Could MCAS have a role in the development of Parkinson's disease after years of migraines, IBS and allergic asthma?

Could MCAS have a role in the development of Parkinson's disease after years of migraines, IBS and allergic asthma?

Well, we do know, and this is in some articles, if you just Google basically that mast cells do, they lead to neurodegenerative conditions.

So I think that's the best answer I could give it to, you know, look at Parkinson's and then MA cells and see that article that looks at MS and as one additional disease that can relate to the activation and chemicals from MAST cells. Yeah, I'll take that one step further and say that, I saw one of the questions that came in is related to this in a way, mast cells can interact with different cells in the nervous system.

There's another cell, microglia cell, astrocytes. These have various jobs in the central nervous system in the brain, and that interaction between the mast cells and these other cells, those cells can produce mediators, mast cells can produce mediators. And if there's some signal that sort of keeps this process going, you can see how you get inflammation and then eventually probably neurodegeneration.

The other thing that I'll say is that in the patients that I've seen who have MCAS who develop Parkinson's, all of them actually, I won't even say some, this is my patient population. So a hundred percent of those patients have an underlying infectious disease process or a toxic exposure such as mold that has allowed the mast cells to continuously be activated in a state that then leads down to that path.

I don't think mast cell activation syndrome itself is necessarily enough to cause the, that condition or other neurodegenerative diseases. There has to be something that is continuously causing, that continues to active continued activation of the mast cell.