Effects of Naloxone and Naltrexone on Locomotor Activity in C57BL/6 and DBA/2 Mice
Administration of naloxone or naltrexone in DBA/2 mice was followed by dose-related depressant effects. The locomotor activity of the C57BL/6 (C57) Ss injected with naltrexone was also depressed. Low doses of naloxone induced a decrease in activity in C57 Ss. This effect gradually disappeared at intermediate doses and recurred again at higher doses. Results are discussed in terms of differences in type number and/or distribution of the receptors influenced by naloxone and naltrexone in the 2 strains of mice tested.
Keywords provided: naloxone, naltrexone, locomotor activity, inbred miceKeywords by Erin Williams, student, St. Louis College of Pharmacy