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Off-Label, Low-Dose Naltrexone for Refractory Painful Diabetic Neuropathy
Pain Medicine
April 2016
http://painmedicine.oxfordjournals.org/content/early/2015/11/25/pm.pnv009
A case in which off-label LDN was used for the treatment of painful diabetic neuropathic pain refractory to most available therapy. We feel the need for further research to elucidate the possible mechanism(s) of LDN focussing on the roles of endogenous opioids and neuroinflammation, and to conduct large randomized, double-blind, clinical trials to establish the possible mechanism, efficacy, and safety of LDN in painful diabetic neuropathy and other chronic painful conditions.