Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

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Below you will find a list of published papers, which we will update as they become available.

Resolution of treatment-refractory depression with naltrexone augmentation of paroxetine - a case report (Abstract)
Low Dose Naltrexone Reduces In Vitro Endoplasmic Reticulum Stress and Stimulates Wound Healing in Intestinal Epithelial Cells (Abstract)
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis (Abstract)
The effects of chronic naltrexone treatment in young autistic children... (Abstract)
In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain... (Abstract)
Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer (Abstract)
Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis.,, (Abstract)
Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking... (Abstract)
Low Dose Naltrexone in the Treatment of Crohn's Disease: A Case Series (Abstract)
Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome... (Abstract)
Low-Dose Naltrexone Gaining Recognition as Chronic Pain Treatment
Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis (Abstract)
Enkephalin Therapy Improves Relapsing-Remitting Multiple Sclerosis (Abstract)
Oral naltrexone to enhance analgesia in patients receiving continuous intrathecal morphine for chronic pain... (Abstract)
Treatment of a serious autistic disorder in a child with Naltrexone in an oral suspension form (Abstract)
Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants (Abstract)
Dose Escalation of Naltrexone to Reduce Stress Responses Associated With Opioid Antagonist Induction... (Abstract)
Clinical utility of the cold pressor test: evaluation of pain patients... (Abstract)
Co-Administration of Low-Dose Naltrexone and Bupropion Reduces Alcohol Drinking... (Abstract)
Long-term remission of adenoid cystic tongue carcinoma with low dose naltrexone... (Abstract)
Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia... (Abstract)
Low‐dose naltrexone for the treatment of fibromyalgia... (Abstract)
Low-dose naltrexone inhibits colorectal cancer progression and promotes apoptosis... (Abstract)
Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children (Abstract)
Pilot study into low dose naltrexone (LDN) and NAD+ for treatment of patients with post-COVID-19 syndrome (Study)
Evaluation of therapeutic effect of low dose naltrexone in experimentally-induced Crohn's disease in rats (Abstract)
Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders (Abstract)
Intermittent blockade of OGFr and treatment of autoimmune disorders (Abstract)
Combination therapy for obesity (Abstract)
Low dose naltrexone in therapy resistant IBD, a case series (Abstract)
Low Dose Naltrexone in Endometrial Intraepithelial Neoplasia (Abstract)
Survey-reported medication changes among older adults during the SARS-CoV-2 (COVID-19) pandemic (Abstract)
Off-label, Low-Dose Naltrexone for Refractory Chronic Low Back Pain (Abstract)
Anticonvulsant Effects of Thalidomide on Pentylenetetrazole-Induced Seizure in Mice... (Abstract)
Naltrexone in autistic children: behavioral symptoms and attentional learning (Abstract)
Low-dose naltrexone in the treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (Abstract)
A novel glial cell inhibitor, low dose naltrexone, reduces pain and depression... (Abstract)
Anxiolytics, adrenergic agents, and naltrexone (Abstract)
Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Condition... (Abstract)
Low dose naltrexone in multiple sclerosis: Effects on medication use... (Abstract)
Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment (Abstract)
Immunometabolic Modulatory Role of Naltrexone in BV-2 Microglia Cells (Abstract)
Intranasal Low-Dose Naltrexone Against Opioid Side Effects: A Preclinical Study (Abstract)
Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone (Abstract)
Proceedings #47: Low Dose Naltrexone: A Viable Alternative for Long Term Chronic Pain? (Abstract)
Effect of naltrexone upon self-injurious behavior, learning and activity: a case study (Abstract)
Hailey-Hailey Disease with Superimposed Eczema Herpeticum... (Abstract)
Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy (Abstract)
Long-term effects of naltrexone on self-injurious behavior (Abstract)
Treatment of psoriasis vulgaris using low-dose naltrexone (Abstract)
Low-dose naltrexone: a novel treatment for Hailey-Hailey disease (Abstract)
Immunological changes in IBD patients responding to low-dose naltrexone treatment (Abstract)
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome... (Abstract)
Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management (Abstract)
Naltrexone could alleviate depression symptoms in patients who relapsed while taking antidepressants (Abstract)
Identfication and Treatment of New Inflammatory Triggers for Complex Regional Pain Syndrome... (Abstract)
Oxytrex: an oxycodone and ultra-low-dose naltrexone formulation (Abstract)
Problem drinking and low-dose naltrexone-assisted opioid detoxification (Abstract)
Low-Dose Naltrexone in newly diagnosed high-grade glioma... (Abstract)
Early outcomes following low dose naltrexone enhancement of opioid detoxification (Abstract)
The Long Term Suppression of Experimental Autoimmune Encephalomyelitis... (Abstract)
Naltrexone modulates growth in infant rats )Abstract)
Impact of Low Dose Naltrexone (LDN) on antiretroviral therapy (ART) treated HIV+ adults... (Abstract)
The Neuropsychoanalytic Approach: Using Neuroscience as the Basic Science of Psychoanalysis (Abstract)
Low-dose Naltrexone Targets the Opioid Growth Factor... (Abstract)
Naltrexone Therapy for Crohn’s Disease and Ulcerative Colitis (Abstract)
Preliminary study of altered skin temperature at body sites associated with self-injurious behavior... (Abstract)
Low-Dose Naltrexone Evaluated for Neuropathic Corneal Pain (Abstract)
Initial Findings of an Open-Label Trial of Low-Dose Naltrexone for Symptomatic Mesenteric Panniculitis (Abstract)
Low-Dose Naltrexone in Diseases' Treatment: Global Review (Abstract)
Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion (Abstract)
Opioid antagonist-induced regulation of organ development (Abstract)
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer ... (Abstract)
MS breakthrough: Cancer drug repairs damaged myelin nerve tissue in human trials first
Does Naltrexone Treatment Lead to Depression?... (Abstract)
Brief report: six months continuation treatment in naltrexone-responsive children with autism... (Abstract)
Sequential analysis of the effects of naltrexone on the environmental mediation of self-injurious behavior (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Endogenous opioid inhibition of proliferation of T and B cell subpopulations... (Abstract)
Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis (Abstract)
Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution ... (Abstract)
Opioid antagonist modulation of murine neuroblastoma... (Abstract)
What Do Primary Care Providers and Nurses Need to Know About Managing Chronic Pain? (Abstract)
Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review (Abstract)
Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships (Abstract)
Targeting the opioid growth factor: opioid growth factor receptor axis for treatment of human ovarian cancer (Abstract)
Self-injurious behavior and the efficacy of naltrexone treatment: a quantitative synthesis (Abstract)
Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis (Abstract)
Naltrexone's Impact on Cancer Progression and Mortality... (Abstract)
Neuropathic Corneal Pain: Approaches for Management (Abstract)
The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia (Abstract)
Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause? (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
The Benefits of Low Dose Naltrexone (Abstract)
Opioid-induced hypogonadism: Pathophysiology, clinical and therapeutics review (Abstract)
Oxycodone combined with opioid receptor antagonists: efficacy and safety (Abstract)
Efficacy and safety of naltrexone use in pediatric patients with autistic disorder (Abstract)
Double-blinded placebo-controlled cross-over pilot trial of naltrexone to treat Gulf War Illness (Abstract)
Treating Lupus Naturally