Low Dose Naltrexone (LDN) can be taken twice a day after the bedtime or once a day dose has been established. Twice a day dosing is helpful for depression and pain control especially with situations like fibromyalgia (FM).
The two doses are generally 12 hours apart, morning and bedtime. We have seen a lot of success with autoimmune issues, fibromyalgia and pain control.
Most disease states do not need twice a day dosing.