Can Low Dose Naltrexone (LDN) work for Ehlers-Danlos Syndrome?

Dr Norman Marcus, Pain Specialist
Pain Specialist Dr. Norman Marcus

Can Low Dose Naltrexone (LDN) work for Ehlers-Danlos Syndrome?

Well, what does that mean? If you have the  genetic condition of Ehlers-Danlos syndrome and one of the subtypes you most likely will have pain and fatigue because those are the most common presentations in terms of symptoms. And  if you have pain you are very likely to have muscle pain and we did a study that was presented at the role meeting the Ehlers-Danlos Society Consortium this past September showing that there was a much greater incidence of muscle pain in patients who have Ehlers-Danlos syndrome than in patients who do not have Ehlers-Danlos syndrome. And we also showed that there was a 5.7 times increase in the incidence of Mast Cell Activation Syndrome in patients with Ehlers-Danlos syndrome versus those who do not have Ehlers Danlos syndrome. So as a generic answer can it be good for patients with Ehlers-Danlos.  Yes, a third of my practices are Ehlers-Danlos syndrome.