How do you deal with breakthrough pain while taking Low Dose Naltrexone (LDN)?
If you take LDN in the morning, how should I deal with breakthrough pain during the night due to small fibro neuropathy?
So again, it's not a time of action, it's a biological function you are gradually reducing inflammation. So it could be that you might want to start taking your LDN in the afternoon and see if that helps. It could be that the anti-inflammatory effect might be more potent a few more hours that way. If you take it in the afternoon, you won't risk as much of the interference of your sleep pattern.
Generally, if you have breakthrough pain in the middle of the night, then taking painkillers before you go to bed, like paracetamol, ibuprofen or whatever you have, would not be a problem. You don't have to stop all painkillers when you're on LDN and there's no reason not to take other painkillers for breakthrough pain as long as you're not taking them at the same time as the LDN and they are not morphine or opiate based.