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Halberd/Athena GTX Research Promises a Much Brighter Future
pharmiweb.com
Halberd Corporation
22nd May 2024
Effective medications for substance abuse and co-morbidities- specifically, effective medications for the various core substances linked to abuse with and without the co-morbidities of TBI and PTSD.
LDN+: This novel combination of low dose Naltrexone and Cyclobenzaprine, patented by Halberd, has a half-century of medical usage behind it. While there are thousands of articles attesting to the analgesic effects, such as https://link.springer.com/article/10.1007/s10067-014-2517-2, all relate to the endorphin release as a contributing factor. The most prevalent hypothesis, advanced by Dr. Ian Zagon and colleagues, states that inducing a small and transient opioid blockade will prompt the body to compensate by upregulating both endogenous opioids and opioid receptors https://www.sciencedirect.com/science/article/abs/pii/S0306987708005070… and anti-inflammatory capabilities at the neural level. While the use for chronic pain has been well described, we believe that acute pain can be modulated especially in combination with low dose Cyclobenzaprine. Cyclobenzaprine, in micro-dose has been ill-studied as well, but the effect is not dissimilar to low-dose Naltrexone, yet in combination, we have seen what we feel to be marked improvement over Naltrexone alone. In micro-dose, the side effects of Cyclobenzaprine are virtually non-existent. https://www.ncbi.nlm.nih.gov/books/NBK279656/ Note: While this product has been patented and used effectively and safely in patients, to be available on a commercial basis would involve a simple safety study for final submission to the FDA for approval, though currently can be compounded in physicians' offices for use for their patients. The key to our work now is to complete the studies as no commercial form of Low dose Naltrexone or low dose Cyclobenzaprine is available.
Effective psychotherapies for substance abuse and co-morbidities, specifically examining integrated and sequential approaches for addressing SUD and PTSD in military veteran populations.
There is no clearer call for solutions than this and our current pilot study directly aligns to this need. Our pharmacological interventions, when added to 24/7 physiological and psychological monitoring and help access, tied to providing state-of-the-art therapies including yoga and meditation is a game changer. The program is called Watchdawg™ and includes state-of-the-art assessment and therapies available to those suffering the most. We also know that the current thrusts are for troubled veterans to seek out-of-country "magic mushroom" therapies. We should and must do better with lower risk, lower cost alternatives. Watchdawg will do just that.
Effective complementary and integrated approaches to treating pain and co-morbidities in military/veteran populations (e.g., mindfulness, hypnosis/meditation, etc.), specifically testing a variety of non-pharmacological approaches to treating pain and co-morbidities in these populations.
We understand the issues and the individualism in patients and the general acceptance and resistance to COTs (Chronic Opioid Therapies) pharmaceuticals and adjunct therapies such as yoga, CBD, etc. Fact of the matter, we see the physiology and psychology of the individuals differ and yet often are related. Our Watchdawg program sits at the crossroads of therapies that work and the patient dynamics. Interestingly, LDN+ could also be therapeutic in the following conditions not outside of issues with active-duty military personnel and veterans:
Pain- an analgesic (pain-relieving) effect;
Neurological Conditions- beneficial for multiple sclerosis (MS) and Parkinson's by reducing inflammation and promoting neuro-protective effects improving the quality of life;
Mood and Mental Health- benefit for mood disorders such as depression, anxiety and PTSD, often a trigger for drug and alcohol abuse; Cancer - an adjunctive multi-layer program which may help modulate the immune system while providing an overall relaxation;
Modulation of the Immune System- has shown key immunomodulatory effects in rheumatoid arthritis, multiple sclerosis, and Crohn's disease; and sleep studies have reported improvements in sleep quality as lack of therapeutic sleep is common in military veterans.
Visit link for full article .. https://www.pharmiweb.com/press-release/2024-05-22/halberdathena-gtx-research-promises-a-much-brighter-future