While I don’t know which disease process you are referring to, the short answer is yes. This is one of the reasons that we taper up over a period of weeks, in order to decrease side effects. However, side effects are usually mild, with the most significant side effect being difficulty sleeping. Side effects typically wear off in a matter of 1-4 weeks. As stated multiple times elsewhere, if you are being treated for Hashimoto’s thyroiditis, your thyroid function needs to be monitored closely for potential adjustment of thyroid medications.