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Do you notice any additional benefits in patients taking LDN twice a day versus just once a day?
Some people are taking LDN twice a day, but it's very specialized and it's on an individual, like one to one basis. So I wouldn't want to answer.
Generally, for 99.99% of people, taking it once a day is the best thing to do. There are some people who can try taking LDN twice a day and do get a benefit, but it's really up to your individual prescriber, their knowledge and your condition to make that decision.