Clinical Trials

Since the late 1970's there have been many trials and studies carried out on Low Dose Naltrexone, LDN. Below you will find a list of published papers which we will update as they become available.

Date Published: 04/2018

Condition: Multiple Sclerosis

McLaughlin leads research on identifying minimally invasive biomarkers for MS

Condition: Crohn's Disease

Low dose naltrexone for induction of remission in Crohn's disease

Condition: Ulcerative Colitis

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

Condition: N/A

Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study

Condition: Multiple Sclerosis

Low-dose Naltrexone Changes Levels of Inflammatory Proteins in MS, Study Shows

Condition: N/A

Emerging Unconventional Therapies for Alopecia Areata

Condition: Multiple Sclerosis

Featured Article: Modulation of the OGF–OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

Condition: Crohn's Disease, Ulcerative Colitis

The effect of Low Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental before-and-after Prescription Database Study

Condition: Crohn's Disease, Fibromyalgia, Multiple Sclerosis, Pain

The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, fibromyalgia, Crohn's disease, and other chronic pain disorders

Condition: N/A

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

Condition: N/A

Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

Condition: N/A

Emerging Unconventional Therapies for Alopecia Areata

Condition: N/A

Low-dose naltrexone for the treatment of sarcoidosis

Condition: N/A

Co-administration of low-dose naltrexone and bupropion reduces alcohol drinking in alcohol-preferring (P) rats

Condition: N/A

The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol

Condition: N/A

Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris

Condition: N/A

Combination therapy for obesity

Condition: N/A

Psychoneuroimmunological approach to gastrointestinal related pain

Condition: Multiple Sclerosis

Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics.

Condition: Multiple Sclerosis

Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study

Condition: Hailey-Hailey

Treatment of Hailey-Hailey Disease With Low-Dose Naltrexone

Condition: Hailey-Hailey

Low dose naltrexone: a novel treatment for Hailey-Hailey disease

Condition: Crohn's Disease, IBD, Ulcerative Colitis

Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease – A drug utilization cohort study based on the Norwegian prescription register

Condition: Multiple Sclerosis

Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

Condition: Multiple Sclerosis

Low Dose Naltrexone for Treatment of Multiple Sclerosis: A Retrospective Chart Review of Safety and Tolerability

Condition: Generic

Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood.

Condition: Cancer

Duration of Opioid Receptor Blockade Determines Biotherapeutic Response

Condition: Generic

Ultra-Low Doses of Naltrexone Enhance the Antiallodynic Effect of Pregabalin or Gabapentin in Neuropathic Rats.

Condition: N/A

Low-dose Naltrexone for the treatment of sarcoidosis

Condition: N/A

Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone

Condition: Hailey-Hailey

Treatment of Hailey-Hailey Disease With Low-Dose Naltrexone

Condition: Hailey-Hailey

Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease)

Condition: Hailey-Hailey

Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity

Condition: Cancer

Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets following Stimulation with Ligands for Intracellular Toll-Like Receptors.

Condition: Fibromyalgia

In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain, and does it decrease use of oral opioids?

Condition: Hypothyroidism

Alteration of prescription-only drug utilization by low dose naltrexone users with hypothyroidism. A cohort study based on the Norwegian prescription database from 2011-2015

Condition: Crohn's Disease, IBD, Ulcerative Colitis

Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells

Condition: Fibromyalgia

Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia

Condition: Multiple Sclerosis

Potential drug interaction with opioid agonist in the setting of chronic low-dose opioid antagonist use.

Condition: Fibromyalgia

Low-dose naltrexone and opioid consumption: a drug utilization cohort study based on data from the Norwegian prescription database

Condition: Fibromyalgia

Low Dose Naltrexone in the Treatment of Fibromyalgia

Condition: Depression

Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants.

Condition: Generic

The multifaceted role of astrocytes in regulating myelination

Condition: Generic

The multifaceted role of astrocytes in regulating myelination (LDN, low dose naltrexone)

Condition: Crohn's Disease, Fibromyalgia, Multiple Sclerosis

A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study.

Condition: Multiple Sclerosis

Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis

Condition: N/A

Functional modulation on macrophage by low dose naltrexone (LDN)

Condition: Cancer, Glioma

Combination of Metabolic Treatment of Aggressive Primary Brain Tumour and Multiple Metastases of the Brain

Condition: Crohn's Disease

Evaluation of Therapeutic Effect of Low Dose Naltrexone in Experimentally-Induced Crohn's Disease in Rats

Condition: Cancer

Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy

Condition: Cancer

Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy

Condition: CRPS

Low-Dose Naltrexone: A New Therapy Option for Complex Regional Pain Syndrome Type I Patients

Condition: Pain

Identi cation and Treatment of New In ammatory Triggers for Complex Regional Pain Syndrome: Small Intestinal Bacterial Overgrowth and Obstructive Sleep Apnea

Condition: CRPS, Fibromyalgia, Pain

A novel glial cell inhibitor, low dose naltrexone, reduces pain and depression, and improves function in chronic pain: A CHOIR study

Condition: Depression

Published Paper LDN and Depression pager

Condition: Autism

Etiological Pathways Toward Autism and Diversities of Treatments: From Unimodal to Multidimensional Approaches

Condition: CRPS

Identification and Treatment of New Inflammatory Triggers for Complex Regional Pain Syndrome: Small Intestinal Bacterial Overgrowth and Obstructive Sleep Apnea

Condition: Multiple Sclerosis

Opioid growth factor and low dose naltrexone impair central nervous system infiltration by CD4+T lymphocytes in established experimental autoimmune encephalomyelitis, a model of multiple sclerosis

Condition: Diabetic Neuropathy

Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy

Condition: IBD

Low-Dose Naltrexone for the treatment of irritable bowel syndrome: a pilot study

Condition: Pain

No Antagonists for an Antagonist: One Pitfall of Chronic Oral Low-Dose Naltrexone No Antagonists for an Antagonist

Condition: N/A

Effects of low-dose naltrexone on feed intake, growth, endocrine and immune parameters in the recently-weaned pig

Condition: Glioma

Low-Dose Naltrexone in newly diagnosed high-grade glioma: placebo-controlled, double-blind, randomized pilot study

Condition: Pain

Low Dose Naltrexone (LDN): New in the treatment of chronic pain syndromes. What really matters – reduced pain or increased energy?

Condition: Multiple Sclerosis

Treatment of clinically isolated syndrome with Low Dose Naltrexone

Condition: Mesenteric Panniculitis

Initial Findings of an Open-Label Trial of Low-Dose Naltrexone for Symptomatic Mesenteric Panniculitis

Condition: Crohn's Disease, IBD

Low Dose Naltrexone in the Treatment of Crohn's Disease: A Case Series

Condition: N/A

The Use of Naltrexone in Low Doses Beyond the Approved Indication [Internet]

Condition: Pain

The use of Low-Dose Naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

Condition: Multiple Sclerosis

Endogenous opioid inhibition of proliferation of T and B cell subpopulations in response to immunization for experimental autoimmune encephalomyelitis.

Condition: Mesenteric Panniculitis, Pain

Low Dose Naltrexone in refractory neuropathic pain associated with autoimmune transverse myelitis

Condition: Fibromyalgia

A potential anti-inflammatory effect of low-dose naltrexone in fibromyalgia

Condition: Autism

Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study

Condition: Multiple Sclerosis

Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis

Condition: Dissociative Disorder, PTSD

Low Dose Naltrexone in the treatment of dissociative symptoms

Condition: Autism, Fibromyalgia

Fibromyalgia, autism, and opioid addiction as natural and induced disorders of the endogenous opioid hormonal system

Condition: Adenoid Cystic Carcinoma, Cancer

Long-term remission of adenoid cystic tongue carcinoma with Low Dose Naltrexone and vitamin D3--a case report

Condition: Crohn's Disease, Ulcerative Colitis

Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis

Condition: Cancer

Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone and vitamin D3--a case report

Condition: Pain

Off-Label Low-Dose Naltrexone for Refractory Chronic Back Pain

Condition: N/A

Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking in alcohol-preferring (P) and Long Evans rats.

Condition: Pain

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

Condition: Crohn's Disease

Low Dose Naltrexone for induction of remission in Crohn's disease

Condition: Cancer, Cholangiocarcinoma, Esophageal Carcinoma, Parotid Carcinoma, Uterine Sarcoma

Metabolic treatment of cancer: intermediate results of a prospective case series

Condition: Cancer

Metabolic treatment of cancer: intermediate results of a prospective case series

Condition: Crohn's Disease, Ulcerative Colitis

Low Dose Naltrexone in therapy resistant IBD, a case series

Condition: Cancer

Low dose naltrexone (LDN) enhances maturation of bone marrow dendritic cells (BMDCs)

Condition: Ulcerative Colitis

Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis

Condition: Crohn's Disease

Apparent Efficacy and Safety of Low Dose Naltrexone in Australian Patients with Active Crohn's Disease

Condition: Hepatoblastoma

Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment

Condition: Pain

Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin

Condition: Cancer

Pharmacokinetics and dose proportionality of fentanyl sublingual spray: a single-dose 5-way crossover study

Condition: CRPS

Treatment of Complex Regional Pain Syndrome (CRPS) using low dose naltrexone (LDN)

Condition: CRPS

Treatment of Complex Regional Pain Syndrome (CRPS) using Low Dose Naltrexone (LDN)

Condition: Fibromyalgia

Low Dose Naltrexone in the treatment of Fibromyalgia

Condition: Cancer

Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer

Condition: Cancer

Oxycodone combined with opioid receptor antagonists: efficacy and safety

Condition: Fibromyalgia

Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease: a pilot study

Condition: Fibromyalgia

Low-Dose Naltrexone for the treatment of fibromyalgia: findings of a small, randomized, double-blind, placebo-controlled, counterbalanced, crossover trial assessing daily pain levels

Condition: Fibromyalgia

Is fibromyalgia an endocrine/endorphin deficit disorder? Is Low Dose Naltrexone a new treatment option?

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Clinical Trials

Date Published: 04/2018

Condition: Multiple Sclerosis

McLaughlin leads research on identifying minimally invasive biomarkers for MS

Date Published: 04/2018

Condition: Crohn's Disease

Low dose naltrexone for induction of remission in Crohn's disease

Date Published: 03/2018

Condition: Ulcerative Colitis

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

Date Published: 02/2018

Condition: N/A

Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users: A Preliminary Laboratory Study

Date Published: 02/2018

Condition: Multiple Sclerosis

Low-dose Naltrexone Changes Levels of Inflammatory Proteins in MS, Study Shows

Date Published: 01/2018

Condition: N/A

Emerging Unconventional Therapies for Alopecia Areata

Date Published: 01/2018

Condition: Multiple Sclerosis

Featured Article: Modulation of the OGF–OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

Date Published: 01/2018

Condition: Crohn's Disease, Ulcerative Colitis

The effect of Low Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental before-and-after Prescription Database Study

Date Published: 01/2018

Condition: Crohn's Disease, Fibromyalgia, Multiple Sclerosis, Pain

The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, fibromyalgia, Crohn's disease, and other chronic pain disorders

Date Published: 01/2018

Condition: N/A

Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes using naltrexone, immunoglobulin and antibiotic treatment

Date Published: 01/2018

Condition: N/A

Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis

Date Published: 01/2018

Condition: N/A

Emerging Unconventional Therapies for Alopecia Areata

Date Published: 01/2018

Condition: N/A

Low-dose naltrexone for the treatment of sarcoidosis

Date Published: 12/2017

Condition: N/A

Co-administration of low-dose naltrexone and bupropion reduces alcohol drinking in alcohol-preferring (P) rats

Date Published: 12/2017

Condition: N/A

The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol

Date Published: 11/2017

Condition: N/A

Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris

Date Published: 11/2017

Condition: N/A

Combination therapy for obesity

Date Published: 11/2017

Condition: N/A

Psychoneuroimmunological approach to gastrointestinal related pain

Date Published: 11/2017

Condition: Multiple Sclerosis

Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics.

Date Published: 11/2017

Condition: Multiple Sclerosis

Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study

Date Published: 10/2017

Condition: Hailey-Hailey

Treatment of Hailey-Hailey Disease With Low-Dose Naltrexone

Date Published: 10/2017

Condition: Hailey-Hailey

Low dose naltrexone: a novel treatment for Hailey-Hailey disease

Date Published: 09/2017

Condition: Crohn's Disease, IBD, Ulcerative Colitis

Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease – A drug utilization cohort study based on the Norwegian prescription register

Date Published: 09/2017

Condition: Multiple Sclerosis

Featured Article: Serum [Met5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone

Date Published: 09/2017

Condition: Multiple Sclerosis

Low Dose Naltrexone for Treatment of Multiple Sclerosis: A Retrospective Chart Review of Safety and Tolerability

Date Published: 09/2017

Condition: Generic

Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood.