Does High, Continuous Doses of Low Dose Naltrexone (LDN) Foster Cancer Progression?

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Answered by LDN Specialist Pharmacist Dr Sam Lebsock
LDN Specialist Pharmacist Dr Sam Lebsock

Does High, Continuous Doses of Low Dose Naltrexone (LDN) Foster Cancer Progression?

Reading an article claiming that high doses and continuous administration of LDN can foster cancer progression, whereas Low Doses and intermittent treatment may have potential anti-cancer efficacy?  Is it important to take it intermittently?  I don't know if I necessarily agree with the first part of this statement.  I don't know what they mean by high doses or continuous administration.  Taking LDN daily for cancer has been widely used and it's widely studied for numerous different types of cancer.  You can find the abstracts on the LDN Research Trust website.   I encourage you to go there if you have a specific cancer that you are wanting to research with LDN.   I don't know if I would necessarily agree with this statement. Like I said, daily dosing could be considered intermittent dosing because the half-life is only six hours.  Generally that is how it is taken.  If you were asking about maybe this boarding on three day off thing that has been studied and is used by certain providers I don't think necessarily one is better than the other.  It's really on the preference of the provider and what type of cancer they are treating.  I hope I interpreted that question correctly.  Michelle or Janine anything that you wanted to add to that. 

 The study looked at high doses that was the typical 50 to 300-milligram dose right and we know that there's liver issues associated with those. You can see changes in liver functions with higher doses.  Whether or not that leads to cancer who knows?  I  don't know how that one-to-one correlation happens.  What I'm going to say is that it's not one or the other.  It's not high dose and everyday versus low dose and intermittent.  It's not one or the other.  You can do Low Dose and every day and still be anti-cancer because as Sam said when we looked at the studies with the B cell lymphomas, the breast cancer, pancreatic cancer, even cancers in the GI tract.. that was everyday dosing and it was low dose.  It was under 4.5 or less.  Those had tremendous outcomes.  We know that Low Dose Naltrexone actually binds to the opiate growth factor receptor we can see tumor regression.  Again that's done with everyday dosing.  

Is there power in one one study?  Yeah sometimes there is but again that was at high doses.  So it's not high doses and every day versus Low Dose and intermittent you know four on three off.  You can do Low Dose and every day and still get tremendous results.  And you're right Dr Khan has spoken on this in the past, Dr. Dalgleish, he studies this extensively with cancer and also talks about C-- and its activities as well and again very very well studied.