Conditions that are helped by Low Dose Naltrexone (LDN)

The conditions that LDN could help with are listed below:

To watch interviews and conference presentations covering a range of conditions click here

  • Autoimmune cardiomyopathy
  • Dressler's syndrome
  • Kawasaki's disease
  • Polyarteritis nodosa
  • Pyoderma gangrenosum
  • Subacute bacterial endocarditis (SBE)

  • Complex Regional Pain Syndrome/RSD
  • Diabetic Neuropathy

  • Alopecia areata
  • Alopecia universalis
  • Amyopathic Dermatomyositis
  • Anti-synthetase syndrome
  • Atopic allergy
  • Atopic dermatitis
  • Autoimmune progesterone dermatitis
  • Autoimmune thrombocytopenic purpura
  • Autoimmune urticaria
  • Bechet’s syndrome
  • Blau syndrome
  • Bullous pemphigoid
  • Cicatricial pemphigoid
  • Cutaneous leukocytoclastic angiitis
  • Darier Disease
  • Dego's disease (thrombotic vasculopathy)
  • Dercum's disease
  • Dermatitis herpetiformis
  • Dermatomyositis
  • Diffuse cutaneous systemic sclerosis
  • Discoid lupus erythematosus
  • Eczema
  • Epidermolysis bullosa acquisita
  • Erythema nodosum
  • Erythmodermic psoriasis
  • Essential mixed cryoglobulinemia
  • Hailey-Hailey Disease
  • Henoch-Schonlein purpura
  • Herpes gestationis
  • Kawasaki's disease
  • Lichen planus
  • Lichen sclerosus
  • Linear IgA disease
  • Majeed syndrome
  • Microscopic polyangiitis
  • Morphea Mucha-Habermann disease
  • Parry Romberg syndrome
  • Pemphigus vulgaris
  • POEMS syndrome
  • Psoriasis
  • Pyoderma gangrenosum
  • Schnitzler syndrome

  • Autoimmune inner ear disease
  • Churg-Strauss syndrome
  • Cogan syndrome
  • Ménière's disease
  • Susac's syndrome

  • Addison's disease
  • Autoimmune polyendocrine syndrome
  • Cushing's syndrome
  • Diabetes mellitus type 1
  • Graves' disease
  • Hashimoto's thyroiditis
  • Hypoglycaemia
  • Hypopituitary or Secondary adrenal insufficiency
  • Hypothalamic Dysfunction
  • Hypothyroidism
  • Ord’s thyroiditis
  • POEMS syndrome
  • Schmidt syndrome
  • Thyroiditis

  • Autoimmune hepatitis
  • Autoimmune enteropathy
  • Autoimmune pancreatitis
  • Celiac disease
  • Churg-Strauss syndrome
  • Crohn’s disease
  • Eosinophilic gastroenteritis
  • Gastritis
  • Gastrointestinal pemphigoid
  • Inflammatory bowel disease
  • Lupoid hepatitis
  • Nonalcoholic steatohepatitis (NASH)
  • Mesenteric Panniculitis
  • POEMS syndrome
  • Polyarteritis nodosa
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis
  • Pyoderma gangrenosum
  • Small intestinal bacterial overgrowth (SIBO)
  • Schnitzler syndrome
  • Ulcerative colitis

  • Agammaglobulinemia
  • Antiphospholipid syndrome
  • Autoimmune aplastic anemia
  • Autoimmune hemolytic anemia
  • Autoimmune lymphoproliferative syndrome
  • Castleman's disease – lymph node hyperplasia
  • Cold agglutinin disease
  • Evan's syndrome
  • Majeed syndrome
  • Paroxysmal nocturnal hemoglobinuria (PNH)
  • Pernicious anaemia
  • Pure red cell aplasia
  • Pyoderma gangrenosum

  • Hepatitis C

  • Common Variable Immunodeficiency
  • Epstein Barr Virus
  • MCAS (mast cell activation syndrome)
  • Pernicious Anemia
  • Vitiligo

  • Complement component 2 deficiency – increase risk of infections
  • HIV
  • Hypogammaglobulinemia – leads to infections
  • Lyme Disease
  • PANDAS (Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections)
  • Sydenham chorea

  • Adenoid Cystic Carcinoma
  • Bladder Cancer
  • Breast Cancer
  • Carcinoid Colon & Rectal Cancer
  • Cholangiocarcinoma
  • Colon Cancer
  • Esophageal carcinoma
  • Glioblastoma
  • Glioma
  • Hepatoblastoma
  • Liver cancer
  • Lung cancer (Non-small cell)
  • Lymphocytic leukemia (chronic)
  • Lymphoma (Hodgkin's and Non-Hodgkin's)
  • Malignant melanoma
  • Multiple myeloma
  • Neuroblastoma
  • Ovarian cancer
  • Pancreatic cancer
  • Parotid carcinoma
  • Prostate cancer (untreated)
  • Renal cell carcinoma
  • Throat cancer
  • Uterine cancer

  • Acute disseminated encephalomyelitis
  • Acute hemorrhagic leukoencephalitis
  • Amyotrophic Lateral Sclerosis
  • Anti-mag IgM peripheral neuropathy
  • Autoimmune peripheral neuropathy
  • Bickerstaff's encephalitis
  • Charcot-Marie-Tooth syndrome
  • Chronic inflammatory demyelinating polyneuropathy
  • Cranial arteritis
  • Guillain-Barré syndrome
  • Hashimoto's encephalitis
  • Idiopathic inflammatory demyelinating diseases
  • Inflammatory demyelinating polyneuopathy
  • Lambert-Eaton myasthenic syndrome
  • Miller-Fisher syndrome
  • Multiple sclerosis (MS)
  • Myalgic encephalomyelitis
  • Myasthenia gravis
  • Neuromyelitis optica
  • Neuromyotonia
  • Opsoclonus myoclonus syndrome
  • PANDAS (Pediatric autoimmune neuropsychiatric disorders associated with Streptococcal infections)
  • Paraneoplastic cerebellar degeneration
  • Parkinson’s disease
  • Parry Romberg syndrome
  • Parsonage-Turner syndrome
  • Perivenous encephalomyelitis
  • POEMS syndrome
  • Polyarteritis nodosa
  • Progressive inflammatory neuropathy
  • Rasmussen's encephalitis
  • Restless leg syndrome
  • Stiff person syndrome
  • Susac's syndrome
  • Sydenham chorea
  • Tolosa-Hunt syndrome
  • Transverse myelitis

  • Autoimmune uveitis
  • Balo disease/Balo concentric sclerosis
  • Blau syndrome
  • Cogan syndrome
  • Kawasaki's disease
  • Miller-Fisher syndrome
  • Neuromyelitis optica
  • Ocular cicatricial pemphigoid
  • Opsoclonus myoclonus syndrome
  • Parry Romberg syndrome
  • Pars planitis
  • POEMS syndrome
  • Scleritis
  • Susac's syndrome
  • Sweet's syndrome
  • Sympathetic ophthalmia
  • Tolosa-Hunt syndrome
  • Vasculitis vitiligo

  • Addison’s disease
  • Autism
  • Celiac disease
  • Crohn’s disease
  • Juvenile dermatomyositis
  • Juvenile idiopathic rheumatoid arthritis
  • Lupus
  • Multiple sclerosis (MS)
  • PANDAS (Pediatric Autoimmune Neuropsychiatric Disease Associated with Strep Infection)
  • Scleroderma
  • Type-1 diabetes
  • Ulcerative colitis

  • Anxiety
  • Depersonalization/Derealization Disorder (but not DID)
  • General Anxiety Disorder (GAD)
  • Obsessive Compulsive Disorder (OCD)
  • Panic Disorder
  • Postpartum Depression
  • Premenstrual Dysphoric Disorder (PMDD)
  • Social Phobia
  • Trichotillomania
  • Depression
  • Dissociative Disorder
  • Post-Traumatic Stress Disorder (PTSD)

  • Anti-synthetase syndrome
  • Asthma Churg-Strauss syndrome
  • Emphysema
  • Fibrosing alveolitis
  • Goodpasture's syndrome
  • Idiopathic pulmonary fibrosis
  • POEMS syndrome
  • Sarcoidosis

  • Anti-GBM/TBM Nephritis
  • Autoimmune renal neuropathy
  • Berger's disease - IgA nephropathy
  • Glomerulonephritis
  • Goodpasture's syndrome
  • IgA nephropathy
  • Interstitial cystitis
  • Microscopic polyangiitis
  • Paroxysmal nocturnal hemoglobinuria (PNH)
  • POEMS syndrome

  • Ankylosing spondylitis
  • Anti-synthetase syndrome
  • Chronic fatigue syndrome (CFS)
  • Chronic recurrent multifocal osteomyelitis
  • Complement component 2 deficiency – increase risk of lupus
  • CREST syndrome
  • Ehlers-Danlos Syndrome
  • Enthesitis-related arthritis
  • Eosinophilic fasciitis
  • Fibrodysplasia ossificans progressive
  • Fibromyalgia
  • Inclusion body myositis
  • Juvenile idiopathic arthritis
  • Juvenile rheumatoid arthritis – Still’s disease
  • Lupus erythematosus
  • Majeed syndrome
  • Mixed connective tissue disease
  • Morphea myositis
  • Palindromic rheumatism
  • Polymyalgia rheumatica
  • Polymyositis
  • Psoriatic arthritis
  • Raynaud phenomenon
  • Reiter's syndrome
  • Relapsing polychondritis
  • Retroperitoneal fibrosis
  • Rheumatoid arthritis
  • Rheumatoid fever
  • Sarcoidosis
  • Schnitzler syndrome
  • Scleroderma
  • Seropositive arthritis
  • Sjögren's syndrome
  • Spondylitis
  • Spondyloarthropathy
  • Undifferentiated connective tissue disease
  • Undifferentiated spondyloarthropathy

  • Sleep Issues

  • Blau syndrome
  • Churg-Strauss syndrome
  • Essential mixed cryoglobulinemia
  • Giant cell arteritis
  • Kawasaki's disease
  • Leukocytoclastic vasculitis
  • Polyarteritis nodosa
  • Takayasu's arteritis
  • Temporal arteritis (also known as "giant cell arteritis")

  • Endometriosis
  • Healthy pregnancy – new concepts
  • Infertility
  • PMS (premenstrual syndrome)
  • Polycystic Ovary Syndrome (PCOS)
  • Recurrent vaginitis
  • Reduced ovarian reserve (Low AMH)
  • Vulvodynia
  • Painful periods (Dysmenorrhea)

  • POTS (postural orthostatic tachycardia)
  • Traumatic brain injury (TBI)