Is The Dose For  Mast Cell Activation Syndrome and Autoimmunity The Same?

Is The Dose For  Mast Cell Activation Syndrome and Autoimmunity The Same?

Is the dose for Mast Cell Activation Syndrome and autoimmune immunity the same? That's the first part of this question.   I would say no.  This is very patient specific. Mast cell, I would say that I only see probably 50 of my patients who have mast cell, on LDN because first you have to get their histamine under control before you do anything else.  So that's kind of a long road in itself because mast cell is a very unique and patient-specific disease because everyone reacts differently. That's the first part of that question.  

Are doses above being  4.5 being immune balancing and doses below 4.5 being immune inhibitory?   I think of LDN as an immune modulator.  Depending on what's happening with your immune system it might treat an overactive immune system or an underactive immune system.   I think it's very dependent on what you're taking it for and who you are.  Any other thoughts from you guys on that?  You know I  would like to see the science behind that.  I have and perhaps maybe one of you has actually seen that.  Below 4.5 milligram being immune balancing and doses above 4.5  milligram being immune inhibitory,  I have not seen the science in that.  I do know that when we look at typical dosing of Naltrexone at 50 milligrams or even 25 milligrams though then we do see different activity but I will say that there's a lot of prescribers I mean even Paul Anderson talks about using up to six milligrams in some situations, especially when there's multiple immune issues going on or autoimmune diseases. 

I respectfully disagree with that statement that below four and a half it's immune balancing and above its immune inhibitory.  I have not seen the science.  I would be open to seeing what that is but I don't think that is very definitive black and white statement like that can is always what we see.