Do You Recommend Taking Low Dose Naltrexone (LDN) in the Morning?

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Answered by LDN Specialist Pharmacist Dr Sam Lebsock
LDN Specialist Pharmacist

Do You Recommend Taking Low Dose Naltrexone (LDN) in the Morning?

I've been taking  4.5 milligrams of LDN capsules for almost six years and have always taken it at night, as that was recommended to me when I started. 


 Do you recommend taking it in the morning these days?  This is a great question, actually, because historically, we always did say take it at night because that's when endorphins were thought to be made. Well, recently, a lot of patients have started taking it in the morning. Maybe it was affecting their sleep so much that they didn't want to take it at night, and the thing is, we're seeing the exact same effects if they take it in the morning than if they take it at night. So, if you're controlled at night, I would just keep taking it at night. If you struggle with night, then I would try morning doses and stay there.  If you notice maybe there's a stall when you're taking it in the morning, maybe try switching it back to night. So historically, as I said, we did tell people to take it at night. Now we're a little bit more flexible, I would say, with that type of situation.