Journal of Pain Research, Volume 18

Authors: Hannah Aalto, Sara Paul & Virginia McEwen

Published 10 December 2025 Volume 2025:18 Pages 6637—6649

https://www.dovepress.com/real-world-effectiveness-and-tolerability-of-low-dose-naltrexone-to-tr-peer-reviewed-fulltext-article-JPR

Evaluation of Low-Dose Naltrexone for Chronic Pain Management
February 2025 Journal of Pain & Palliative Care Pharmacotherapy 

Alexa Spargo, Lauren Gonser & Brittany Faley

https://www.researchgate.net/publication/388679440_Evaluation_of_Low-Dose_Naltrexone_for_Chronic_Pain_Management

Abstract

Co-administration of low-dose-Naltrexone and Carbamazepine remarkedly ameliorate allodynia and cognitive deficit in a rat model of trigeminal neuralgia

Yeganeh Naderi, Monavareh Soti, Masoud Soltani, Yasaman Naderi, Kristi A. Kohlmeier & Mohammad Shabani

Scientific Reports volume 15, Article number: 31335 (26th August 2025)

https://www.nature.com/articles/s41598-025-14820-4

Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance
By Hoau-yan Wang

2009, Opiate Receptors and Antagonists

https://www.academia.edu/18459676/Ultra_Low_Dose_Opioid_Antagonists_Enhance_Opioid_Analgesia_and_Reduce_Tolerance?email_work_card=view-paper

Mark's Chronic Pain and LDN Journey

Low-Dose Naltrexone for Managing Pain and Autonomic Symptoms in Patients With Dysautonomia

Zapata N, Georgiadi E, Cantrell C, et al. (June 22, 2025)

Cureus 17(6): e86538. doi:10.7759/cureus.86538

Breakthrough book spotlights the life-changing potential of low dose naltrexone (LDN) for chronic pain and complex conditions

The Phoenix Newspaper | Health and Wellbeing
8th June 2025

With millions suffering silently from chronic pain and complex conditions, The LDN Book 4: Case Studies in Chronic Pain (LDN Research Trust) is offering timely and life-changing insights into one of medicine's best-kept secrets — low dose naltrexone (LDN).

Commentary: Article May 12, 2025
 

Can Low-Dose Naltrexone Fill the Gaps in Palliative Pain Management?

Author(s):Emma Murter, PharmD, MPH, Madison N. Irwin, PharmD, BCPS

https://www.pharmacytimes.com/view/can-low-dose-naltrexone-fill-the-gaps-in-palliative-pain-management-

Low-Dose Naltrexone in Pain Management and Inflammatory Disorders

Nature Research Intelligence

https://www.nature.com/research-intelligence/low-dose-naltrexone-in-pain-management-and-inflammatory-disorders

November 7, 2024
By Lauren Massaro

https://www.drugtopics.com/view/q-a-pharmacists-champion-nonopioid-pain-management-strategies

Melissa Durham, PharmD, MACM, reveals how pharmacists are uniquely positioned to counsel patients on nonopioid pain management.