Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Low-Dose Naltrexone (LDN) Treatment for Crohn's Disease (CD)... (Abstract)
Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia (Abstract)
The state-of-the-art pharmacotherapeutic options for the treatment of chronic non-cancer pain (Abstract)
Surmounting withdrawal to initiate fast treatment with naltrexone (SWIFT)... (Abstract)
Low-dose Naltrexone (LDN) extends healthspan and lifespan in C. elegans via SKN-1 activation
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia (Abstract)
The Uses of Low-Dose Naltrexone in Clinical Practice (Abstract)
Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders (Abstract)
The long-term survival of a patient with pancreatic cancer with metastases to the liver... (Abstract)
Problem drinking and low-dose naltrexone-assisted opioid detoxification (Abstract)
Low-Dose Naltrexone in newly diagnosed high-grade glioma... (Abstract)
Opioid antagonists as potential therapeutics for ischemic stroke (Abstract)
Low-dose naltrexone: A possible safe effective treatment for autoimmune disease and cancer (Abstract)
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma... (Abstract)
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients (Abstract)
Opioid Antagonist in the Treatment of Ischemic Stroke (Abstract)
Use of Off-Label Drugs and Nutrition Supplements among Patients with Amyotrophic Lateral Sclerosis in Norway (Abstract)
Treating Long-COVID Brain Fog With ME/CFS Guidelines (Abstract)
Neuroprotective effects of naltrexone in a mouse model of post-traumatic seizures
Ameliorative response to detoxification, psychotherapy, and medical management in patients maintained on opioids for pain (Abstract)
Naltrexone and Dysphoria: Fact or Myth? (Abstract)
Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone (Abstract)
Naltrexone plasma levels, clinical response and effect on weight in autistic children (Abstract)
Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain (Abstract)
Initial Findings of an Open-Label Trial of Low-Dose Naltrexone for Symptomatic Mesenteric Panniculitis (Abstract)
Enhancing acupuncture by low dose naltrexone (Abstract)
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer ... (Abstract)
Endogenous opioid systems regulate cell proliferation in the developing rat brain (Abstract)
The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia (Abstract)
Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology... (Abstract)
Repurposing low-dose naltrexone (LDN) for the prevention and treatment of immunothrombosis in COVID-19 (Abstract)
Segmental Darier's disease: A case report (Abstract)
Unraveling the neuroprotective mechanisms of naltrexone against aluminum-induced neurotoxicity
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits... (Abstract)
Low dose naltrexone in the treatment of fibromyalgia (Abstract)
Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis (Abstract)
Placebo-controlled acute dosage naltrexone study in young autistic children (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Endogenous opioid inhibition of proliferation of T and B cell subpopulations... (Abstract)
Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases (Abstract)
Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis... (Abstract)
Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone (Abstract)
Efficacy of naltrexone in borderline personality disorder, a retrospective analysis in inpatients
Dermpath & Clinic: Hailey Hailey disease treated with low-dose naltrexone (LDN, low dose naltrexone)
Recalcitrant cases of Hailey-Hailey disease successfully managed with low-dose naltrexone
A systematic literature review on the clinical efficacy of low dose naltrexone ... (Abstract)
Efficacy and safety of low-dose naltrexone for the management of fibromyalgia: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis
Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review (Abstract)
The Lowdown on Low-Dose Naltrexone (Abstract)
Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis (Abstract)
Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+ (Study)
Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis (Abstract)
Naltrexone's Impact on Cancer Progression and Mortality... (Abstract)
Systemic administration of low-dose naltrexone increases bone mass due to... (Abstract)
The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
Bee Venom Therapy and Low Dose Naltrexone for Treatment of Multiple Sclerosis (Abstract)
Preclinical and clinical studies into the bioactivity of low-dose naltrexone (LDN) for oncotherapy (Abstract)
Effects of low-dose naltrexone on quality of life in high-grade glioma patients... (Abstract)
Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project (Abstract)
Opiate Antagonists for Chronic Pain... (Abstract)
Diabetic Peripheral Neuropathy: Emerging Treatments of Neuropathic Pain and Novel Diagnostic Methods
Efficacy of Low Dose Naltrexone in Psoriasis (Abstract)
Improvement of Hailey-Hailey disease with low-dose naltrexone (Abstract)
Research on low dosage naltrexone (Abstract)
The effects of naltrexone in autistic children: report of two cases (Abstract)
Double-blinded placebo-controlled cross-over pilot trial of naltrexone to treat Gulf War Illness (Abstract)
Treating Lupus Naturally
The Use of Naltrexone in Dermatology. Current Evidence and Future Directions (Abstract)
Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis (Abstract)
The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis... (Abstract)
Updates on the Treatment of Erythrodermic Psoriasis (Abstract)
Nematode filarial Worms in cerebrospinal fluid of a Multiple Sclerosis Patient at Autopsy (Poster)
Low-dose naltrexone for treatment of burning mouth syndrome (Abstract)
The Utilization of Low Dose Naltrexone for Chronic Pain (Abstract)
Low-Dose Naltrexone for Severe Fibromyalgia Syndrome: A Report of a Case With Two-Year Follow-Up
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination... (Abstract)
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes (Abstract)
Severe pruritus of cholestasis in disseminated cancer... (Abstract)
Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study (Abstract)
Alteration of prescription-only drug utilization by low dose naltrexone users with hypothyroidism... (Abstract)
Improvement in Hailey-Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report (Abstract)
Inexpensive Compounding of Low-Dose Naltrexone With Orange Juice (Abstract)
Mast cell activation and autism (Abstract)
Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease... (Abstract)
Extended-release naltrexone for youth with opioid use disorder (Abstract)
Recovery from Chronic Demyelination by Thyroid Hormone Therapy... (Abstract)
Ultra-low dose naloxone upregulates interleukin-10 expression and... (Abstract)
Low-Dose Naltrexone Use in Postural Orthostatic Tachycardia Syndrome... (Abstract)
Resolution of treatment-refractory depression with naltrexone augmentation of paroxetine - a case report (Abstract)
Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells (Abstract)
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis (Abstract)
The effects of chronic naltrexone treatment in young autistic children... (Abstract)
Potential drug interaction with opioid agonist in the setting of chronic low-dose opioid antagonist use (Abstract)
Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone... (Abstract)
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth... (Abstract)
The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation... (Abstract)
Fibromyalgia, autism, and opioid addiction as natural and induced disorders of ... (Abstract)
Metabolic treatment of cancer: intermediate results of a prospective case series (Abstract)
Psychopharmacologic Therapies for Irritable Bowel Syndrome (Abstract)
Lyme borreliosis and multiple sclerosis: any connection? A seroepidemic study (Abstract)