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Could 3.5 MG of Low Dose Naltrexone (LDN) be the Sweet Spot?
A patient who's using LDN for GI issues and interstitial cystitis got a significant improvement at the 4.5 mg dose, but, developed some bloating and issues with production she said. I'm reducing her to 3.5 mgs and she's feeling better, but I wasn't sure if this is always also seen in other patients.
So yes, the sweet spot, as people have sort of nicknamed on the internet, can be anywhere from 3 to 4.5 mg or a bit higher or a bit lower for some people because everybody's different.
So, while getting to 4.5 mg is the aim for most prescribers to begin with, there will be a minority of your patients who cannot get to 4.5 mgs no matter how slowly you do it, or when they get to 4.5 mg they feel side effects that just won't go away. So,dropping the dose at that point is perfectly reasonable and going back to 3.5 mg is well within the therapeutic range.