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling (Abstract)
Low dose naltrexone (LDN) enhances maturation of bone marrow dendritic cells (BMDCs) (Abstract)