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Hypothyroidism - Dawn Ipsen, PharmD (2021 Conference) (LDN, low dose naltrexone)
Dr. Dawn Ipsen is a compounding pharmacist who presents on some roles low dose naltrexone (LDN) may have in helping patients with hypothyroidism. She discusses hypothyroidism, its prevalence, and treatment goals.
It is known that excessive supplementation can lead to arrhythmias and osteoporosis, but left untreated, hypothyroidism can lead to cardiovascular disease and increased mortality, it can increase the risk of infertility, and even lead to poor brain development in children. Patients are at higher risk of having hypothyroidism if they already have autoimmune diseases and other conditions she discusses. Monitoring the ESR and the CPR rates may be good markers of inflammation and autoimmune conditions.
She talks of the different subtypes of hypothyroidism, and thyroid hormones used to treat hypothyroidism. Not all thyroid preparations are bio-equivalent, she cautions. Dosing and follow-up of thyroid hormones is discussed. Because inflammation is a huge cause of autoimmune disease, and can cause excessive levels of cytokines, inflammation needs to be addressed.
LDN is an off-label therapy for many autoimmune chronic conditions that are inflammatory based. She discusses its mechanisms of action. When LDN dosing, keep in mind that with patients with hypothyroidism, one must cautiously increase more slowly and monitor as needed, as in some patients it can swing them into hyperthyroidism states. She shares a couple of case reports.
In summary, hypothyroidism is often accompanied by states of inflammation due to various causes. Inflammation can precipitate autoimmune disorders. LDN is a medication with significant safety data, and tried around the world to help improve symptoms of subclinical hypothyroidism, overt hypothyroidism and autoimmune hypothyroidism thyroiditis.
KEYWORDS: autoimmune, thyroid, hypothyroid, Hashimoto’s, Graves', vitamin D, immune, Crohn's, psoriasis, hormone, Hashimoto’s, infertility, anxiety, depression, nutrition, pregnancy
This is a summary of the presentation. Click on the video for full information.