Recalcitrant Hailey-Hailey Disease Successfully Treated with Low-dose Naltrexone

J Clin Aesthet Dermatol
13 November 2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716739/

Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease)

JAMA Dermatol
01 October 2017
https://pubmed.ncbi.nlm.nih.gov/28768314/

Vulvar Hailey-Hailey disease treated with low-dose naltrexone: case report and literature review

Sarcoidosis Vasc Diffuse Lung Dis
10 Aug 2020
https://pubmed.ncbi.nlm.nih.gov/32776297/

Purpose: To report a case of vulvar familial benign pemphigus, or Hailey-Hailey disease, treated successfully with low-dose naltrexone and to review the current literature.

May from Holland used LDN for Hailey-Hailey Disease (Low dose naltrexone) from LDN Research Trust on Vimeo.

Jill Cottel, MD - Treating the Zebras in Primary Care (2017 Conference) (LDN, low dose naltrexone)

In this presentation Dr Cottel shares case studies of patients:

36 year old woman with Ehlers-Danlos Syndrome. This lady was started on Low Dose Naltrexone (LDN) at 1.5mg, increased to 3 mg and found she lost her earlier improvement but on going down to a much lower dose she improved significantly. 

Dickson Chemist developed a new formulation of LDN which will hopefully improve the outcomes for patients. This new formulation is a more concentrated liquid in the form of drops which are administered under the tongue and absorbed directly from the mucosal lining of the mouth. This sublingual route produces a more rapid absorption bypassing the liver and digestive tract. There are several potential advantages to this, the drug may be more effective and will not be affected by the presence of food stuffs or the hostile environment of the gut.