Clinical Trials Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

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Below you will find a list of published papers, which we will update as they become available.

Preclinical and clinical studies into the bioactivity of low-dose naltrexone (LDN) for oncotherapy (Abstract)
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Disease remission after commencing naltrexone in an atypical case of Crohn’s disease... (Abstract)
Low Dose Naltrexone, A Helpful Option to Battle Depression & Anxiety
The Use of Naltrexone in Dermatology. Current Evidence and Future Directions (Abstract)
Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis (Abstract)
The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis... (Abstract)
Updates on the Treatment of Erythrodermic Psoriasis (Abstract)
Abstract #13: Low-Dose Naltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study (Abstract)
Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial (Abstract)
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling (Abstract)
Low dose naltrexone (LDN) enhances maturation of bone marrow dendritic cells (BMDCs) (Abstract)
Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease... (Abstract)
Improvement in Hailey-Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report (Abstract)
Inexpensive Compounding of Low-Dose Naltrexone With Orange Juice (Abstract)
Mast cell activation and autism (Abstract)
Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease... (Abstract)
Extended-release naltrexone for youth with opioid use disorder (Abstract)
Warning - Fake Medications
Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease) (Abstract)
Low-dose Naltrexone Therapy for Psoriasis (Abstract)
Opiate hypothesis in infantile autism? Therapeutic trials with naltrexone (Abstract)
Opioid-immune interactions in autism... (Abstract)
Low-dose naltrexone and opioid consumption: a drug utilization cohort study... (Abstract)
Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone... (Abstract)
Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth... (Abstract)
The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation... (Abstract)
Fibromyalgia, autism, and opioid addiction as natural and induced disorders of ... (Abstract)
Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills? (Abstract)
Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone(Abstract)
Low‐dose naltrexone in Hailey–Hailey disease: the importance of dosing (Abstract)
Naltrexone in autistic children: an acute open dose range tolerance trial (Abstract)
Repurposing Medications—Chicken Manure, Erectile Dysfunction, and Finding the Golden Needle in the Haystack of Absurdity (Abstract)
Functional modulation on macrophage by low dose naltrexone (LDN) (Abstract)
Low-dose naltrexone: a novel adjunctive treatment in symptomatic alopecias? (Abstract)
The uses of naltrexone in dermatologic conditions (Abstract)
Psychoneuroimmunological approach to gastrointestinal related pain IAbstract)
Metabolic treatment of cancer: intermediate results of a prospective case series (Abstract)
Use of low-dose naltrexone in the management of chronic pain conditions: A systematic review (Abstract)
Successful induction of ovulation in normogonadotrophic clomiphene resistant anovulatory women... (Abstract)
The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris... (Abstract)
Prevention and diminished expression of experimental autoimmune encephalomyelitis by low dose naltrexone (LDN) or opioid growth factor (OGF)... (Abstract)
Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization (Abstract)
Low-Dose Naltrexone: A New Therapy Option for Complex Regional Pain Syndrome Type I Patients (Abstract)
Safety and tolerability of ALO-02 (oxycodone hydrochloride and sequestered naltrexone hydrochloride)... (Abstract)
Efficacy of low dose naltrexone for patients that suffer from comorbid depressive illness (Abstract)
Naltrexone Inhibits IL-6 and TNFα Production in Human Immune Cell Subsets... (Abstract)
Apparent efficacy and safety of low dose naltrexone in Australian patients with active Crohn's disease (Abstract)
Abuse Liability, Anti-Nociceptive, and Discriminative Stimulus Properties of IBNtxA (Abstract)
Naltrexone and other potential new pharmacological treatments of autismx (Abstract)
Transition of Patients With Opioid Use Disorder From Buprenorphine to Extended-Release Naltrexone... (Abstract)
Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders (Abstract)
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis (Abstract)
Opioid growth factor and low dose naltrexone impair central nervous system infiltration... (Abstract)
Reversal of signs and symptoms of a B-Cell lymphoma in a patient using only low-dose naltrexone
Naltrexone and nalmefene attenuate cocaine place preference in male mice (Abstract)
Ethical Considerations of Patient-Funded Research for Multiple Sclerosis Therapeutics (Abstract)
Is fibromyalgia an endocrine/endorphin deficit disorder?... (Abstract)
Single cohort study of the effect of Low Dose Naltrexone on the evolution of immunological, virological and clinical... (Abstract)
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia (Abstract)
The Uses of Low-Dose Naltrexone in Clinical Practice (Abstract)
Low Dose Naltrexone: Side Effects and Efficacy in Gastrointestinal Disorders (Abstract)
The long-term survival of a patient with pancreatic cancer with metastases to the liver... (Abstract)
A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence (Abstract)
Effects of low-dose naltrexone on feed intake, growth, endocrine and immune... (Abstract)
Low-Dose Naltrexone-Induced Remission in Hailey-Hailey Disease Maintained in Remission (Abstract)
Generalized familial benign chronic pemphigus (Hailey-Hailey disease) treated successfully... (Abstract)
Naltrexone modulates tumor response in mice with neuroblastoma (Abstract)
Low-Dose Naltrexone for Pruritus in Systemic Sclerosis (Abstract)
Ameliorative response to detoxification, psychotherapy, and medical management in patients maintained on opioids for pain (Abstract)
Naltrexone and Dysphoria: Fact or Myth? (Abstract)
Successful Treatment of Adult-Onset Dermatitis Herpetiformis with Low Dose Naltrexone (Abstract)
Naltrexone plasma levels, clinical response and effect on weight in autistic children (Abstract)
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone (Abstract)
Treatment of clinically isolated syndrome with Low Dose Naltrexone (Abstract)
Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents... (Abstract)
Low-dose naltrexone suppresses ovarian cancer... (Abstract)
Naltrexone modulates body and brain development in rats... (Abstract)
Low-dose naltrexone plays antineoplastic role in cervical cancer progression... (Abstract)
Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits... (Abstract)
Low dose naltrexone in the treatment of fibromyalgia (Abstract)
Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis (Abstract)
Placebo-controlled acute dosage naltrexone study in young autistic children (Abstract)
Variable Response to Naltrexone in Patients With Hailey-Hailey Disease (Abstract)
Duration of opioid receptor blockade determines biotherapeutic response (Abstract)
Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice (Abstract)
Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy (Abstract)
Modulation of human neuroblastoma transplanted into nude mice... (Abstract)
Influence of low dose naltrexone on Raman assisted bone quality, skeletal advanced glycation... (Abstract)
Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review (Abstract)
The Lowdown on Low-Dose Naltrexone (Abstract)
Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis (Abstract)
Effectiveness Study Low-Dose Naltrexone Versus ARV's for HIV+ (Study)
Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder ... (Abstract)
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal (Abstract)
Sjogren's Syndrome: Clinical Benefits of Low-dose Naltrexone Therapy (Abstract)
Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing... (Abstract)