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What is the best dose of LDN for Hashimoto's? What I have seen is a little bit less than three or around three milligrams I don't know. But usually, when you go to higher doses you lose that loss of like reduction of the antibodies and that's mostly I think for the prescriber they can still I'm sure they do test all the time and see it better. Usually, I start at 0.5 and move up by 0.5.