Can LDN affect heart rate or palpitations?

Can Low Dose Naltrexone (LDN) affect heart rate or palpitations?

Though I have seen a few patients experience palpitations early on in treatment with Low Dose Naltrexone (LDN), it is often transient, and remedied by lowering the dose and taking a very slow dose escalation. I have never found it to be cardiotoxic. In fact, many patients with arrhythmias report improvement in physical symptoms, and clinically, we will note that on examination as well. Of course, having a thorough physical exam and cardiovascular work up is warranted to understand the root of the problem.

Good communication between patient and provider is key for success and safety.