Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

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Below you will find a list of published papers, which we will update as they become available.

Low-Dose Naltrexone in Diseases' Treatment: Global Review (Abstract)
Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion (Abstract)
Opioid antagonist-induced regulation of organ development (Abstract)
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer ... (Abstract)
Low-dose naltrexone (LDN)—review of therapeutic utilization (Abstract)
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic: ... (Abstract)
The Neuropsychoanalytic Approach: Using Neuroscience as the Basic Science of Psychoanalysis (Abstract)
Low-dose Naltrexone Targets the Opioid Growth Factor... (Abstract)
Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis (Abstract)
Preliminary study of altered skin temperature at body sites associated with self-injurious behavior... (Abstract)
Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain (Abstract)
Initial Findings of an Open-Label Trial of Low-Dose Naltrexone for Symptomatic Mesenteric Panniculitis (Abstract)
Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis (Abstract)
Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution ... (Abstract)
Opioid antagonist modulation of murine neuroblastoma... (Abstract)
What Do Primary Care Providers and Nurses Need to Know About Managing Chronic Pain? (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia: protocol for... (Abstract)
Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn's disease... (Abstract)
MS breakthrough: Cancer drug repairs damaged myelin nerve tissue in human trials first
Does Naltrexone Treatment Lead to Depression?... (Abstract)
Brief report: six months continuation treatment in naltrexone-responsive children with autism... (Abstract)
Sequential analysis of the effects of naltrexone on the environmental mediation of self-injurious behavior (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Endogenous opioid inhibition of proliferation of T and B cell subpopulations... (Abstract)
Naltrexone's Impact on Cancer Progression and Mortality... (Abstract)
Neuropathic Corneal Pain: Approaches for Management (Abstract)
The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia (Abstract)
Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause? (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review" (Abstract)
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review (Abstract)
Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships (Abstract)
Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer (Abstract)
Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis (Abstract)
Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis (Abstract)
Treating Lupus Naturally
Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease... (Abstract)
Low dose naltrexone for induction of remission in Crohn's disease (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol ... (Abstract)
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report (Abstract)
Naltrexone at low doses (LDN) and its relevance to cancer therapy (Abstract)
The Benefits of Low Dose Naltrexone (Abstract)
Opioid-induced hypogonadism: Pathophysiology, clinical and therapeutics review (Abstract)
Oxycodone combined with opioid receptor antagonists: efficacy and safety (Abstract)
Efficacy and safety of naltrexone use in pediatric patients with autistic disorder (Abstract)
Double-blinded placebo-controlled cross-over pilot trial of naltrexone to treat Gulf War Illness (Abstract)
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain (Abstract)
Low Dose Naltrexone in Dermatology (Abstract)
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients (Abstract)
ALSUntangled No. 8: Low dose naltrexone for ALS (Abstract)
Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice (Abstract)
Central nervous system infectious diseases mimicking multiple sclerosis:... (Abstract)
Sjogren's Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports (Abstract)
Treating chronic pain with low dose naltrexone and ultralow dose naltrexone: a review paper (Abstract)
Plasma beta-endorphin levels, naltrexone, and haloperidol in autistic children (Abstract)
Psychopharmacology of aggression in children and adolescents with autism... (Abstract)
Alteration of prescription-only drug utilization by low dose naltrexone users with hypothyroidism... (Abstract)
A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain (Abstract)
The Use of Low-Dose Naltrexone for Chronic Pain (Abstract)
Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)
Complex Regional Pain Syndrome: A Comprehensive Review (Abstract)
What Could Be a Primary Cause of Multiple Sclerosis: Is It an Autoimmunity Triggered by Chronic Protozoan Infection? (Abstract)
LDN and Pain Paper
Naltrexone Accelerates Full‐Thickness Cutaneous Wound Healing by Enhancing Remodeling (Abstract)
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia (Abstract)
Neuroimmunotherapy of untreatable metastatic solid tumors with subcutaneous low-dose interleukin-2... (Abstract)
Novel and emerging treatments for autism spectrum disorders: a systematic review (Abstract)
Potential drug interaction with opioid agonist in the setting of chronic low-dose opioid antagonist use (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Corticotropin-releasing hormone and the blood-brain-barrier (Abstract)
Tracking the spread of Parkinson’s proteins from gut to brain
Low dose naltrexone in the treatment of dissociative symptoms (Abstract)
Bernard Bihari, MD: Low-Dose Naltrexone for normalizing immune system function (Abstract)
Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis... (Abstract)
Naltrexone in young autistic children: replication study and learning measures (Abstract)
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway... (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
Opioid receptor system contributes to the acute and sustained antidepressant-like effects... (Abstract)
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases (Abstract)
Effects of Naloxone and Naltrexone on Locomotor Activity in C57BL/6 and DBA/2 Mice (Abstract)
Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series (Abstract)
Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules (Abstract)
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin (Abstract)
Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19 (Study)
Naltrexone at low doses upregulates a unique gene expression... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone (Abstract)
Chronic central nervous system involvement in Lyme borreliosis (Abstract)
[Met 5]-enkephalin preserves diffusion metrics in EAE mice (Abstract)