Can Low Dose Naltrexone (LDN) be used for Dupuytren' Contracture?
Can Low Dose Naltrexone (LDN) be used for Dupuytrens' Contracture? Dupuytrens Contracture is a contracture that is usually in the Palmer surface where the fingers can change their angle and that's usually because there's been some narrowing and some scar tissue somewhere in the Palmer surface because of what's going on with the ligaments. Yes, it can be used for that. Is it super successful? It really depends on the individual and it depends on where they're at in their contracture. So at what angle are the fingers? Have they had it for decades or is this something that's just fairly recent? Low Dose Naltrexone in my professional opinion can be used relatively safely. It's used in combination with other medications as well.
Usually the resolution of that contracture is the surgical route. It is not something that is going to resolve just with oral medications. They certainly could help. It can help reduce the inflammation but usually that ligature has shortened for whatever reason, whether it's due to a virus, whether it's due to lack of nutrient status, whether it's an injury. Whatever the source for that Low Dose Naltrexone can be used and it can also be around the time of surgery. The onset of this case was about six months ago. No angle changed, just thickening of the tendons. Surgery has a high reoccurrence rate. That is true.
For that situation, because it's a fairly recent onset, I would recommend, in my professional opinion, starting a Low Dose Naltrexone oral regimen, starting low 0.5 milligram maybe and then slowly increase every seven days. Get up to anywhere between three and four and a half milligram. Perhaps try that for anywhere from four to six months and see what happens. You still may end up going the surgical route but you've got nothing to lose in my professional opinion. I don't see where it would be harmful or I don't see where it would interact with any of the other processes. It's certainly going to help reduce the inflammation and in doing that I think you're going to see better response, perhaps less fullness, less irritation, less pain if you're associated with that and maybe better movement.