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Are there any OTC medications or supplements that increase the effectiveness of Low Dose Naltrexone (LDN) for pain relief?
Nothing you can buy over the counter, in the way of medicines or pharmacy medicines, work any better or any less well because you're taking LDN. Tylenol, Ibuprofen, Naproxen, are not affected by LDN and still do their job as well as they normally would.
We have talked about cannabidiol, CBD, and we've also talked earlier on about endocannabinoids and those like PEAS and similar supplements. There are so many supplements that can potentially help. It would be very much a case of having to ask a specific question or having a consultation with an expert before proceeding, but nothing specifically synergizes with LDN directly.
There are a couple of prescribed medications that do, but for the purpose of this question, the answer is generally no.