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Low Dose Naltrexone (LDN) can vary from pharmacy to pharmacy depending on the quality of the pharmacy since it is compounded and also what form it is used in. If the LDN is used transdermally-- it will depend on the base it is put in. I put mine in Xematop since this is a base that is anti-inflammatory. If it is oral --then it will depend on what fillers they use in the pill or capsule.