Formulations of LDN

LDN can be in either: Liquid, Capsules, Sublingual, Cream, Topical Lotion, Eye Drops or Tablets.


Oral Liquid formulation at 1mg/1ml is the most commonly used type of LDN. It is taken daily and dosed using a baby oral syringe.

Cost approx. $0.50 per dose.


In the USA, capsules or tablets in a variety of strengths are available from compounding pharmacies, but it is recommended that these be purchased only from compounders who have a significant level of experience formulating LDN.

Prices tend to range from $0.50-1.50 per dose.

Sublingual Drops

Sublingual drops are designed for patients with problems taking medications orally, or for people who want to guarantee the fastest delivery of the drug into their bloodstream. A number of drops are placed under the tongue from a dropper bottle and dose is increased and decreased by the number of drops taken.

Cost about $1 a dose.

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Cream & Topical Lotion

LDN Cream is most typically available in 0.5mg/ml and is available for application to the skin. This is helpful for children, or for patients allergic to colorings – flavorings or any excipients that may be found in other forms of LDN. It may be more expensive than oral forms.

Eye Drops

The most common ophthalmic naltrexone dose is 0.2% and used for dry eye.


Tables are available from several compounding pharmacies in different strength forms.


Can be made into any dosage and can be split into four. They dissolve under the tongue in one to two minutes. The benefits are comparable to those of sublingual drops.

Nasal Sprays

Can be compounded for acute immune support or as a preferred delivery system for regular use.