A potential anti-inflammatory effect of low-dose naltrexone in fibromyalgia

J Pain
01 April 2015
https://www.jpain.org/article/S1526-5900(15)00362-4/abstract

In patients with fibromyalgia, is low-dose naltrexone effective in alleviating pain, and does it decrease use of oral opioids?

Evidence-Based Practice
June 2017
https://journals.lww.com/ebp/Abstract/2017/06000/In_patients_with_fibromyalgia,_is_low_dose.13.aspx

Could Low-Dose Naltrexone be an Effective Treatment for Hailey-Hailey Disease?

Integ Biomed Sci
19 July 2016
https://www.gratisoa.org/journals/index.php/MML/article/view/1293/957

Low-Dose Naltrexone in the Treatment of Fibromyalgia: A Retrospective Analysis

Curr Rheumatol Rev
2018
https://pubmed.ncbi.nlm.nih.gov/28325149/

Background: Fibromyalgia is a chronic pain disorder characterized by diffuse musculoskeletal pain, fatigue, sleep disturbance and cognitive impairment.

Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization

Medical Sciences
21 September 2018
https://pdfs.semanticscholar.org/c495/7df14b181c4ae963a80fdeaf38c5cbb1a9e3.pdf?_ga=2.217655315.460139797.1583212532-762170649.1583212532

Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study

Pain Med
May-June 2009
https://pubmed.ncbi.nlm.nih.gov/19453963/

Objective: Fibromyalgia is a chronic pain disorder that is characterized by diffuse musculoskeletal pain and sensitivity to mechanical stimulation. In this pilot clinical trial, we tested the effectiveness of low-dose naltrexone in treating the symptoms of fibromyalgia.

Naltrexone Hydrochloride 1.5-mg and 4.5-mg Capsules

US Pharm
19 March 2020
https://www.uspharmacist.com/article/naltrexone-hydrochloride-15mg-and-45mg-capsules

Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia

Biomedicines
18 April 2017
https://pubmed.ncbi.nlm.nih.gov/28536359/

Pharmacology Update: Low-Dose Naltrexone as a Possible Nonopioid Modality for Some Chronic, Nonmalignant Pain Syndromes

Am J Hosp Palliat Care
October 2019
https://pubmed.ncbi.nlm.nih.gov/30917675/

Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships

Pain Med
01 October 2020
https://pubmed.ncbi.nlm.nih.gov/32068870/

Objective: This study explores dose-response relationships when treating fibromyalgia with low-dose naltrexone.

Design: A single-blinded clinical trial was carried out using the "up-and-down" method.