Can you take Low Dose Naltrexone (LDN) with alcohol or PEA?

LDN Specialist Pharmacist Stephen Dickson
Pharmacist Stephen Dickson

Can you take Low Dose Naltrexone (LDN) with alcohol or PEA? Can you take LDN alongside tinctures which also have alcohol in them? Is it also okay to take PEA?

So we do get asked this quite a lot, because naltrexone is used in full dose to help with alcoholism or reducing the drinking of alcohol. So it used to be called the Sinclair method, and the idea was taking a full dose of naltrexone while you are still drinking means that you gradually, because it blocks all of the happiness and the ability to release endorphins, then you disassociate the act of drinking alcohol with any pleasure, because you're blocking the pleasure with Low Dose Naltrexone.

Now, that doesn't happen with Low Dose Naltrexone, so you're not blocking the receptors for long enough and you're not causing enough of an impact for there to be any concern with that altogether. So absolutely fine. If you want to take LDN on the same day as tinctures, then that's absolutely fine. Is it also a case that takes PEA and the answer is yes, but we would suggest probably taking it a separate, different time of day. PEA is an endocannabinoid, it's called Tamaston ethanolide, and it works in a very similar way to CBD or marijuana to help reduce pain. Quite a number of papers on it, it's not licensed in the UK but we do have a number of patients on it. Most of them are animals, though, interestingly, dogs and cats, so it's interesting, but yet PEA is certainly something that we see more of, but not absorbed very well orally. So if you are taking PEA, I would look to try and get a sublingual preparation or something that is liposomal or encapsulated.