Opioid Antagonists - Traumatic Brain Injury

Ulrich Lanius Ph.D. & Galyn Forster M.A.

Clinical Abstract

Background:  
Traumatic brain injury (TBI) is a major global cause of morbidity and long‑term disability. Experimental and clinical observations suggest that opioid antagonists—including naloxone, naltrexone, and nalmefene—may mitigate secondary injury processes and enhance neurological recovery following TBI.

Neuroprotective effects of naltrexone in a mouse model of post-traumatic seizures
Saul Rodriguez et al. Nature.

12th June 2024

https://www.nature.com/articles/s41598-024-63942-8

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