Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease? (Abstract)
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain (Abstract)
Low Dose Naltrexone in Dermatology (Abstract)
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients (Abstract)
ALSUntangled No. 8: Low dose naltrexone for ALS (Abstract)
Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice (Abstract)
Central nervous system infectious diseases mimicking multiple sclerosis:... (Abstract)
Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study (Abstract)
Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions... (Abstract)
Pseudo-endocrine Disorders: Recognition, Management, and Action
Abstract #13: Low-Dose Naltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study (Abstract)
Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial (Abstract)
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling (Abstract)
Low dose naltrexone (LDN) enhances maturation of bone marrow dendritic cells (BMDCs) (Abstract)
In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain... (Abstract)
A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain (Abstract)
The Use of Low-Dose Naltrexone for Chronic Pain (Abstract)
Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)
Complex Regional Pain Syndrome: A Comprehensive Review (Abstract)
What Could Be a Primary Cause of Multiple Sclerosis: Is It an Autoimmunity Triggered by Chronic Protozoan Infection? (Abstract)
Mesenteric Panniculitis, Sclerosing Mesenteritis and Mesenteric Lipodystrophy... (Abstract)
Low-dose naltrexone as treatment for epidermolysis bullosa pruriginosa-associated refractory pruritus (Abstract)
Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease) (Abstract)
Low-dose Naltrexone Therapy for Psoriasis (Abstract)
Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone (Abstract)
Opioid-immune interactions in autism... (Abstract)
Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Corticotropin-releasing hormone and the blood-brain-barrier (Abstract)
A randomized, double-blind, placebo-controlled, hybrid parallel-arm study of low-dose naltrexone as an adjunctive anti-inflammatory treatment for major depressive disorder (Abstract)
Is low-dose naltrexone effective in chronic pain management? (Abstract)
Warning - Fake Medications
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone(Abstract)
Low‐dose naltrexone in Hailey–Hailey disease: the importance of dosing (Abstract)
Naltrexone in autistic children: an acute open dose range tolerance trial (Abstract)
Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity (Abstract)
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
Opioid receptor system contributes to the acute and sustained antidepressant-like effects... (Abstract)
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases (Abstract)
Low-dose naltrexone reduced anxiety in persons with multiple sclerosis during the COVID-19 pandemic (Abstract)
Patients' Perspective, Quality of Life and Treatment Goals in Hailey-Hailey Disease... (Abstract)
Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills? (Abstract)
Successful induction of ovulation in normogonadotrophic clomiphene resistant anovulatory women... (Abstract)
The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris... (Abstract)
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF)... (Abstract)
Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Abstract)
A novel glial cell inhibitor, low dose naltrexone, reduces pain and depression... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone (Abstract)
Chronic central nervous system involvement in Lyme borreliosis (Abstract)
Thyroid, Diet, and Alternative Approaches (Abstract)
Naltrexone 6 mg Once Daily Versus Placebo in Women with Fibromyalgia: A Randomised, Double-Blind, Placebo-Controlled Trial (Abstract)
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review (Abstract)
Naltrexone and other potential new pharmacological treatments of autism (Abstract)
Transition of Patients With Opioid Use Disorder From Buprenorphine to Extended-Release Naltrexone... (Abstract)
Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders (Abstract)
Hailey-Hailey Disease with Superimposed Eczema Herpeticum... (Abstract)
Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy (Abstract)
Hailey-Hailey disease treated successfully with naltrexone and magnesium (Abstract)
Successful treatment of dermatomyositis with low-dose naltrexone (Abstract)
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma (Abstract)
Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease... (Abstract)
A Narrative Review of Therapies for Scalp Dermatomyositis (Abstract) (LDN, low dose naltrexone)
Depression in Fibromyalgia Patients May Require Low-Dose Naltrexone to Respond... (Abstract)
Compounding for the Treatment of COVID-19 and Long COVID, Part 2... (Abstract)
Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy
Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA (Abstract)
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia (Abstract)
The Uses of Low-Dose Naltrexone in Clinical Practice (Abstract)
Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders (Abstract)
The long-term survival of a patient with pancreatic cancer with metastases to the liver... (Abstract)
Problem drinking and low-dose naltrexone-assisted opioid detoxification (Abstract)
Low-Dose Naltrexone in newly diagnosed high-grade glioma... (Abstract)
Opioid antagonists as potential therapeutics for ischemic stroke (Abstract)
Low-dose naltrexone: A possible safe effective treatment for autoimmune disease and cancer (Abstract)
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma... (Abstract)
Low-Dose Naltrexone (LDN) Treatment for Crohn's Disease (CD)... (Abstract)
Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia (Abstract)
The state-of-the-art pharmacotherapeutic options for the treatment of chronic non-cancer pain (Abstract)
Surmounting withdrawal to initiate fast treatment with naltrexone (SWIFT)... (Abstract)
Low-dose Naltrexone (LDN) extends healthspan and lifespan in C. elegans via SKN-1 activation
Ameliorative response to detoxification, psychotherapy, and medical management in patients maintained on opioids for pain (Abstract)
Naltrexone and Dysphoria: Fact or Myth? (Abstract)
Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone (Abstract)