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Hailey-Hailey disease treated successfully with naltrexone and magnesium
JAAD Case Rep
29 August 2019
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728728/
Hailey-Hailey disease (HHD), or benign familial pemphigus, is an autosomal dominant genodermatosis that usually presents between the second and fourth decades of life as painful blisters and erosions in the intertriginous areas.1 It is characterized by a remitting, relapsing course, and recurrent episodes of superinfection. HHD is caused by mutations in the ATP2C1 gene.
Although HHD is not life threatening, it has a significant negative impact on patient quality of life. Many treatments exist, but none is highly effective. We report a case of a patient with recalcitrant HHD dramatically improving with the combination of oral magnesium chloride supplementation and naltrexone.