Clinical Trials Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

The LDN Conference 2021: 4th - 6th June 2021

Up to 29 CME Credits Available + Sponsor, Exhibitor and Advertiser Opportunities.  [More Details]

Below you will find a list of published papers, which we will update as they become available.

Tracking the spread of Parkinson’s proteins from gut to brain
Low dose naltrexone in the treatment of dissociative symptoms (Abstract)
Bernard Bihari, MD: Low-Dose Naltrexone for normalizing immune system function (Abstract)
Modulation of the opioid growth factor ([Met(5)]-enkephalin)-opioid growth factor receptor axis... (Abstract)
Naltrexone in young autistic children: replication study and learning measures (Abstract)
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway... (Abstract)
Correction: Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis... (Abstract)
Variable response to low‐dose naltrexone in patients with Darier disease... (Abstract)
Serum [Met 5]-enkephalin levels are reduced in multiple sclerosis and restored by low-dose naltrexone (Abstract)
Effects of systemic opioid receptor ligands on ethanol- and sucrose seeking and drinking ... (Abstract)
Effects of Naloxone and Naltrexone on Locomotor Activity in C57BL/6 and DBA/2 Mice (Abstract)
Low-dose naltrexone therapy in benign chronic pemphigus (Hailey-Hailey disease): A case series (Abstract)
Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules (Abstract)
Effect of transcutaneous electrical stimulation on nociception and edema induced by peripheral serotonin (Abstract)
Pilot Study Into the Use of Metformin and LDN for Patients With COVID-19 (Study)
Naltrexone at low doses upregulates a unique gene expression... (Abstract)
Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy (Abstract)
Low-dose naltrexone for disease prevention and quality of life (Abstract)
Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris (Abstract)
Low-Dose Naltrexone Therapy Improves Active Ulcerative Colitis (Abstract)
[Met 5]-enkephalin preserves diffusion metrics in EAE mice (Abstract)
Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex (Abstract)
129 Medication Assisted Treatment Protocol (Abstract)
Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers (Abstract)
The effect of low-dose naltrexone on solid Ehrlich carcinoma in mice: The role of OGFr, BCL2, and immune response (Abstract)
Etiological Pathways Toward Autism and Diversities of Treatments... (Abstract)
Corrigendum: The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
The effect of naltrexone as a carboplatin chemotherapy-associated drug on the immune response... (Abstract)
Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents ... (Abstract)
Treatment of Complex Regional Pain Syndrome (CRPS) Using Low Dose Naltrexone (LDN) (Abstract)
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study (Abstract)
Low-dose Naltrexone as a Treatment for Chronic Fatigue Syndrome (Abstract)
Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone (Abstract)
Naltrexone in autistic children: a double-blind and placebo-controlled study (Abstract)
Low-dose naltrexone augmentation of nicotine replacement (Abstract)
No Antagonists for an Antagonist: One Pitfall of Chronic Oral Low-Dose Naltrexone (Abstract)
Hailey-Hailey disease treated successfully with naltrexone and magnesium (Abstract)
Successful treatment of dermatomyositis with low-dose naltrexone (Abstract)
Opioid antagonists inhibit the growth of metastatic murine neuroblastoma (Abstract)
Safety and tolerability of Low-Dose Naltrexone therapy in children with moderate to severe Crohn's disease... (Abstract)
Naltrexone a potential therapeutic candidate for COVID-19 (Abstract)
Low Dose Naltrexone in the Treatment of HIV Infection (Abstract)
Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes... (Abstract)
Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study (Abstract)
Ultra-low dose naltrexone potentiates the anticonvulsant effect of low dose morphine on clonic seizures (Abstract)
Low Dose Naltrexone (LDN): New in the treatment of chronic pain syndromes... (Abstract)
Opioid antagonists as potential therapeutics for ischemic stroke (Abstract)
Low-dose naltrexone: A possible safe effective treatment for autoimmune disease and cancer (Abstract)
Duration of opiate receptor blockade determines tumorigenic response in mice with neuroblastoma... (Abstract)
Low-Dose Naltrexone (LDN) Treatment for Crohn's Disease (CD)... (Abstract)
Low-dose naltreoxone for the treatment of irritable bowel syndrome: a pilot study (Abstract)
The opioid antagonist naltrexone improves murine inflammatory bowel disease (Abstract)
Naltrexone open trial with a 5-year-old-boy. A social rebound reaction (Abstract)
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of... (Abstract)
Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function... (Abstract)
Low Dose Naltrexone for Treatment of Multiple Sclerosis... (Abstract)
Enhancing acupuncture by low dose naltrexone (Abstract)
Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer ... (Abstract)
Endogenous opioid systems regulate cell proliferation in the developing rat brain (Abstract)
Inflammatory Leptomeningeal Cytokines Mediate COVID-19 Neurologic Symptoms in Cancer Patients (Abstract)
Low-dose Naltrexone for the treatment of sarcoidosis (Abstract)
The use of Low-Dose Naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain (Abstract)
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects (Abstract)
Low-dose naltrexone effects on plasma chemistries and... (Abstract)
Potential antidepressant role of low-dose naltrexone in a rat model of chronic unpredictable mild stress (Abstract)
Low dose naltrexone in refractory neuropathic pain associated with autoimmune transverse myelitis (Abstract)
Naltrexone for the Treatment of Darier and Hailey-Hailey Diseases (Abstract)
Compounded Low-dose Naltrexone for the Treatment of Guttate Psoriasis... (Abstract)
Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone (Abstract)
The Effects of Low Dose Naltrexone on Opioid Induced Hyperalgesia and Fibromyalgia (Abstract)
Low-Dose Naltrexone Reverses Facial Mechanical Allodynia in a Rat Model of Trigeminal Neuralgia (Abstract)
Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome (Abstract)
Naltrexone and communication skills in young children with autism (Abstract)
Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS (Abstract)
Low Dose Naltrexone for Neuropathic Pain Related to an Electrical Burn Injury: A Case Study (Article)
Press Release: WAYT-less™ by Nu Image Medical® Exceeds All Projections for Q4 2020
Systemic administration of low-dose naltrexone increases bone mass due to... (Abstract)
The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease... (Abstract)
Bee Venom Therapy and Low Dose Naltrexone for Treatment of Multiple Sclerosis (Abstract)
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Disease remission after commencing naltrexone in an atypical case of Crohn’s disease... (Abstract)
Low Dose Naltrexone, A Helpful Option to Battle Depression & Anxiety
The Use of Naltrexone in Dermatology. Current Evidence and Future Directions (Abstract)
Modulation of the OGF-OGFr pathway alters cytokine profiles in experimental autoimmune encephalomyelitis and multiple sclerosis (Abstract)
The effect of low-dose naltrexone on quality of life of patients with multiple sclerosis... (Abstract)
Abstract #13: Low-Dose Naltrexone's Tolerability and Effects in Fatigued Patients with Parkinson's Disease: An Open-Label Study (Abstract)
Outpatient transition to extended-release injectable naltrexone for patients with opioid use disorder: A phase 3 randomized trial (Abstract)
Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling (Abstract)
Low dose naltrexone (LDN) enhances maturation of bone marrow dendritic cells (BMDCs) (Abstract)
Use of low dose naltrexone and change in use of prescription drugs in patients with inflammatory bowel disease... (Abstract)
Improvement in Hailey-Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report (Abstract)
Inexpensive Compounding of Low-Dose Naltrexone With Orange Juice (Abstract)
Mast cell activation and autism (Abstract)
Therapy with the Opioid Antagonist Naltrexone Promotes Mucosal Healing in Active Crohn’s Disease... (Abstract)
Warning - Fake Medications
Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease) (Abstract)
Low-dose Naltrexone Therapy for Psoriasis (Abstract)