Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Herpes simplex virus
Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease... (Abstract)
Low dose naltrexone for induction of remission in Crohn's disease (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol ... (Abstract)
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report (Abstract)
Naltrexone at low doses (LDN) and its relevance to cancer therapy (Abstract)
The role of immune modulation and anti-inflammatory agents in the management of prostate cancer... (Abstract)
Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery ... (Abstract)
Efficacy of Low Dose Naltrexone in Psoriasis (Abstract)
Improvement of Hailey-Hailey disease with low-dose naltrexone (Abstract)
Research on low dosage naltrexone (Abstract)
The effects of naltrexone in autistic children: report of two cases (Abstract)
Chapter 8 Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis (Abstract)
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain (Abstract)
Low Dose Naltrexone in Dermatology (Abstract)
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients (Abstract)
ALSUntangled No. 8: Low dose naltrexone for ALS (Abstract)
Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice (Abstract)
Central nervous system infectious diseases mimicking multiple sclerosis:... (Abstract)
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone (Abstract)
Low-Dose Naltrexone (LDN) for Chronic Pain at a Single Institution: A Case Series (Abstract)
Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination... (Abstract)
Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes (Abstract)
Severe pruritus of cholestasis in disseminated cancer... (Abstract)
Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study (Abstract)
Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease? (Abstract)
A Retrospective Review of Patients Prescribed Low Dose Naltrexone for Chronic Pain (Abstract)
The Use of Low-Dose Naltrexone for Chronic Pain (Abstract)
Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)
Complex Regional Pain Syndrome: A Comprehensive Review (Abstract)
What Could Be a Primary Cause of Multiple Sclerosis: Is It an Autoimmunity Triggered by Chronic Protozoan Infection? (Abstract)
Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia... (Abstract)
Ocular surface itch and pain: key differences and similarities between the two sensations (Abstract)
Resolution of treatment-refractory depression with naltrexone augmentation of paroxetine - a case report (Abstract)
Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells (Abstract)
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis (Abstract)
The effects of chronic naltrexone treatment in young autistic children... (Abstract)
In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain... (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Corticotropin-releasing hormone and the blood-brain-barrier (Abstract)
Ultra-low dose naloxone restores the antinocicepitve effect of morphine in... (Abstract)
Combination therapy: A New Tool for the Management of Obesity (News)
Low-Dose Naltrexone Gaining Recognition as Chronic Pain Treatment
Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis (Abstract)
Enkephalin Therapy Improves Relapsing-Remitting Multiple Sclerosis (Abstract)
Oral naltrexone to enhance analgesia in patients receiving continuous intrathecal morphine for chronic pain... (Abstract)
Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form (Abstract)
Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
Opioid receptor system contributes to the acute and sustained antidepressant-like effects... (Abstract)
Chronic Bacterial and Viral Infections in Neurodegenerative and Neurobehavioral Diseases (Abstract)
A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers-Danlos Syndrome (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia... (Abstract)
Low‐dose naltrexone for the treatment of fibromyalgia... (Abstract)
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis... (Abstract)
Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children (Abstract)
Pilot study into low dose naltrexone (LDN) and NAD+ for treatment of patients with post-COVID-19 syndrome (Study)
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats (Abstract)
A novel glial cell inhibitor, low dose naltrexone, reduces pain and depression... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
LDN Protects Bone Property Deterioration at Different Hierarchical Levels in T2DM Mice Bone (Abstract)
Chronic central nervous system involvement in Lyme borreliosis (Abstract)
Off-label pharmacological treatment for neuropathic pain... (Abstract)
Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic (Abstract)
Off-label, Low-Dose Naltrexone for Refractory Chronic Low Back Pain (Abstract)
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice... (Abstract)
Naltrexone in autistic children: behavioral symptoms and attentional learning (Abstract)
Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Abstract)
Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy (Abstract)
Hailey-Hailey disease treated successfully with naltrexone and magnesium (Abstract)
Successful treatment of dermatomyositis with low-dose naltrexone (Abstract)
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma (Abstract)
Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease... (Abstract)
A Narrative Review of Therapies for Scalp Dermatomyositis (Abstract) (LDN, low dose naltrexone)
The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice (Abstract)
Long COVID: major findings, mechanisms and recommendations (Abstract)
Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study (Abstract)
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone (Abstract)
Proceedings #47: Low Dose Naltrexone: A Viable Alternative for Long Term Chronic Pain? (Abstract)
Effect of naltrexone upon self-injurious behavior, learning and activity: a case study (Abstract)
Hailey-Hailey Disease with Superimposed Eczema Herpeticum... (Abstract)
Low-Dose Naltrexone in newly diagnosed high-grade glioma... (Abstract)
Opioid antagonists as potential therapeutics for ischemic stroke (Abstract)
Low-dose naltrexone: A possible safe effective treatment for autoimmune disease and cancer (Abstract)
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma... (Abstract)
Low-Dose Naltrexone (LDN) Treatment for Crohn's Disease (CD)... (Abstract)
Low-Dose Naltrexone Co-Treatment in the Prevention of Opioid-Induced Hyperalgesia (Abstract)
Topical Therapeutic Options in Corneal Neuropathic Pain (Abstract)
Diagnosis and Management of a Hypersensitivity Reaction to Titanium-Containing Surgical Clips... (Abstract)