If a MCAS patient has additional ailments, what should be treated first?

If a MCAS patient has additional ailments, what should be treated first?

What do we want to treat, the chicken or the egg? So, if the disease is due to MCAS, then we need to treat that because they won't tolerate the drugs. And that was shown in Dr. Blitzen's and my paper in November 23, looking at just a case series of good patients to demonstrate changes who failed psych therapies. 

Then they were seen by me or Svetlana in Buffalo. And then we diagnosed them with MCAS, treated them for MCAS, and they got better. One of these patients who's presented as a patient who exemplified such qualities was treated for refractory GI symptoms with hydroxyurea. 

And this drug, which is normally used for various conditions, but mostly a haemological disorder, got better. Not only did her GI symptoms get better, but she called me up and said, should it work on my depression? 
Because I've had lifelong depression and had suicidal thoughts every day, and now I don't. So just with aggressive therapy for MCAS, she got a lot better in the brain. So that exemplifies what we've talked about earlier, that these mediators go across leaky barriers, including the blood -brain barrier and the gut barrier, and that causes havoc in our system.