Does 10 mg Low Dose Naltrexone (LDN) divided Twelve Hours Apart have any Cautions?

Does 10 mg Low Dose Naltrexone (LDN) divided Twelve Hours Apart have any Cautions?

I read this question a couple of different ways.  I'm not sure if you have a 10mg tablet or capsule, and you're trying to separate that and do five milligrams in the morning and five milligrams at night. Or if you're actually doing 10 milligrams twice a day.  I'm going to answer this in a couple of different directions. If you have a capsule, if you have a compounded capsule please do not open it.  Do not ever open it up and try to divide it and separate it out, even if you're trying to chase 10 milligrams but, more typically 41/2 mg. I don't know how you're going to find that little bit in amongst a total of about 130 milligrams in a size number three capsule which is the total volume. So if you can imagine 130 marbles running around inside of a capsule and 10 of them happen to be LDN they're all white, so how do you identify one from the other?  Please don't separate your capsules.  It's not accurate, and your dosing will be literally all over the board. However, 10 milligrams is kind of getting outside the low dose range, right, so in the US  we see upper range doses above four and  8mg, especially about eight milligrams used for weight loss, and that weight loss protocol is twice a day, so if that's the question we do see anywhere from eight to 16 even 32 milligrams used and that's in a commercially available product called Contrave, and there have been many studies that is an FDA approved product and the dosing on that is every 12 hours. If I miss something in your question, please type it back in so that we can follow up with the detail on that.