Is Cycling Low Dose Naltrexone (LDN) Beneficial for Cancer Treatment? 

Answered by LDN Specialist Pharmacist Dr Sam Lebsock
Dr. Sam Lebsock

Is Cycling Low Dose Naltrexone (LDN) Beneficial for Cancer Treatment? 

A patient stated:  Unknown to my consultantI have had chemo and radiation treatment and have been taking LDN from the beginning of my diagnosis with stage 4 colon cancer.  I am not cancer-free but my tumor is much smaller than it was and no longer metastasized. I feel well. 

They are wondering if there is any solid evidence that LDN is effective for cancer and if there is any evidence that cycling the dose will be helpful.  There are some prescribers who like to cycle their LDN, specifically with cancer.  Some suggest four days on, three days off or three days on, four days off. Generally, they're taking that with CBD and cycling it. 

Then there are prescribers who like you to take LDN every single day. Remember the half-life of LDN is six hours so technically if you're only taking it once a day it is similar to cycling because it blocks the receptors. Then you come off and it unblocks the receptors. 

There are research papers that have been written in LDN in various cancer states, even with cancers and metastases. You can go to the LDN Research website and you can search cancer.