How to Dose Low Dose Naltrexone (LDN) for PTSD

LDN Specialist Pharmacist Michelle Moser
LDN Specialist Pharmacist Michelle Moser

Multiple-Day Dosing for PTSD with Low Dose Naltrexone (LDN)

If taking LDN three times a day for PTSD, how is there enough time between doses for the drug to wash out and allow the endorphins to increase? Well, that's a really good question. So,  Dr. Forrester and Dr., Lanus spoke about using multiple-day doses multiple times per day dosing of LDN in anxiety, depression, and  PTSD back in the 2019 conference,  which was one of my favorite conferences in my entire existence.
And they work very, very carefully with their specific patients and a lot of times the doses aren't necessarily uh typical every eight hours.  Sometimes they're a little bit closer together at one part of the day or the other. But again, it's very specific to that patient. So you're right if the half-life of LDN is four to six hours if you're taking it every eight hours, you have a  very short window for the potential for receptors to upregulate and increase endorphin production.  
I will say that usually, with three times a day, dosing compliance is difficult.  
So usually there are some changes that way as well.  Sometimes twice a day dosing is just as helpful, but again this is very, very specific. I'm hoping that Dr. Lanus and Dr. Forrester come back and talk again about it in another one of the  LDN conferences because they do a fabulous job of speaking on the use of LDN and PTSD specifically.