Does liquid or sublingual Low Dose Naltrexone (LDN) need to be refrigerated?
Is it okay that I haven't kept the sublingual drops in the fridge? I want to make sure it's still safe to take.
There are rules in the UK that when we make things inside the pharmacy, rather than have to be made in a factory, that we have to apply certain standards to those.
For example, our 1 ml liquid, which is made in the pharmacy, was sent away for analytical testing to enable us to have up to twelve months stability at room temperature. So we know if you don't open a bottle of the 1 ml and you leave it on a counter at 20 degrees centigrade for twelve months, it will be absolutely fine at the end of twelve months.
However, the sublingual drops are formulated to have as little excipients or as little additives to them as possible. So those are recommended to always be kept in the fridge and to be discarded after the 28 days once they're opened. If it's unopened and it's been kept out of the fridge and not been opened at all, I wouldn't have any problems with using that. Once you open the bottle, 28 days is the time you probably should be discarding it.
(When sealed, you can keep it for 90 days, but after you've opened it keep it in the fridge and discard any unused after 28 days).