LDN Video Interviews and Presentations

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Radio Show interviews, and Presentations from the LDN 2013, 2014, 2016, 2017, 2018 and 2019 Conferences

They are also on our    Vimeo Channel    and    YouTube Channel

Dr John Kim, LDN Radio Show 2016 (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Linda Elsegood: Today I'm joined by Dr. John Kim from Georgia Integrative Medicine Clinic in the US. Thank you for joining us today. 

Dr John Kim: Oh, you're welcome. It's my pleasure and honour to share this wonderful therapeutic known as low dose naltrexone. 

Linda Elsegood: Thank you. So could you tell me your qualifications, please? 

Dr John Kim: I am a physician originally trained in family medicine, then Chinese medicine, integrative medicine, preventive medicine, public health. I think before I went to medical school, I was doing basic science research in biochemistry, and I was a Howard Hughes Medical Research Fellow for pharmacology. 

Linda Elsegood: And when did you first hear about LDN? 

Dr John Kim: So this interesting part is that I have gone through two residencies, two fellowships; including an integrative medicine fellowship with Dr Andrew Weil at the University of Arizona. Those times spent in training I'd not heard of LDN. I did not learn about LDN actually until a patient of mine came to me and said, “Hey, listen, I have a thyroid issue, and I've done this research, and I just can't get a doctor to prescribe me LDN or low dose naltrexone. Would you at least do the research for me? Because you're one of the few doctors that listen to patients. And you have an open mind?” So I said, sure, let me do the research. And when I did the research, I was very surprised by the fact that this has been well-documented and utilized extensively since Dr Bihari’s use in New York, and all evidence seems to indicate very little risk and all possibilities of benefits.

So I told the patient, yeah, sure, let me go ahead and I'll prescribe the medication, and it's going to be a bit of an exploration on both parts. And amazing things began to happen. Not only her thyroid issues began to reverse and over several years not only her thyroid issues reversed, but she conceived and delivered a baby.

And so. That person made me think a lot about the possibility of what else is possible with LDN. Me being a cautious practitioner I had to go very slowly for the next about five, six years; and I would target other patients with thyroid conditions. And I began to see a pattern that I can't do with other medications. Because with all the medications in conventional medicine, we can replace thyroid hormone in different forms, but I don't have a possibility or ability to reverse illness, reverse thyroid disease. We just let it go until it goes into total failure, and you just up the dose. And in this case with LDN, I began to see patients whose doses can be halved, and other patients would basically become drug-free. And then other cases I would see the antibodies related to hypothyroidism lowered in number.

Linda Elsegood: And did any of your patient's experience negative side effects when first starting LDN?

Dr John Kim: In the beginning, none of the people really experienced any of the side effects, but as I began to use LDN more in-depth, I began to see side effects. One of the things I've run into is that typically the LDN low dose naltrexone in the literature is considered between 1.5 and 4.5. But I've noticed that in patients with what I call low endorphin reserve, where a patient has been sick for a long time, patients not feeling well for a long time, their daily activity is compromised; in those patients, I've seen that the 1.5 milligrams can have a paradoxical effect. Patients can not sleep. You tend to create insomnia. And I think that's well documented. In patients with PTSD, the LDN also can cause vivid dreams related to the PTSD; or further, create trauma. And in such cases, I began to experiment with lower doses. So I would begin using 0.5 milligrams or even lower. Now today I start even at 20 micro micrograms, and then I'll do a rapid ramp to get them to 1.5 milligrams. 

Other side effects that I've seen is some nausea. I have patients that could not even tolerate one microgram of low dose naltrexone; they just feel really, really bad and in pain. So again, I think that their endorphin reserve is quite low and they’re not tolerating this dose. 

Linda Elsegood: And you were talking about thyroid conditions. Have you prescribed for other autoimmune conditions now? 

Dr John Kim: Yes. Oh, you know, it's thyroid Hashimoto's thyroiditis. One of the first things that I started treating when I saw the effectiveness of LDN for treating thyroid conditions - I said, Hey, if it works for Hashimoto's thyroiditis and the mechanism is through correction or modulation of our immune system, why not? Why wouldn't it be a shift in theory, work for Graves’ disease? So I began to treat patients with Graves’ disease.

Graves' disease is very interesting because the response to LDN in Graves' disease is maybe somewhat lower than with Hashimoto's thyroiditis. I have several patients who are doing very well, and they are in remission from Graves' disease with using nothing more than low dose naltrexone.

As I can understand the mechanism by which LDN works I decided that maybe we can do more. Again, the literature also helps us. So I began to treat patients with MS and we just got some amazing results, including one patient who is actually in remission from MS. She almost was not able to walk, and now she's climbing Mount Kilimanjaro and travelling all over the world and being able to enjoy a very high quality of life. And then other rheumatological conditions, such as psoriatic arthritis and many, many other conditions. 

One thing that I really noticed is that through my practice I'm beginning to see LDN beyond just what we accept in literature. For example, I have some patients with dementia and Parkinson's disease and LDN I believe has helped to mitigate or slow down, or some cases reverse - not fully - but some effects of dementia and Parkinson's disease.

Linda Elsegood: What about cancer?

Dr John Kim: Cancer is one area that I think - I recently accepted a position with Miami Cancer Institute with the Baptist Health of South Florida, and the reason for that is that in my current private practice, I think that my experience with autoimmune diseases have been extensive and I've seen excellent results with low dose naltrexone for treating autoimmune conditions. But for cancer, to be honest, I just don't have enough patients coming to me who have cancer, and the patients that I've treated with cancer, I am not able to say that it works or doesn't work with cancer.  What I have seen is studies, especially by Dr. Berkson in New Mexico, who is combining the low dose naltrexone and alpha-lipoic acid. So I began doing that as generally part of my treatment of cancer, but I'm looking forward to my new position where I will be able to see more of those patients.

Right now, I have developed a bit of reputation to help patients with autoimmune conditions. I see a lot of patients with autoimmune and different kinds of autoimmune conditions, and that has really helped me to understand the function and utility of LDN for autoimmune diseases. So what's interesting to me is all the cases where I am using LDN may be somewhat different from other people. One of the things that I've utilized LDN for is the gene for insomnia because one of the things that LDN does is to increase REM sleep, decrease sleep disruption; and also enhances people’s ability to fall asleep. And that's one of the reasons I think, unfortunately for the patients with PTSD, that doesn't work as well, because these may get them back to the conditions or memories that are very traumatic because it's very, very vivid. 

The other things that I’m treating are things like tinnitus, migraine, endometriosis, and infertility. What I'm seeing is that LDN has multiple chemical functions. So one is, its modulation of proinflammatory cytokines through the clear cell in the central nervous system. And that's the primary response to invaders if you will, in our central nervous system. And as such LDN is a very valuable tool. 

But in addition, it seems like LDN has other functions, such as it seems to have a very calming effect on the nerves. So LDN can be, I think, used very effectively for treating neuropathies of all different kinds. Also, as I mentioned earlier, it's almost like an adaptogen all by itself, so I often use LDN to treat patients with a mood disorder because having more endorphins seem to make patients respond better to the conventional and nonconventional treatments of depression and anxiety. Because it's kind of hard to feel depressed when you're feeling good, and endorphins give you that edge that feels good. So while you feel good, it's difficult for you to feel either anxious, or feel good and depressed at the same time. 

Linda Elsegood: What do you do with patients that are already on strong opiate painkillers when they come to you? 

Dr John Kim: So those patients are very interesting. About 50% of my practice is treating patients with severe pain using neuro-anatomic techniques, and I don't prescribe any narcotics at all. But we have a good track record of helping patients to get off narcotics, and in this case, we use a phenomenon of low dose naltrexone, utilizing microdose naltrexone, also known as ultra-ultra-low dose naltrexone. And in this case, we use micrograms of naltrexone. Again, as I said, the usual dose that people use of naltrexone is about 1.5 milligram to 4.5 in LDN amounts. But it's very interesting because you can take microgram doses, which is a thousand times less than milligram doses, and there are studies that demonstrate that a microdose of naltrexone results in better pain relief, and it also lessens the side effect.  I have a couple of patients treated with this ultra-low dose of naltrexone, and they’re doing great. Great, great, great response. Because I have chosen not to prescribe for narcotic, they still go to their pain doctor, and the pain doctors are quite pleased because usually if you just give narcotics alone, the doses have to go up, up, up, up, up, and that's when you have overdose phenomena and people get in trouble. But in this case, what happens is that with the combination of the low dose naltrexone and the neuro-anatomic approach to pain that I developed over 20 years, we can actually reeducate their central nervous system and lower the dose of narcotic, while the patient is reporting much-improved pain. Such techniques, actually, I think to warrant a lot of research oncoming because of the obvious problem with the narcotic overdose that is going on in our country. As a matter of fact, there's medication right now that is being studied combining ultra-low-dose naltrexone and narcotic medication. It's not been approved yet, but there'll be interesting how the Oxytrex will work for patients. 

Linda Elsegood: Do you keep them on the ultra-low dose, or do you increase it over time? 

Dr John Kim: As their narcotics amount goes down, then I march it up because, with low dose naltrexone, I think that there is a benefit. I think the key is to start the patients depending on their narcotic history and narcotic use history and their functional assessment of the endorphin reserve status, and then trying to match that clinically. And then generally I march them up. LDN really has been an invaluable partner for me to get my patients well, 

Linda Elsegood: You also mentioned alpha-lipoic acid. What do you use as a protocol? Do you have a general protocol for it?

Dr John Kim: Absolutely. Dr Berkson's protocol of using LDN and alpha-lipoic acid is published; anyone can look it up. I believe that he uses IV though, so I researched more talking to pharmacists, and it seems like that protocol has a side effect that people can pass out. Also, if the GI system is working, I feel like that is the first thing that we should do.

So with alpha-lipoic acid, I generally like to utilize the controlled release form or slow-release form, and that also depends on the person's ability to take alpha-lipoic acid, because if you give 600 milligrams to everybody, some people who are very sensitive to it may pass out or get hypoglycemic symptoms because alpha-lipoic acid can be a powerful agent to lower blood sugar levels in diabetic patients. It also helps with neuropathy. I know that alpha-lipoic acid and LDN are a very powerful combination to reduce inflammation in the nerves. 

And that makes it interesting because most of the medications that we use do not necessarily work well in what we call a high-hydrophilic or -hydrophobic environment. A hydrophobic environment means that it's not easy for charged molecules to enter and do its job. LDN seems like it can penetrate very easily. Alpha-lipoic acid also is fat-soluble, so those two are very important. I believe that Dr Berkson’s protocol for utilizing alpha-lipoic acid may have to do with the function of keeping the blood sugar low, therefore allowing the tumour growth to be inhibited. But I think that again, a lot of studies need to be done. And that's one of the reasons I have accepted this new position in Miami for the Miami Cancer Institute. And I'm hoping that as the director of integrative medicine I will be given permission to explore the possible roles of using low dose naltrexone and other proven therapies in a system-wide manner. 

Linda Elsegood: Do you use vitamin D as well? 

Dr John Kim: Yes, of course, of course, I do use it. If it's low, I do supplement it. It's not a part of my protocol. Part of my protocol for cancer also includes fat-soluble vitamin C, that would be ascorbyl palmitate, because otherwise, you have to go through the vitamin C injections. I think that there are multiple responses you can get from vitamin C. So for example, high doses of vitamin C injections, that's been documented by Dr. Jeanne Drisko in the University of Kansas medical centre - I think that that research shows that the vitamin Cs can help the formation of hydrogen peroxide. And then the hydrogen peroxide goes after the tumour cells. In the dose that I'm using, I don't believe that vitamin C dose is high enough to do that. So it doesn't replace the need for IV vitamin C treatment. But again, it has to do with my current practice setting, that IV therapeutics is not very easy for me at this time. And by using the fat-soluble vitamin C, what I'm doing is overcoming the required amounts that can be taken in by the body.  There are no formal studies that fat-soluble increases the amount yet, but it makes sense to me. I think that fat-soluble forms of therapy can be extremely valuable.

Oh, another example of that is S-Ethyl glutathione where the ethyl group is attached to glutathione. Multiple people have tried to play with the different formulations, but I think that the actual chemical alteration to make the molecule more hydrophobic is probably cost-effective and the best solution for some of the molecules, to encourage them to go where they need to be going to do their job. 

Linda Elsegood: And you were saying that you weren't taught about LDN in medical school. Do you think that's likely to change anytime soon? 

Dr John Kim: I don't think so. I think about integrative medicine and how it is now being discussed, or at least covered more in elite medical schools. So if you look at the distribution of integrative medicine in the United States alone, really it's reserved for what I call first-tier medical schools like Harvard, Vanderbilt, Duke, Yale. But it has not really penetrated a lot of the regular schools with the exception of maybe the University of Arizona, where Dr Andrew Weil started the program. Even there, I think medical students have a lot on their plate. I don't think they get enough about nutrition. I think that the medical education system is arcane. What I would like to see is breaks in mores in residence level, where after doctors graduate medical school, they get trained. That's where the doctors learn to be doctors.

What I've done with my recent book, in some sections, I've even published the patients’ lab results - not patient's identity - but their lab results, so that they can see after treatment with LDN that the TSH would start low, and then the TSH would normalize. T-3 would be high and then it would normalize and then it would also see the antibody levels all responding. 

Linda Elsegood: I understand that there is a medical school in Oregon that actually teaches LDN to the medical students. So that has to be a start, probably. 

Dr John Kim: It has to start somewhere. I think that for me that integrative medicine means working with patients, and that has really helped me to learn about an LDN. The nature of my practice is about 50% dealing with intractable pain. The other 50% is dealing with patients who have complex problems that they really can't get answers on. And what I found is that LDN doesn't cure everything. I think that it's dangerous to say one thing can do everything. Like, if you do LDN, you don't still need to practice good medicine. 

But LDN can be an amazing tool for autoimmune diseases especially. A lot of the tools that we have are not benign tools, or you cannot use steroids forever, you cannot use immunosuppressants forever. And I think that LDN also helps you to understand the nature of the disease. I'll give you an example. I had the longest time thinking why, how can LDN work for HIV? So when I began to read more about HIV, I found out that HIV actually is not strictly an immune deficiency condition. It's really immune derangement, meaning that the immune system is not functioning the way it's supposed to be functioning. So similarly we can postulate, we can guess we can think about cancer. Is it also possible that a cancer patient's immune system is deranged? It's not doing what it's supposed to do?

So in my practice, in the beginning, when people have an autoimmune disease, we would just use LDN. And then inevitably we would have patients for whom LDN isn't good enough. It's not doing the job by itself. So what I have done is more research, more reading, and more talking to other people, and I found out something very fascinating. What I found out is that if you have an autoimmune disease, it makes sense to check the person's autoimmune profile. And what I mean by this is not by doing conventional testing of things like C reactive protein, doing and an ANA check, or ordering an immune profile. And of course, I do that. Part of my assessment is to screen for their developing other autoimmune conditions before placing them on LDN. 

But if the patient does not respond to LDN, I think that sometimes, doing additional testing, either allergy testing to see if there’s an allergy to both respiratory allergens -  things like fungus, trees, grass, as well as food allergens. Both IgE and IgG can make sense, because again, if we're looking at autoimmune diseases as immune derangement, then you're looking for places that immune system is not functioning the normal way. I think the LDN is a powerful tool, but as I said, there are patients who don't respond to LDN alone. 

One patient had a double rheumatoid condition, and LDN alone wasn't doing it, acupuncture wasn't doing it. So what I finally did is testing on the food section, and the patients stopped eating that food; and I used immunotherapy to reteach the body to forget, to let go of the allergens that person had. And the amazing thing happened. Both of her rheumatologic diseases disappeared to the point when she went back to her rheumatologist and said, Oh, we made a mistake. We're sorry. And the patient said, Hey, you mean to say that my lab and my x-ray were all conspiring together? That's unbelievable. That's not likely. I think it's more likely the LDN plus the immunotherapy that Dr Kim asked me to do, is working together. And it's resulting in this remission. 

Linda Elsegood: You've mentioned your book. Would you like to tell us the title of the book and when it will be available? 

Dr John Kim: I'm hoping that the book will be available in December. The press release went out some days ago. The title of the book, I put it as “Understanding Low Dose Naltrexone Therapy” and then its subtitle is “A Cure For All”. I mean the illnesses of cancer, and chronic diseases.  I have to contact my old editor and see if she is available to take the job, because she edited my first book and she did such a great job, so I want to see if she can edit this book as well.

Linda Elsegood: Do you expect that you're going to be moving? Can patients still come and see you before you move, or are you fully booked? 

Dr John Kim: I think patients are still coming to see me, and my understanding is that - when I interviewed with them, they assured me that even though I'll be in the cancer centre and seeing mostly cancer patients, I will not be forbidden to see other patients. I'm really hoping that it will be the case because I feel like the autoimmune approach that I've developed can help patients, and especially patients who are not good candidates for conventional medicine in terms of long term steroid use, or the immunotherapy itself can be very harsh to some patients. So I'm hoping that I would be allowed to do that. 

And the other part is that I have this idea that some forms of cancer may involve the host, the patients. Developing all that I said about the immune derangement, that maybe their immune system is obsessing over something else, maybe food allergens; or they have an undiagnosed autoimmune condition. I've seen that once you develop cancer, you stop looking because cancer is such a deadly condition, you want to zone in on that. What I'm hoping to do is be allowed to do other observations, observe their autoimmune conditions. It can be more formal in terms of formal research, or it can be just the clinicians’ observations.  

I  remember a long time ago in London, the cholera epidemic was controlled by a Mr Snow or Dr Snow, that did not know the mechanism. He just used epidemiology to isolate the wells that were likely to be responsible for cholera. He didn't know the exact mechanism, but all he had to do is shut down those wells, the old water pumps, and then he was able to help. The field of medicine relies on collaboration and cooperation, and that's part of the reason I've accepted the position in Miami. But I think there's still room for one person to make an

observation, then through communication through books or through organizations like your organization, to reach out and ask these questions that no one else has asked. 

Linda Elsegood: Thank you. And thank you very much for your time, and sharing your experience. 

Dr John Kim: Thank you for the opportunity.

 

Any questions or comments you may have, please email us at Contact@ldnresearchtrust.org.  I look forward to hearing from you. Thank you for joining us today. We really appreciated your company. Until next time, stay safe and keep well.

Deidre - US: Small Intestinal Bacteria Overgrowth (SIBO) (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Deirdre shares her SIBO and Low Dose Naltrexone (LDN) story on the LDN Radio Show with Linda Elsegood.

Deirdre first noticed an issue with her digestive system upon returning from Mexico. At the time, she was only 20 years old and the issues weren’t attributed to anything serious. However, this progressed to the point where her diet became very restricted and she was only capable of eating certain foods without triggering a reaction.

Her symptoms developed to the point where her joints began to ache and she sought out a solution to her problem, which is when she found that Low Dose Naltrexone (LDN) can be effective in treating patients with Small Irritable Bowel Syndrome (SIBO).

The LDN has enabled Deidre to expand her diet and return to regular exercise, removing the joint pain. In this interview she emphasises that she is hugely relieved and owes her recovery to LDN.

This is a summary of Deirdre’s interview. Please listen to the rest of Deirdre’s story by clicking on the video above.

Annie (2)  - England: Multiple Sclerosis (MS) (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Linda Elsegood: I'd like to introduce Annie from England who has multiple sclerosis? 

Good morning, Annie. Could you tell us when you were diagnosed with MS?  

Annie: I was diagnosed when, 30 years ago, so that would have been, golly, I can't even say what year I was the very late twenties, 29.

Um, but I had problems with my light eye from my teens, as it transpires it was probably the MS, but I've had it for quite a long time. 

Linda Elsegood: And how did it impact on you at that time being diagnosed? 

Annie: Um, well, they told me at the time actually, that I had a viral infection, and so I tested. Took it, but that was it. But they had actually written down on my notes that it was MS. And it wasn't until ten years later when I had quite a serious relapse, uh, that they sent me for an MRI scan. Then they said, they didn't tell me because it would have affected the quality of my life, but I'm glad they didn't actually because I would have been stressed out as it happens.

I had ten great years. Uh, I was not worrying about anything health-wise. 

Linda Elsegood: It's always a blessing, 

Annie: isn't it? Absolutely. 

Linda Elsegood: And were you offered any medication when you had this relapse?

Annie: Um, yes, I, I think I was taking steroids at the time, some kind of steroids. Um, I can't remember what it was called.

Linda Elsegood: And how bad was your MS? 

Annie: Um, well, compared to others, not that bad, but, um, I had no feeling from my waist downwards on the left-hand side. And so when I sat there, and I couldn't feel that I was sitting down, I amused my friend one day. I went to her house, I sat down on the chair as I thought, and I actually ended up on the floor, and she couldn't stop laughing because I couldn't feel the chair.

Um, but that kind of passed after some months, I think I just have the left side is a lot weaker than my right side. 

Linda Elsegood: So have you had any other symptoms, other those that you've just told us about? 

Annie: Right. Well, after I spoke to you a couple of weeks ago, I went into another relapse. I don't know if that's a word to use really.

So we haven't been great. Um, I told the doctor and he wanted me to take a ten-day course of steroids, which I did. Um. And I'm feeling much, much better now, but he did say to stop taking the LDN, so I did  and I started that up next week, I think the consequence of that relapse is that my left-hand motor skills are quite poor now.

I could still use it, but it's poorer than it was. But I'm still walking. 

Linda Elsegood: That's a big deal. So how did you hear about LDN? 

Annie: Um. I went to my doctor about something and I said, Oh, I am fed up. He said, why are you using that stick? Because I use a stick sometimes cause I'm a bit wobbly from time to time.

I said, well, I've got MS. He said, don't give me that. He said Google LDN and then come back and if you want to use it. And so I Googled it and I was quite impressed by what I read, so I thought I'll take this stuff. And so I've been taking it ever since.

So, um, I suppose it must be between six and nine months, at least. Maybe a year. I've been taking it for.

Linda Elsegood: Oh, you've got a very good GP. 

Annie: Yes, he is. He's great. 

Linda Elsegood: Also these days though, you can actually take LDN and steroids at the same time. So you need to be afraid of restarting, 

Annie: right? Yeah. Oh, that's interesting because it does say you shouldn't stop taking it, and I was a bit concerned that I would be doing damage anyway.

I seem to be okay, but as I say, I'm going to stop. 

Linda Elsegood: Your motor skills come back and lots of people have told me how it has helped relapses whilst taking LDN. They find that the relapses are not as severe, they don't last as long and they recover more or less fully from the attack.

So that would be interesting to see if that is the case with you.

Annie: Yeah.

Linda Elsegood: What would you say to other people who are contemplating 

trying LDN?

Annie: My view is you've got absolutely nothing to you, nothing to lose and I don't know if it's doing me any good. Psychologically, it's helped me tremendously. There must be something good in it for sure because I push myself to the limits and it is allowing me to push myself to the limits, you know?

So I would encourage anybody to try it, just try it and see if it doesn't suit them, that's fine. But I haven't had any adverse effects, you know, I'm just very happy to take it.

Linda Elsegood: Did you have any introductory side effects when you first started?

Annie: yes. I had a tremendous headache. Um, I'm prone to migraine anyway, and I think apparently that's part of the ms thing. I had a bad headache for several, several days, nearly a week actually and then it went, and I've been okay ever since. I still get the monthly migraine, but yes. Yeah. Um, I, I spoke to consultants about it, and they said it's something to do with the MS. People with MS can get migraines. We could also get rather depressed but I'm never depressed. Thank God.

Linda Elsegood: Is there anything else you'd like to add?

Annie: Mmm, I do think so. It's just that I don't know if the LDL is doing anything, but I think it must be because I've had this now for a very long time—this condition. And you know, as I said, I'm 62, and I'm doing really, really well. I had to do a bit of walking this morning, which I wasn't expecting. I had to put my car into the garage, and it had to stay there. So I had to go and get a bus to come home and walk from the bus stop. And I was able to do it with one stick, but I don't think I would have done that a year ago. So I'm thinking the LDN is helping somehow. 

Linda Elsegood: Very good. Well, thank you very much for sharing your story with us.

Any questions or comments you may have, please Contact Us.  I look forward to hearing from you. Thank you for joining us today. We really appreciated your company. Until next time, stay safe and keep well.

Anne-Maree - Australia: Hailey-Hailey Disease (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Anne-Marie from Australia who is 47 at the moment has suffered from Hailey-Hailey disease since her twenties. It was always misdiagnosed as eczema until about three and a half years ago after a biopsy revealed the true cause. It began with outbreaks under the armpit which would then develop a bacterial infection. The severity of these outbreaks has increased with age.

The recurrent infections were always treated with antibiotics. Her GP began investigations and a biopsy was taken and a correct diagnosis made. 

Following a hospital admission a year ago when her condition had worsened and she was being treated intravenously Anne-Marie did some research and discovered LDN and a Facebook worldwide support group of Hailey-Hailey disease sufferers.

Within two days of taking low dose Naltrexone prescribed by her forward-thinking GP, she noticed a distinct improvement with no introductory side effects. She began with only 0.5ml and gradually increased the dosage. The outbreaks dried up quite rapidly which was significant as the main problem with this disease is the risk of secondary infections. As a result of prolonged use of steroid creams causing thinning of the skin, she is susceptible to these. A mere scratch can trigger a Hailey-Hailey outbreak.

Instead of antibiotics, she is now able to treat the infections naturally with tea-tree, lavender and vinegar. 

Living on the coast she is now, thanks to LDN, able to go to the beach, take her children swimming and do volunteer surf lifesaver work.

She recommends it to all fellow sufferers.

This is just a summary. To hear the full interview click on the link.

Zora - Trinidad: Multiple Sclerosis (MS) (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Zora from Trinidad shares her Multiple Sclerosis (MS) and Low Dose Naltrexone (LDN) story on the LDN Radio Show with Linda Elsegood.

Zora first noticed her Multiple Sclerosis (MS) symptoms after the birth of her last daughter in 1980. The symptoms included excruciating back pains, fatigue and muscle pain. After her doctor said the problems were not gynaecological, Zora did some research and was diagnosed after four months.

She said “After I began taking Low Dose Naltrexone (LDN), my health began to soar. LDN has resolved my back pain and fatigue, I can exercise and interact socially again which is life changing.

To anyone considering LDN, you must try it. You’ve nothing to lose, the side effects are very minimal, if you have any at all.”

This is a summary of Zora’s interview. Please listen to the rest of Zora’s Multiple Sclerosis (MS) story by clicking on the video above.

Zoe - England: Chronic Fatigue Syndrome (CFS/ME) (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Linda Elsegood: I'd like to introduce Zoe from England who has multiple sclerosis. Welcome, Zoe.

Zoe: Hello.

Linda Elsegood: Could you tell me when you first started to notice symptoms? Uh, yes, it was, um, back in 1993, um, I started getting numbness in my toes. Um, but I wasn't diagnosed until 2001. Okay. And how old were you then?

Zoe: I was 51 at that time, I was a very active person. Um, certainly when I first started getting symptoms, I used to compete successfully in orienteering triathlons. Um, my children were still at secondary school and, um, I was working part-time. 

Linda Elsegood: So. At the time you were diagnosed, what were your symptoms 

Zoe: Well, I, uh, I had optic neuritis and, um, for a long time I'd had had problems with, um, foot drop then I was getting problems in my leg.

I hadn't connected the two, but of course, when I saw a new neurologist, he realized and, um, and so I got the diagnosis. 

Linda Elsegood: And how's the impact on your life being diagnosed with ms?

Zoe: Well, obviously I had, I had to stop stopped running my sporting activities. It just went downhill. I mean, I couldn't read a map, and I couldn't run so orienteering wasn't possible and it was just, um, really devastating to be told you have an incurable disease, which is only going to get progressively worse. So. You tend to go into deep despair, but I did have a very supportive family, and they just gave me enough space to come to terms with it. Um, which I suppose I did in my own way.

Um, I could still run a bit then, but it just became gradually worse over the years. I didn't have any very serious symptoms the optic neuritis went. Um, it was just gradually getting worse. 

Linda Elsegood: And how did you hear about LDN? 

Zoe: Well, I read that in youth pathways, and I also joined the MS group and some people in that group were taking it. Um, I think that was around about 2004 when I first heard about it. 

Linda Elsegood: When did you first start taking it again? 

Zoe: I didn't start taking it until, uh, 2010. I had tried before then I had no luck getting LDN when I first wanted it, which was, um, 2005. I got a load of information from new pathways. I sent it to my new role is and to my GP.

And when I discussed it with him, he just dismissed it. He said, Oh, that's just a placebo. You might just as well take all paper paste. 

Zoe: So I said to him, well, what do you recommend? What can you do for me? He said, there's nothing I can do for you. He didn't have any alternative. I've never seen him since, so I asked my GP if she would prescribe it, but she said, Oh no, I can't go against what the neurologist said. So, uh, that was it really, um, I believe I could have got a prescription from the States or something, but I don't know. I just didn't go down that road. Um, I tried lots of other remedies and, you know, with diets and various things, I tried antibiotics. Um, they all helped to some extent, and I think that was the placebo effect, but then eventually my MS nurse said, what don't you see this neurologist, another man. And he said there was no harm in trying the LDN though he didn't encourage it. And by luck, my GP was having a baby and her replacement said you can try this, good idea. So I eventually started it in December last year. 

Linda Elsegood:  Did you notice any initial side effects? 

Zoe: Yes. Um, I did. I, uh, I got a headache which lasted about a week. I felt very dizzy at first. The first day I felt dizzy and I didn't dare drive a car. Um, the headache you lasted about a week and then went off but I also felt very sleepy. Um, when I increased the dose, I could get the unpleasant dreams, which was, is sort of usual side effects, I believe. 

Linda Elsegood: And how long did it take before you found that LDN was a benefit?

Zoe: Um, well it started being beneficial more or less about the first three weeks, I suppose. 

Linda Elsegood:  what benefits have you noticed being on LDN? 

Zoe: Well, my energy increased. I was up to do more. Uh, I don't get so tired and what I really noticed after a couple of months, Was that my concentration had really improved.

Um, I could think about things without getting muddled. Um, like I used to, uh, I did a tax calculation, which I'd been putting off for months and, um, I found I could go out in the evenings and do things like that. Okay. I kept doing things I hadn't done before, not all at once. I mean, you know, and another day I watched the car, and I kept thinking, I haven't done that for a long time.

Linda Elsegood:  if you were to score your quality of life on a rating of one to 10, 10 being the highest before you started LDN, what would it have been? 

Zoe: Oh, four. I should think. 

Linda Elsegood: What would you say to other people who are contemplating trying LDN

Zoe: I think they should go for it. Um, yeah. Start as soon as you can. I mean, if you can get. If you can get it you might need to persevere to get through the initial discomfort.

I would say the starting dose seems to be quite critical. I got it in a liquid form, and it was easy to adjust. So although I started at three milligrams, I reduced it quite soon to two milligrams and I found that I could cope with that better. So that's probably by some of those headaches and tiredness went. it's, it's quite an easy thing to do, and you just need to persevere. 

Linda Elsegood: Well, thank you very much for sharing the story with us. 

Any questions or comments you may have, please Contact Us.  I look forward to hearing from you. Thank you for joining us today. We really appreciated your company. Until next time, stay safe and keep well.

Yvonne - US: Fibromyalgia, Multiple Sclerosis (MS) (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Yvonne from the United States takes low dose naltrexone (LDN) for multiple sclerosis and fibromyalgia. She had lifelong tremors, later developed dizziness/vertigo and frequent bladder infections, and finally eye problems.  All before age 20. She rated her quality of life as 3 to 4.

A friend of MySpace told her about LDN, and started taking it in October 2010, and feels her quality of life has gone up to 7 to 8. She no longer needs pain pills often.

She definitely recommends LDN for how it has improved her quality of life.

Listen to the video for the full story.

Any questions or comments you may have, please contact us at contact@ldnresearchtrust.org. I look forward to hearing from you. Thank you for joining us today. 

Wilma - Netherlands: Hashimoto's Thyroiditis, Hypothyroidism (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Wilma from the Netherlands shares her Hashimoto’s and Low Dose Naltrexone (LDN) story on the LDN Radio Show with Linda Elsegood.

Wilma first noticed problems with her thyroid in 2011 and was swiftly diagnosed within a year with Hashimoto’s, which had a big impact on her life. Wilma could no longer walk, and things worsened when her appendix broke.

Around 2014, Wilma discovered Low Dose Naltrexone (LDN) and has not looked back at any treatment since. 

She said “It’s completely changed my life. I was probably operating about 30% beforehand. I felt better within six weeks of starting LDN. My life’s gone from 3/10 to 9/10.

Don’t be afraid to try LDN, especially if your own GP won't prescribe it to you. Be persistent and try somewhere else, because the benefits are there to be seen.”

This is a summary of Wilma’s interview. Please listen to the rest of Wilma’s Hashimoto’s story by clicking on the video above.

Wendy - Wales: Psoriasis (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Wendy from Wales takes Low Dose Naltrexone (LDN) for Psoriasis. She first started noticing symptoms twelve years ago. She found lots of dry patches on her elbows and knees so was prescribed a steroid cream. However she felt it was not working, as after she stopped using the cream it was worse and had spread to other parts of the body. Wendy states that around two and a half years ago is when the Psoriasis peaked, as it had spread all over her whole body.

Wendy has been taking Low Dose Naltrexone (LDN) for approximately two years now. She felt no introductory side effects, and after months of taking the medication she has noticed improvements in her skin such as a more natural colour and texture, less itchiness, cracking and the skin has regenerated. 

This is a summary, to hear the whole interview click the video link.

Wendy - England: Multiple Sclerosis (MS) (LDN, low dose naltrexone) from LDN Research Trust on Vimeo.

Wendy was diagnosed with Multiple Sclerosis in 2000 at the age of 60. She first heard about Low Dose Naltrexone on an online forum and her doctor refused to prescribe it so she got a prescription privately. 

On starting LDN Wendy had a little sleep disturbance to begin with and that settled down within 3 weeks, other than that no other side effects but she did start to feel better within a month. Although LDN hasn’t fixed everything for her her quality of life has improved and she says she would happily recommend Low Dose Naltrexone to other MS sufferers. Her friends with MS are sadly afraid to try LDN which is a great shame. 

For more video interviews with patients and medical professionals please visit https://ldnresearchtrust.org/ldn-videos