Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

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Below you will find a list of published papers, which we will update as they become available.

Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review (Abstract)
Successful induction of ovulation in normogonadotrophic clomiphene resistant anovulatory women... (Abstract)
The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris... (Abstract)
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF)... (Abstract)
Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization (Abstract)
Low-Dose Naltrexone: A New Therapy Option for Complex Regional Pain Syndrome Type I Patients (Abstract)
Safety and tolerability of ALO-02 (oxycodone hydrochloride and sequestered naltrexone hydrochloride)... (Abstract)
Efficacy of low dose naltrexone for patients that suffer from comorbid depressive illness (Abstract)
Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets... (Abstract)
Apparent efficacy and safety of low dose naltrexone in Australian patients with active Crohn's disease (Abstract)
A Comparison of Medication-Assisted Treatment Options for Opioid Addiction... (Abstract)
Cytomegalovirus infection exacerbates autoimmune mediated neuroinflammation (Abstract)
Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA (Abstract)
Naltrexone and other potential new pharmacological treatments of autismx (Abstract)
Transition of Patients With Opioid Use Disorder From Buprenorphine to Extended-Release Naltrexone... (Abstract)
Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders (Abstract)
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis (Abstract)
Opioid growth factor and low dose naltrexone impair central nervous system infiltration... (Abstract)
Reversal of signs and symptoms of a B-Cell lymphoma in a patient using only low-dose naltrexone
Naltrexone and nalmefene attenuate cocaine place preference in male mice (Abstract)
Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics (Abstract)
Is fibromyalgia an endocrine/endorphin deficit disorder?... (Abstract)
Low Dose Naltrexone in Conjunction With the Wahls Protocol to Reduce the Frequency of Chronic Migraines... (Abstract)
Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone (Abstract)
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia (Abstract)
The Uses of Low-Dose Naltrexone in Clinical Practice (Abstract)
Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders (Abstract)
The long-term survival of a patient with pancreatic cancer with metastases to the liver... (Abstract)
A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence (Abstract)
Effects of low-dose naltrexone on feed intake, growth, endocrine and immune... (Abstract)
Low-Dose Naltrexone-Induced Remission in Hailey-Hailey Disease Maintained in Remission (Abstract)
Generalized familial benign chronic pemphigus (Hailey-Hailey disease) treated successfully... (Abstract)
Naltrexone modulates tumor response in mice with neuroblastoma (Abstract)
Single cohort study of the effect of Low Dose Naltrexone on the evolution of immunological, virological and clinical... (Abstract)
Darier and Hailey-Hailey disease: update 2021 (Abstract) (LDN, low dose naltrexone)
Depression in Fibromyalgia Patients May Require Low-Dose Naltrexone to Respond... (Abstract)
Ameliorative response to detoxification, psychotherapy, and medical management in patients maintained on opioids for pain (Abstract)
Naltrexone and Dysphoria: Fact or Myth? (Abstract)
Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone (Abstract)
Naltrexone plasma levels, clinical response and effect on weight in autistic children (Abstract)
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone (Abstract)
Treatment of clinically isolated syndrome with Low Dose Naltrexone (Abstract)
Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents... (Abstract)
Low-dose naltrexone suppresses ovarian cancer... (Abstract)
Naltrexone modulates body and brain development in rats... (Abstract)
Low-Dose Naltrexone for Pruritus in Systemic Sclerosis (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer... (Abstract)
The state-of-the-art pharmacotherapeutic options for the treatment of chronic non-cancer pain (Abstract)
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits... (Abstract)
Low dose naltrexone in the treatment of fibromyalgia (Abstract)
Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis (Abstract)
Placebo-controlled acute dosage naltrexone study in young autistic children (Abstract)
Variable Response to Naltrexone in Patients With Hailey-Hailey Disease (Abstract)
Duration of opioid receptor blockade determines biotherapeutic response (Abstract)
Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice (Abstract)
Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy (Abstract)
Modulation of human neuroblastoma transplanted into nude mice... (Abstract)
Low-dose naltrexone plays antineoplastic role in cervical cancer progression... (Abstract)
Prurigo excoriée treated with low dose naltrexone (Abstract)
Use of Off-Label Drugs and Nutrition Supplements among Patients with Amyotrophic Lateral Sclerosis in Norway (Abstract)
Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review (Abstract)
The Lowdown on Low-Dose Naltrexone (Abstract)
Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis (Abstract)
Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+ (Study)
Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder ... (Abstract)
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal (Abstract)
Sjogren's Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy (Abstract)
Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing... (Abstract)
Low dose naltrexone therapy in multiple sclerosis (Abstract)
Influence of low dose naltrexone on Raman assisted bone quality, skeletal advanced glycation... (Abstract)
In Response Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review" (Abstract)
Repurposing low-dose naltrexone (LDN) for the prevention and treatment of immunothrombosis in COVID-19 (Abstract)
Efficacy of Low Dose Naltrexone in Psoriasis (Abstract)
Improvement of Hailey-Hailey disease with low-dose naltrexone (Abstract)
Research on low dosage naltrexone (Abstract)
The effects of naltrexone in autistic children: report of two cases (Abstract)
Chapter 8 Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis (Abstract)
Herpes simplex virus
Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis (Abstract)
Morphine reduced perceived anger from neutral and implicit emotional expressions (Abstract)
Low-dose naltrexone therapy improves active Crohn's disease (Abstract)
Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: ... (Abstract)
Effect of Low-Dose Naltrexone on Egyptian Children with Intractable Epilepsy: A Case Series Study (Abstract)
Recalcitrant cases of Hailey-Hailey disease successfully managed with low-dose naltrexone
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination... (Abstract)
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes (Abstract)
Severe pruritus of cholestasis in disseminated cancer... (Abstract)
Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study (Abstract)
Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease? (Abstract)
A potential anti-inflammatory effect of low-dose naltrexone in fibromyalgia (Abstract)
Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone... (Abstract)
The multifaceted role of astrocytes in regulating myelination (Abstract)
Low-dose naltrexone for treatment of duodenal Crohn's disease in a pediatric patient (Abstract)
Pharmacotherapy of obesity: An update (Abstract)
Study protocol ... examining the add-on efficacy, cost-utility of low-dose naltrexone ... in patients with fibromyalgia (Abstract)
Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project (Abstract)
Resolution of treatment-refractory depression with naltrexone augmentation of paroxetine - a case report (Abstract)
Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells (Abstract)
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis (Abstract)
The effects of chronic naltrexone treatment in young autistic children... (Abstract)