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Explore the groundbreaking research presented at LDN Conference 2024 by Angus Dalgleish. This session delves into the analysis of gene lists using unsupervised methods to identify novel therapeutic targets for cancer. Discover how gene categorization and advanced software reveal significant alterations in cell cycle proteins due to low-dose naltrexone (LDN) and naltrexone (NTX) treatments.
The sort of magnitudes of changes in exam lists look look like as shown and I'm not going to go through all those but they start with lucasite associated receptors going all the way down to GGI associated uh ones. Software can be used to search for patterns. patterns can suggest new targets. They are very complex and there are other ways. So we looked at categorizing genes. Sort genes into categories genes common to both. Categorize and analyze using pathway studio which is a program to do this. Generate the lists and the top 10 are both global and unique and involve the cell cycle. The unique gene profile that are altered by lowd dose nrexone and unchanged by nrexone are shown on this slide 21. We just focus on the top 20 and we troll through them and we show hits which are interesting and we have looked at these in detail and confirmed with western blotss. On the next slide, westerns, we confirm the effect of treatment on proteins which ultimately control cell function and the effect of nrexone and lowd dose nrexone for 48 hours and assess genes identified by genetic fingerprint being pro-apptootic cell cycling proteins and cell signaling. Their hit on cell cycle proteins is quite marked.
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