How Chronic Pain Can Lead to Autoimmunity Problems

Pain News Network
08 July 2021
https://www.painnewsnetwork.org/stories/2021/7/8/how-chronic-pain-can-lead-to-autoimmunity

Complex Regional Pain Syndrome: A Comprehensive Review 

Pain Ther
24 June 2021
https://pubmed.ncbi.nlm.nih.gov/34165690/

Low-Dose Naltrexone Use for Patients with Chronic Regional Pain Syndrome: A Systematic Literature Review

Pain Physician
July 2021
https://pubmed.ncbi.nlm.nih.gov/34213865/

Background: Complex regional pain syndrome is a rare, neuropathic disorder that affects fewer than 200,000 individuals in the United States annually. Current treatments often focus on pain management and fall short of relieving symptoms of pain and dystonia in patients.

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice

CNS Neurosci Ther
21 May 2021
https://pubmed.ncbi.nlm.nih.gov/34018697/

Preclinical and clinical studies into the bioactivity of low-dose naltrexone (LDN) for oncotherapy

Int Immunopharmacol
11 May 2021
https://pubmed.ncbi.nlm.nih.gov/33989971/

Utilization of Low-Dose Naltrexone for Burning Mouth Syndrome: A Case Report

A A Pract
17 May 2021
https://pubmed.ncbi.nlm.nih.gov/33999864/

Efficacy and safety of low-dose naltrexone in painful diabetic neuropathy: A randomized, double-blind, active-control, crossover clinical trial

J Diabetes
20 May 2021
https://pubmed.ncbi.nlm.nih.gov/34014028/

Reported Benefits of Low-Dose Naltrexone Appear to Be Independent of the Endogenous Opioid System Involving Proopiomelanocortin Neurons and Beta-Endorphin

eNeuro
24 May 2021
https://www.eneuro.org/content/early/2021/05/21/ENEURO.0087-21.2021