Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

The effect of low-dose naltrexone on solid Ehrlich carcinoma in mice: The role of OGFr, BCL2, and immune response (Abstract)
Etiological Pathways Toward Autism and Diversities of Treatments... (Abstract)
Reversal of signs and symptoms of a B-Cell lymphoma in a patient using only low-dose naltrexone
Naltrexone and nalmefene attenuate cocaine place preference in male mice (Abstract)
Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics (Abstract)
Is fibromyalgia an endocrine/endorphin deficit disorder?... (Abstract)
Low Dose Naltrexone in Conjunction With the Wahls Protocol to Reduce the Frequency of Chronic Migraines... (Abstract)
Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone (Abstract)
Combination of Naltrexone and Isotretinoin for the Treatment of Darier Disease (Abstract)
Effective Doses of Low-Dose Naltrexone for Chronic Pain – An Observational Study
[Met 5]-enkephalin preserves diffusion metrics in EAE mice (Abstract)
Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex (Abstract)
129 Medication Assisted Treatment Protocol (Abstract)
Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers (Abstract)
Low-dose naltrexone augmentation of nicotine replacement (Abstract)
No Antagonists for an Antagonist: One Pitfall of Chronic Oral Low-Dose Naltrexone (Abstract)
Low-Dose Naltrexone-Induced Remission in Hailey-Hailey Disease Maintained in Remission (Abstract)
Generalized familial benign chronic pemphigus (Hailey-Hailey disease) treated successfully... (Abstract)
Naltrexone modulates tumor response in mice with neuroblastoma (Abstract)
Single cohort study of the effect of Low Dose Naltrexone on the evolution of immunological, virological and clinical... (Abstract)
Darier and Hailey-Hailey disease: update 2021 (Abstract) (LDN, low dose naltrexone)
Repurposing low-dose naltrexone (LDN) for the prevention and treatment of immunothrombosis in COVID-19 (Abstract)
The Safety and Efficacy of Low-Dose Naltrexone in Patients with Fibromyalgia... (Abstract)
Low-Dose Naltrexone for Excoriation Disorder
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study (Abstract)
Low-dose Naltrexone as a Treatment for Chronic Fatigue Syndrome (Abstract)
Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone (Abstract)
Naltrexone in autistic children: a double-blind and placebo-controlled study (Abstract)
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures (Abstract)
Low Dose Naltrexone (LDN): New in the treatment of chronic pain syndromes... (Abstract)
Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents... (Abstract)
Low-dose naltrexone suppresses ovarian cancer... (Abstract)
Naltrexone modulates body and brain development in rats... (Abstract)
Low-Dose Naltrexone for Pruritus in Systemic Sclerosis (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer... (Abstract)
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic: ... (Abstract)
Low-dose naltrexone (LDN): consumption trend in Brazilian capitals... (in Portuguese) (Abstract)
Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia
Naltrexone a potential therapeutic candidate for COVID-19 (Abstract)
Low Dose Naltrexone in the Treatment of HIV Infection (Abstract)
Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes... (Abstract)
Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study (Abstract)
Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function... (Abstract)
Low Dose Naltrexone for Treatment of Multiple Sclerosis... (Abstract)
Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice (Abstract)
Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy (Abstract)
Modulation of human neuroblastoma transplanted into nude mice... (Abstract)
Low-dose naltrexone plays antineoplastic role in cervical cancer progression... (Abstract)
Prurigo excoriée treated with low dose naltrexone (Abstract)
Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn's disease... (Abstract)
Efficacy of Low-Dose Naltrexone and Predictors of Treatment Success or Discontinuation in Fibromyalgia... (Abstract)
German Journal of Veterinary Research Current pharmacotherapeutic properties of low-dose naltrexone therapy in humans and possible therapeutic and prophylactic indications in cats and dogs
Low-dose naltreoxone for the treatment of irritable bowel syndrome: a pilot study (Abstract)
The opioid antagonist naltrexone improves murine inflammatory bowel disease (Abstract)
Naltrexone open trial with a 5-year-old-boy. A social rebound reaction (Abstract)
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of... (Abstract)
Potential antidepressant role of low-dose naltrexone in a rat model of chronic unpredictable mild stress (Abstract)
Low dose naltrexone in refractory neuropathic pain associated with autoimmune transverse myelitis (Abstract)
Sjogren's Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy (Abstract)
Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing... (Abstract)
Low dose naltrexone therapy in multiple sclerosis (Abstract)
Influence of low dose naltrexone on Raman assisted bone quality, skeletal advanced glycation... (Abstract)
In Response Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review" (Abstract)
Reversible Hair Loss in Lichen Planopilaris: Regrowth With Low-Dose Naltrexone and Platelet-Rich Plasma (Abstract)
Low-dose naltrexone in the treatment of fibromyalgia: A systematic review and narrative synthesis (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Low-dose Naltrexone for the treatment of sarcoidosis (Abstract)
The use of Low-Dose Naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain (Abstract)
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects (Abstract)
Low-dose naltrexone effects on plasma chemistries and... (Abstract)
Low Dose Naltrexone for Neuropathic Pain Related to an Electrical Burn Injury: A Case Study (Article)
Press Release: WAYT-less™ by Nu Image Medical® Exceeds All Projections for Q4 2020
Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis (Abstract)
Morphine reduced perceived anger from neutral and implicit emotional expressions (Abstract)
Low-dose naltrexone therapy improves active Crohn's disease (Abstract)
Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: ... (Abstract)
Effect of Low-Dose Naltrexone on Egyptian Children with Intractable Epilepsy: A Case Series Study (Abstract)
The role of immune modulation and anti-inflammatory agents in the management of prostate cancer... (Abstract)
Acute Low Dose Naltrexone Increases β-Endorphin and Promotes Neuronal Recovery ... (Abstract)
A Utilization Review of Patients That Respond to Low-Dose Naltrexone (LDN) for Chronic Pain at a Single Institution
Low-Dose Naltrexone Reverses Facial Mechanical Allodynia in a Rat Model of Trigeminal Neuralgia (Abstract)
Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome (Abstract)
Naltrexone and communication skills in young children with autism (Abstract)
Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS (Abstract)
Disease remission after commencing naltrexone in an atypical case of Crohn’s disease... (Abstract)
A potential anti-inflammatory effect of low-dose naltrexone in fibromyalgia (Abstract)
Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone... (Abstract)
The multifaceted role of astrocytes in regulating myelination (Abstract)
Low-dose naltrexone for treatment of duodenal Crohn's disease in a pediatric patient (Abstract)
Pharmacotherapy of obesity: An update (Abstract)
Study protocol ... examining the add-on efficacy, cost-utility of low-dose naltrexone ... in patients with fibromyalgia (Abstract)
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone (Abstract)
Low-Dose Naltrexone (LDN) for Chronic Pain at a Single Institution: A Case Series (Abstract)
Beyond Antivirals: Alternative Therapies for Long COVID
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease... (Abstract)
Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer (Abstract)