There is much in the way of individuality regarding how LDN works on folks. Placing a time on how fast it will work is not an appropriate way to look at how this intervention works. For most autoimmune (AI) disorders, it will take weeks to months to realize a major effect. For the pain associated with FM, it may take only a few days to ''feel'' less pain. The AI reducing effects can take months. Best bet is to take this intervention and the titrations to a therapeutic dose with patience. Failure to realize any benefit should only be after 3 to 6 months of therapy.