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Generalized familial benign chronic pemphigus (Hailey-Hailey disease) treated successfully with low-dose naltrexone
JAAD Case Rep
16 August 2018
https://pubmed.ncbi.nlm.nih.gov/30167446/
In addition to recent reports showing the effectiveness of LDN in HHD, it is currently being used in a number of other disorders including multiple sclerosis, fibromyalgia, and Crohn's disease. Until this point, treatments have only modified the disease, as they have not clearly targeted the pathophysiologic components. Despite the uncertainty of mechanism of action, LDN in this patient as well as a few other documented case reports of HHD treated with LDN, led to dramatic clinical improvement, with minimal side effects. t would appear to be the treatment of choice for HHD when more conventional treatment modalities fail. Moreover, its use provides a powerful addition to the therapeutic armamentarium for generalized HHD.