How long does it take to notice the effects of Low Dose Naltrexone (LDN)?
Well, it depends on what you're trying to go after. With some sleep issues, pretty rapidly, within a few days, some people can be relieved of insomnia. Although LDN can sometimes cause sleep imbalance or sleep issues the other way, insomnia, for instance. Sometimes folks with insomnia will see, once they start LDN, within a couple of days, it helps.
I've had some people report within a day of starting LDN that some psychiatric issues have abated, anxiety, depression.
If you're looking for an anti-autoimmune effect, you're going to have to give that weeks to months for effect. It usually takes a month or so to titrate up to an effective dose anyway. And I'm quick to use bid (twice daily) dosing and pairing it up with other agents for added benefit.
That all takes a little time. You never want to quit LDN unless you've gone at least three months. And then a lot of times people, it's so subtle they can't really report if it's effective to you. Tell them to stop it for a week and report back. They'll usually call and say: “You know what, I didn't realize how it was working or that it was working, but when stopped taking it, a lot of my symptoms came back and I don't feel as good”. So, they get back on it. Sometimes it's just some subjective feedback at the one-month, three-month mark. I would never have somebody quit it if they hadn't been on it for at least three months.