Do You Build Up Tolerance to Low Dose Naltrexone (LDN)?

Do You Build Up Tolerance to Low Dose Naltrexone (LDN)?

In Pam Smith's prevention about LDN for COVID she listed possible tolerance to the beneficial rebound effect under side effects but this wasn't discussed in the presentation. Can someone explain how that might happen whether you've encountered it and ways to mitigate it? 

Okay, so um I'm not really seeing tolerance to LDN um and I don't know about a beneficial rebound effect but what I will say is that in her protocol using Low Dose Naltrexone. Um we have seen very good results in reducing inflammation throughout the entire body. It is a typical dosing protocol once a day. Um, it is an oral medication protocol.  The side effects are similar in just about any other situation, perhaps some vivid dreams, perhaps headache once in a while um maybe some GI disturbance but maybe you're talking about the issue when you increase the LDN dose and then you get to a certain dose and you're on that for a while and then it just kind of seems to stop working.  Then what we do is we take somebody off of LDN for a little while and then we start all the way down at the bottom and slowly increase again.  So perhaps that's what you're talking about tolerance and rebound um but again, that is not a factor of the drug,  that's actually a factor of what's happening at the cellular site and how that interaction between low-dose naltrexone and those different cytokine receptors, toll-like receptors is actually happening.  So um it feels like an intolerance or you've hit a threshold and now it just kind of stops working and that but it's really not the drug because remember LDN doesn't cure anything right it just tricks the body into working on its natural pathways.