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Low-Dose Naltrexone in Diseases' Treatment: Global Review
Research Inventy: International Journal of Engineering And Science
February 2016
https://www.researchgate.net/profile/Paula_Soares14/publication/307906476_Low-Dose_Naltrexone_in_Diseases'_Treatment_Global_Review/links/57d14a1808ae6399a38b3fea/Low-Dose-Naltrexone-in-Diseases-Treatment-Global-Review.pdf
Naltrexone is a non-selective opioid antagonist, which shows effects on delta, mu and kappa receptors. Its therapeutic use is designed for drug addicts’ treatment, reducing withdrawal side effects. However, several researchers have used low-dose Naltrexone (LDN) for therapeutic purposes in diseases associated to immune system deficiency and inflammatory and tumor processes. Consequently, enhance
evidences that LDN use hypothesis promotes, through a compensation mechanism, an increase of endorphins and enkephalins, in addition to opioid receptors up-regulation mechanism, in Central Nervous System (CNS), becoming it a potentially effective clinical practice in these pathologies. Thus, we present a review about LDN use in different pathologies, all they published in literature, and its therapeutic effects, enabling us to conclude that 3.0-4.5mg/day dose use in humans is effective for idiopathic diseases with alterations in immune system, as well as those ones with inflammatory and tumor characteristics.
Keywords – Diseases, Low dose Naltrexone, Treatment.