How Long Does it Take for Low Dose Naltrexone (LDN) to Help with Dermatological Issues?

Clinical Pharmacist Nat Jones
Answered by Nat Jones, R.Ph. FAPC

How Long Does it Take for Low Dose Naltrexone (LDN) to Help with Dermatological Issues?

I have noticed from interviewing people that dermatological conditions take longer to respond than other autoimmune conditions.  For example, like the alopecia brexit syndrome, Haley Haley's disease, psoriasis,  and vitiligo.  I found that some people need six to nine months of using it. Then there are people who want to see results quickly, but it doesn't seem to be a quick fix.  Especially alopecia. Sometimes it's nine months to a year before you see any change at all.  

I think it's important when you're talking to patients to set realistic expectations on when they will see some potential outcome.  It's not like we're going to affect their mood within a couple of weeks by taking a small dose of Naltrexone.  It can happen kind of quick, but if you're looking at fixing an underlying autoimmune condition there's a lot of  layers.  In fact, if you look at the immune system there's a lot of layers involved.  It takes a long time to turn off the inflammatory process that's associated with these diseases.  I would agree with you.  I've told patients regarding diseases, like psoriasis for example, that it will be at least six months.