Can Low Dose Naltrexone (LDN) block mast cells and stop the release of histamine?

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Leonard Weinstock, MD
Dr Leonard Weinstock
Specialists in Gastroenterology

Can Low Dose Naltrexone (LDN) block mast cells and stop the release of histamine? There are no studies but my theory is that LDN decreases T-cell activity and T-cells definitely activate mast cells. In addition of antibodies also can activate mast cells and LDN reduces B-cell activity and hence could reduce antibody stimulated mast cell activity.