Clinical Trial Abstracts

Since the late 1970s there have been many trials and studies carried out on Low Dose Naltrexone, LDN

Below you will find a list of published papers, which we will update as they become available.

Treatment of psoriasis vulgaris using low-dose naltrexone (Abstract)
Low-dose naltrexone: a novel treatment for Hailey-Hailey disease (Abstract)
Immunological changes in IBD patients responding to low-dose naltrexone treatment (Abstract)
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome... (Abstract)
The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice (Abstract)
Long COVID: major findings, mechanisms and recommendations (Abstract)
Low-Dose Naltrexone Improves post-COVID-19 Condition Symptoms
[Met 5]-enkephalin preserves diffusion metrics in EAE mice (Abstract)
Adding ultralow-dose naltrexone to oxycodone enhances and prolongs analgesia: a randomized, controlled trial of Oxytrex (Abstract)
129 Medication Assisted Treatment Protocol (Abstract)
Dissociation of POMC peptides after self-injury predicts responses to centrally acting opiate blockers (Abstract)
In vitro evaluation of Naltrexone HCl 1% Topical Cream in XemaTop™ for psoriasis (Abstract)
Opioid growth factor and low dose naltrexone impair central nervous system infiltration... (Abstract)
Long-term effects of naltrexone on self-injurious behavior (Abstract)
The Long Term Suppression of Experimental Autoimmune Encephalomyelitis... (Abstract)
Naltrexone modulates growth in infant rats )Abstract)
Impact of Low Dose Naltrexone (LDN) on antiretroviral therapy (ART) treated HIV+ adults... (Abstract)
A double-blind, placebo-controlled, randomized trial of PXT3003 for the treatment of Charcot-Marie-Tooth type 1A (Abstract) (LDN, low dose naltrexone)
Topical Therapeutic Options in Corneal Neuropathic Pain (Abstract)
Diagnosis and Management of a Hypersensitivity Reaction to Titanium-Containing Surgical Clips... (Abstract)
Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study (Abstract)
Low-dose Naltrexone as a Treatment for Chronic Fatigue Syndrome (Abstract)
Erythromelalgia in a Patient with Mast Cell Activation Syndrome: Response to Low Dose Naltrexone (Abstract)
Naltrexone in autistic children: a double-blind and placebo-controlled study (Abstract)
A randomised, controlled trial of low dose naltrexone for the treatment of opioid dependence (Abstract)
Effects of low-dose naltrexone on feed intake, growth, endocrine and immune... (Abstract)
Early outcomes following low dose naltrexone enhancement of opioid detoxification (Abstract)
Low Dose Naltrexone and Lung Cancer: A Case Report and Discussion (Abstract)
Opioid antagonist-induced regulation of organ development (Abstract)
The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer ... (Abstract)
Low-dose naltrexone (LDN)—review of therapeutic utilization (Abstract)
Response to: Invasive Treatments for Low Back Disorders and the ACOEM Practice Guidelines (Abstract)
An Update on the Uses of Naltrexone in Clinical Practice (Abstract)
Current pharmacotherapeutic properties of low-dose naltrexone therapy in humans and possible therapeutic and prophylactic indications in cats and dogs
Naltrexone a potential therapeutic candidate for COVID-19 (Abstract)
Low Dose Naltrexone in the Treatment of HIV Infection (Abstract)
Successful treatment of postural orthostatic tachycardia and mast cell activation syndromes... (Abstract)
Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study (Abstract)
Tolerance to the anticonvulsant effect of morphine in mice: blockage by ultra-low dose naltrexone (Abstract)
Treatment of clinically isolated syndrome with Low Dose Naltrexone (Abstract)
Low-Dose Naltrexone in Diseases' Treatment: Global Review (Abstract)
Pharmacokinetic and pharmaceutical properties of a novel buprenorphine/naloxone sublingual tablet for opioid substitution ... (Abstract)
Opioid antagonist modulation of murine neuroblastoma... (Abstract)
What Do Primary Care Providers and Nurses Need to Know About Managing Chronic Pain? (Abstract)
Low-dose naltrexone for the treatment of fibromyalgia: protocol for... (Abstract)
Low-dose naltrexone, an opioid-receptor antagonist, is a broad-spectrum analgesic... (Abstract)
Pilot Study of Low-Dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: ... (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Low-dose naltreoxone for the treatment of irritable bowel syndrome: a pilot study (Abstract)
The opioid antagonist naltrexone improves murine inflammatory bowel disease (Abstract)
Naltrexone open trial with a 5-year-old-boy. A social rebound reaction (Abstract)
Augmentation of spinal morphine analgesia and inhibition of tolerance by low doses of... (Abstract)
Variable Response to Naltrexone in Patients With Hailey-Hailey Disease (Abstract)
Duration of opioid receptor blockade determines biotherapeutic response (Abstract)
Low-dose naltrexone: a unique treatment for amyopathic dermatomyositis (Abstract)
The Use and Utility of Low-dose Naltrexone Capsules for Patients with Fibromyalgia (Abstract)
Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause? (Abstract)
Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System... (Abstract)
Comments on "Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review" (Abstract)
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction? (Abstract)
Low-Dose Naltrexone in Rheumatological Diseases (Abstract)
Potential pathophysiological role of the ion channel TRPM3 in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the therapeutic effect of low-dose naltrexone
Low-dose Naltrexone for the treatment of sarcoidosis (Abstract)
The use of Low-Dose Naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain (Abstract)
Potentiation of buprenorphine antinociception with ultra-low dose naltrexone in healthy subjects (Abstract)
Low-dose naltrexone effects on plasma chemistries and... (Abstract)
Naltrexone and Scopolamine Rapidly Reduce Symptoms of Major Depressive Disorder ... (Abstract)
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal (Abstract)
Neuropathic Corneal Pain: Approaches for Management (Abstract)
Low dose naltrexone for induction of remission in Crohn's disease (Abstract)
Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol ... (Abstract)
Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report (Abstract)
Naltrexone at low doses (LDN) and its relevance to cancer therapy (Abstract)
Treatment-resistant immune thrombocytopenic purpura associated with LDN use in a patient with MS (Abstract)
Long-Term Effects of Low-Dose Naltrexone on Immunomodulatory Properties of ... (Abstract)
Low-Dose Naltrexone Use in Biopsy-Proven Lichen Planus of the Nails
Low-Dose Naltrexone Reverses Facial Mechanical Allodynia in a Rat Model of Trigeminal Neuralgia (Abstract)
Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome (Abstract)
Naltrexone and communication skills in young children with autism (Abstract)
Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS (Abstract)
Chapter 8 Endogenous Opioids in the Etiology and Treatment of Multiple Sclerosis (Abstract)
Herpes simplex virus
Use of low-dose naltrexone in the treatment of severe Hailey-Hailey disease... (Abstract)
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients (Abstract)
ALSUntangled No. 8: Low dose naltrexone for ALS (Abstract)
Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice (Abstract)
Central nervous system infectious diseases mimicking multiple sclerosis:... (Abstract)
Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study (Abstract)
Low Dose Naltrexone's Utility for Non-Cancer Centralized Pain Conditions... (Abstract)
Pseudo-endocrine Disorders: Recognition, Management, and Action
Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells... (Abstract)
Very low dose naltrexone in opioid detoxification: a double-blind, randomized clinical trial of efficacy and safety (Abstract)
Endogenous opioids regulate expression of experimental autoimmune encephalomyelitis... (Abstract)
Acquired immunodeficiency syndrome: molecular biology and its therapeutic intervention (review) (Abstract)
Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease? (Abstract)
Low-dose naltrexone is effective and well-tolerated for modulating symptoms in patients with neuropathic corneal pain (Abstract)
Low Dose Naltrexone in Dermatology (Abstract)
Emerging Unconventional Therapies for Alopecia Areata (Abstract)
Low Dose Naltrexone Treatment of Established Relapsing-Remitting Experimental Autoimmune Encephalomyelitis (Abstract)