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A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with fibromyalgia

19 April 2023

Low-Dose Naltrexone in Rheumatological Diseases

Mediterr J Rheumatol
31 March 2023

Background: Naltrexone has been approved for alcohol and opioid abuse by the FDA. At low-dose naltrexone (LDN) has been used in several diseases including chronic pain and autoimmune conditions, including rheumatic disorders.

Pilot Study of Low-Dose Naltrexone for the Treatment of Chronic Pain Due to Arthritis: A Randomized, Double-blind, Placebo-Controlled, Crossover Clinical Trial

Clin Ther
10 April 2023

Low-dose naltrexone in the treatment of fibromyalgia: A systematic review and narrative synthesis

Aust J Gen Pract
April 2023

Method: A systematic literature search was conducted using the key words 'naltrexone', 'fibromyalgia', 'fibrositis', 'chronic pain' and 'neurogenic inflammation'.

Efficacy of Low-Dose Naltrexone and Predictors of Treatment Success or Discontinuation in Fibromyalgia and Other Chronic Pain Conditions: A Fourteen-Year, Enterprise-Wide Retrospective Analysis

As revised 23 March 2023

An Update on the Uses of Naltrexone in Clinical Practice

Natural Medicine Journal
01 August 2022


Deena - Canada: Update on her UCTD (Undifferentiated Connective Tissue Disease), Chronic HSV2/Shingles, Chronic Pain, IBS, Histamine Intolerance, Vestibular Migraine, and Insomnia (LDN; low dose naltrexone)



Marilyn - US: RA Pain (LDN; low dose naltrexone)