Low Dose Naltrexone (LDN) and dry eyes

Low Dose Naltrexone (LDN) and dry eyes.

A March 2019 case study was published in the medical literature discussing the successful treatment of dry eyes associated with Sjorgen's syndrome (SS). This was taken orally. LDN can be delivered orally as well as transdermally (topically) ,and in theory, compounded in an ophthalmic sterile solution. There are sterile compounding pharmacies that can produce a LDN eye drop formulation. Oral and TD dose goals are 4.5mg/day. In 2020 another EBM publication reported two additional patients with SS having relief with LDN therapy. There are precedent cases of use of ophthalmic solutions and while I personally have not used it in my practice, I would be inclined to do so if the need arises.

Yusuf M Saleeby, MD
LDN Specialist and Advisor to the LDN Research Trust