How Does Low Dose Naltrexone (LDN) Impact Microglia and Astrocytes?

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Dr Norman Marcus, Pain Specialist
Pain Specialist Dr. Norman Marcus

How Does Low Dose Naltrexone (LDN) Impact Microglia and Astrocytes?

Can you say more about how LDN impacts the microglia and astrocytes?  Most of the data is on  the microglia in terms of the glia.  That's important in the phenomena of chronic pain.

So what I presented was based on the studies on microglia, and I'm not familiar with astrocyte studies.  We know that astrocytes are contributing, but of the three microglia, of the three glia, the typical glia oligodendrocytes, astrocytes, and microglia, microglia appear to be the most important for the chronic pain presentation.